DRSC/TRiP Functional Genomics Resources

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Protein Alignment SDK2 and dpr3

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001014459.2 Gene:dpr3 / 3346208 FlyBaseID:FBgn0053516 Length:522 Species:Drosophila melanogaster


Alignment Length:352 Identity:76/352 - (21%)
Similarity:127/352 - (36%) Gaps:125/352 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   177 DAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANA 241
            ||.|....|.::::.|..|||  :|.:.:.|            .|:|.:...|.:|..::|..::
  Fly   213 DAKRERSGAADEESQDADTSQ--SLPIFDFG------------MPRNITGRTGHTEAIIKCRVDS 263

Human   242 RPLIKLH---IIW--KKDGVLLSGG----ISDHNRRLT-----------IPNPTGSDAGYYECEA 286
                 ||   :.|  |:|..:|:.|    .||...::|           :..|...|:|.|||:.
  Fly   264 -----LHDKSVSWIRKRDLHILTVGTATYTSDKRFQVTESKDSREWTLHVKAPLAKDSGIYECQV 323

Human   287 VLRSSSVPSVVRGAYLSVLEPPQFVK-----EPERHITAEMEKVVDIPCQ---AKGVPPPSITWY 343
                ::.|.:.....|:::|.....|     .|:.|..|....:::...|   .|.:.|  |.||
  Fly   324 ----NTEPKMSMAFQLNIIEISPDAKAVISGPPDLHFKAGSAIILNCLVQQPSVKDIGP--IYWY 382

Human   344 KDAAVVEVEKLTRFRQRNDGGLQI--------SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI 400
            :...::     |.| ..:||..:|        .| :|:||                         
  Fly   383 RGEHMI-----TPF-DADDGQPEIPAGRGEHPQG-IPEDT------------------------- 415

Human   401 APNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT 465
            :||           |.||.| ..:...|.|.|:..|.|:.:               ...|.||..
  Fly   416 SPN-----------DIMSEV-DLQMEFATRIAMESQLGDTL---------------KSRLRISNA 453

Human   466 HISDAGTYTCLATNSRGVDEASADLVV 492
            ..:|.|.|||..|.:     :||.::|
  Fly   454 QTTDTGNYTCQPTTA-----SSASVLV 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352 9/25 (36%)
Ig 132..210 CDD:299845 10/32 (31%)
IG_like 222..304 CDD:214653 22/101 (22%)
IGc2 233..286 CDD:197706 17/72 (24%)
I-set 308..397 CDD:254352 19/104 (18%)
Ig 326..394 CDD:143165 15/78 (19%)
I-set 402..492 CDD:254352 22/89 (25%)
Ig 416..492 CDD:299845 19/75 (25%)
Ig 502..586 CDD:299845
IG_like 502..586 CDD:214653
FN3 590..681 CDD:238020
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
dpr3NP_001014459.2 Ig 243..330 CDD:299845 22/95 (23%)
IG_like 243..329 CDD:214653 22/94 (23%)
Ig 350..464 CDD:299845 36/174 (21%)
IG_like <441..477 CDD:214653 13/55 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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