| Sequence 1: | NP_001138424.1 | Gene: | SDK2 / 54549 | HGNCID: | 19308 | Length: | 2172 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001097440.1 | Gene: | Unc-89 / 3346201 | FlyBaseID: | FBgn0053519 | Length: | 4218 | Species: | Drosophila melanogaster |
| Alignment Length: | 1971 | Identity: | 376/1971 - (19%) |
|---|---|---|---|
| Similarity: | 659/1971 - (33%) | Gaps: | 580/1971 - (29%) |
- Green bases have known domain annotations that are detailed below.
|
Human 7 WTLLALHQIRAAR-----AQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPL-EFKWLHNNR 65
Human 66 EL-----TKFSLE----YRYMITSLDRTHAGFYRCIVRNRMG------ALLQRQTEVQVAYMGSF 115
Human 116 EEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRI-AITLENTLV--ILSTVAP- 176
Human 177 DAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKN-----------TSVVAGT 230
Human 231 SEVTLECVANARPLIKLHIIWKKDGVLLSGGIS--------DHNRRLTIPNPTGSDAGYYECEAV 287
Human 288 LRSSSVPSVVRGAYLSVL---------EPPQFVKEPERHITAE--MEKVVDIPCQAKGVPPPSIT 341
Human 342 WYKDAAVVEVEKLTRFRQRNDG---GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI--A 401
Human 402 PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS---LLIS 463
Human 464 PTHISDAGTYTCLATNSRGVD--EASADLV--VWARTRITKPP------QDQSVIKGTQASMVCG 518
Human 519 VTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLH--ISQTWSGDIGTYTCRVISAGGNDSRS 581
Human 582 AHLRVRQL-----------------------PHAPEHPVATLSTVERRAINLTW--TKPFDGNSP 621
Human 622 LIRYILEMSE-NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE--RV 683
Human 684 SLPEEPPTA--------------------------PPQNVIA----------------------- 699
Human 700 -----------------------SGRTNQSIM----------------IQWQPPPESHQNGILKG 725
Human 726 YI--------------------------IRYCLAGLPVG--YQFKN---ITDADVNNLLLEDLII 759
Human 760 WTNYEIEVAAYNS--AGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFING 822
Human 823 INQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDG------- 880
Human 881 --PRSTP------QLVRT--HEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEY 935
Human 936 NRTNTRVTHYLPNVT--LEY---RVTGLTALTTYTIEVAAM-----------TSKGQGQVSASTI 984
Human 985 SSGVP----PE-----------------------LPGPPTNLGISNIGPRSVTLQFRPGY----- 1017
Human 1018 --------DGKTSISRWLV---EAQVGV-VGEGEEWLLI---------HQLSNEPDARSMEVPD- 1060
Human 1061 -----LNPFTCYSFRMRQVNIVGTSPPSQ--PSRKIQTLQAPPDMAP-ANVSLRTASETSLWLRW 1117
Human 1118 MPLPEME---------YNGNPES-------VGYKIK---YSRSDGHGKTLSHVVQDRVE------ 1157
Human 1158 ---------RDYTIEDLEEWTEYRVQVQAFNAIGS--------GP------WSQTVVGRTRESVP 1199
Human 1200 -------------SSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYK---EKDSDTQP 1248
Human 1249 RFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVR 1313
Human 1314 T---TSVRLIW-QPPAAPNGIILAYQITHRLN-----TTTANTATVEVLAPSARQYTATGLKPES 1369
Human 1370 VYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRY 1434
Human 1435 YTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA 1499
Human 1500 APDEAPTIL-SVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGF--TLRGINNPG 1561
Human 1562 ATW-------AELTSMYSMRN 1575 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| SDK2 | NP_001138424.1 | Ig | 27..109 | CDD:299845 | 25/97 (26%) |
| IG_like | 40..109 | CDD:214653 | 23/84 (27%) | ||
| I-set | 120..203 | CDD:254352 | 23/86 (27%) | ||
| Ig | 132..210 | CDD:299845 | 22/81 (27%) | ||
| IG_like | 222..304 | CDD:214653 | 18/100 (18%) | ||
| IGc2 | 233..286 | CDD:197706 | 13/60 (22%) | ||
| I-set | 308..397 | CDD:254352 | 26/93 (28%) | ||
| Ig | 326..394 | CDD:143165 | 18/70 (26%) | ||
| I-set | 402..492 | CDD:254352 | 21/96 (22%) | ||
| Ig | 416..492 | CDD:299845 | 18/82 (22%) | ||
| Ig | 502..586 | CDD:299845 | 23/91 (25%) | ||
| IG_like | 502..586 | CDD:214653 | 23/91 (25%) | ||
| FN3 | 590..681 | CDD:238020 | 25/93 (27%) | ||
| FN3 | 693..786 | CDD:238020 | 21/187 (11%) | ||
| FN3 | 794..890 | CDD:238020 | 19/110 (17%) | ||
| FN3 | 895..983 | CDD:238020 | 16/103 (16%) | ||
| FN3 | 993..1087 | CDD:238020 | 25/127 (20%) | ||
| FN3 | 1099..1194 | CDD:238020 | 24/143 (17%) | ||
| FN3 | 1201..1290 | CDD:238020 | 17/91 (19%) | ||
| FN3 | 1301..1394 | CDD:238020 | 25/101 (25%) | ||
| FN3 | 1400..1484 | CDD:238020 | 6/83 (7%) | ||
| FN3 | 1503..1616 | CDD:238020 | 15/83 (18%) | ||
| FN3 | 1626..1719 | CDD:238020 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1707..1729 | ||||
| FN3 | 1724..1805 | CDD:238020 | |||
| FN3 | 1837..1916 | CDD:238020 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2039..2067 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2098..2172 | ||||
| PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 | 2166..2172 | ||||
| Unc-89 | NP_001097440.1 | RhoGEF | 90..260 | CDD:238091 | |
| PH_unc89 | 275..388 | CDD:270134 | |||
| Atrophin-1 | <493..690 | CDD:331285 | |||
| TonB_N | 502..>596 | CDD:318287 | |||
| I-set | 1017..1108 | CDD:333254 | |||
| I-set | 1123..1212 | CDD:254352 | |||
| I-set | <1236..1299 | CDD:333254 | |||
| I-set | 1313..1403 | CDD:254352 | |||
| Ig_3 | 1406..1487 | CDD:316449 | |||
| I-set | 1499..1595 | CDD:254352 | |||
| I-set | 1599..1690 | CDD:333254 | |||
| I-set | 1694..1786 | CDD:254352 | |||
| I-set | <1836..1903 | CDD:333254 | |||
| I-set | 1922..2005 | CDD:333254 | |||
| I-set | 2018..2108 | CDD:333254 | |||
| I-set | 2113..2214 | CDD:333254 | 3/17 (18%) | ||
| I-set | 2220..2302 | CDD:254352 | 23/82 (28%) | ||
| I-set | 2318..2408 | CDD:254352 | 26/112 (23%) | ||
| I-set | 2415..2506 | CDD:254352 | 18/97 (19%) | ||
| I-set | 2519..2608 | CDD:254352 | 26/93 (28%) | ||
| I-set | 2615..2696 | CDD:254352 | 18/84 (21%) | ||
| I-set | 2717..2805 | CDD:254352 | 22/89 (25%) | ||
| FN3 | 2834..2925 | CDD:238020 | 26/95 (27%) | ||
| I-set | <2996..3063 | CDD:333254 | 6/66 (9%) | ||
| I-set | 3067..3157 | CDD:333254 | 16/107 (15%) | ||
| PK_Unc-89_rpt1 | 3182..3440 | CDD:271011 | 50/269 (19%) | ||
| I-set | 3654..3744 | CDD:333254 | 18/109 (17%) | ||
| FN3 | 3748..3840 | CDD:238020 | 26/104 (25%) | ||
| STKc_Unc-89_rpt2 | 3893..4151 | CDD:271014 | 17/99 (17%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.910 | |||||