DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and dpr4

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001014616.2 Gene:dpr4 / 3346160 FlyBaseID:FBgn0053512 Length:323 Species:Drosophila melanogaster


Alignment Length:275 Identity:63/275 - (22%)
Similarity:106/275 - (38%) Gaps:69/275 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   308 PQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWY--KDAAVVEVEKLT-----RFRQRNDGG- 364
            |.|.....|.:||.:.:...:.|:.:.:...:::|.  :|..::.|..||     ||:..:..| 
  Fly    45 PYFDNSSRREVTATVGQAALLHCRVRNLGDRAVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGS 109

Human   365 ----LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI----------- 414
                |:||...|.|:|.::|         |.||       .|.|::|...:.|:           
  Fly   110 DEWTLRISSPQPRDSGTYEC---------QVST-------EPKISQGFRLNVVVSRAKILGNAEL 158

Human   415 ---DGMSVVLACETSGAPRPA--ITWQKGERIL---ASGSVQLPRFTPLESGSLLISPTHISDAG 471
               .|..:.|.|....:|.|.  |.|.||:|::   ..|.:.:.......:..|||:....:|:|
  Fly   159 FIKSGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQRGGINVITERSTRTSKLLIAKATPADSG 223

Human   472 TYTCLATNSRGVDEASADLVVW--------------ARTRITKPPQDQSV--IKGTQASM-VCGV 519
            .|||..::|     .||.:||.              :.....:|....||  :..|..|| |..|
  Fly   224 NYTCSPSSS-----DSASVVVHVINGEHPAAMQHGNSSATCLRPLSSTSVPFVLATWMSMTVASV 283

Human   520 THDPRVTIRYIWEKD 534
            ..:..:.|.:.|..|
  Fly   284 AWNSNLNINWNWSPD 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845
IG_like 40..109 CDD:214653
I-set 120..203 CDD:254352
Ig 132..210 CDD:299845
IG_like 222..304 CDD:214653
IGc2 233..286 CDD:197706
I-set 308..397 CDD:254352 24/100 (24%)
Ig 326..394 CDD:143165 18/79 (23%)
I-set 402..492 CDD:254352 26/108 (24%)
Ig 416..492 CDD:299845 22/80 (28%)
Ig 502..586 CDD:299845 10/36 (28%)
IG_like 502..586 CDD:214653 10/36 (28%)
FN3 590..681 CDD:238020
FN3 693..786 CDD:238020
FN3 794..890 CDD:238020
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
dpr4NP_001014616.2 V-set 53..146 CDD:284989 25/108 (23%)
IG_like 53..145 CDD:214653 25/107 (23%)
ig 153..227 CDD:278476 17/73 (23%)
IG_like 161..>227 CDD:214653 17/65 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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