DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SDK2 and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	104/450 - (23%)
Similarity:	160/450 - (35%)	Gaps:	115/450 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   199 ITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGIS 263
            |.|||.|.........|..:||.:|.::..| .:.|..||.|           ...|..:||.
  Fly    82 IDLTVSNKISSVGAFEPDFVIPLENVTIAQG-RDATFTCVVN-----------NLGGHRVSGD-- 132

Human   264 DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDI 328
                                      .||.|:.|           .::|...:.|.|..|.|
  Fly   133 --------------------------GSSAPAKV-----------AWIKADAKAILAIHEHV--- 157

Human   329 PCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG---LQISGLVPDDTGMFQCFARNAAGEVQ 390
                               :...::|:  .|.||..   |.|.|:..:|.|.:.|.......::|
  Fly   158 -------------------ITNNDRLS--VQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQ 201

Human   391 TSTYLAVTSIAPNI----TRGPLDSTVIDGMSVVLACETSGAPRPAITWQK--GERILA-SGSVQ 448
            |:|...|  |.|:|    |.|  |..|.:|.|..|.|...|.|:|.|||::  |..|:| :||.|
  Fly   202 TATLEVV--IPPDIINEETSG--DMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIARNGSHQ 262

Human   449 LPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA---DLVVWARTRITKPPQDQSVIKG 510
            ..:...:|...|.:|....|:.|.|.|:|:|  ||....:   .|.|.....:..|.|.......
  Fly   263 KTKAQSVEGEMLTLSKITRSEMGAYMCIASN--GVPPTVSKRMKLQVHFHPLVQVPNQLVGAPVL 325

Human   511 TQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGS-------LHISQTWSGDIGTYT 568
            |..:::|.|...|: .|.| |:::...:..........::..:       |||.:..|.|.|.|.
  Fly   326 TDVTLICNVEASPK-AINY-WQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGYK 388

Human   569 CRVISAGGNDSRSAHLRVRQLPHAPEHPVA------TLSTVERRAINLTWTKPFDGNSPL 622
            |  ||..........:|:.::    |.|..      .|:.|.:..:....|:..||:..|
  Fly   389 C--ISKNSIGDTEGTIRLYEM----ERPGKKILRDDDLNEVSKNEVVQKDTRSEDGSRNL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352	2/3 (67%)
		Ig	132..210	CDD:299845	5/10 (50%)
		IG_like	222..304	CDD:214653	13/81 (16%)
		IGc2	233..286	CDD:197706	7/52 (13%)
		I-set	308..397	CDD:254352	18/91 (20%)
		Ig	326..394	CDD:143165	12/70 (17%)
		I-set	402..492	CDD:254352	34/99 (34%)
		Ig	416..492	CDD:299845	28/81 (35%)
		Ig	502..586	CDD:299845	18/90 (20%)
		IG_like	502..586	CDD:214653	18/90 (20%)
		FN3	590..681	CDD:238020	7/38 (18%)
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	35/187 (19%)
		ig	102..195	CDD:278476	30/167 (18%)
		IG_like	219..307	CDD:214653	31/91 (34%)
		Ig	221..307	CDD:299845	30/87 (34%)
		Ig	311..404	CDD:299845	19/96 (20%)
		IG_like	327..405	CDD:214653	17/81 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810