DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK2 and Fas2

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001284854.1	Gene:	Fas2 / 31364	FlyBaseID:	FBgn0000635	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	218/992 - (21%)
Similarity:	340/992 - (34%)	Gaps:	282/992 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    15 IRAARAQDDV-SPYFKTEPVRTQVHLEGNRLVLTC---MAEGSWPLEFKWL--HNNRELTK---- 69
            |...|||..: ..|.|.|..|..|   |..|:|||   :.|.|...:.:|.  .||..|.|
  Fly    23 IELTRAQSPILEIYPKQEVQRKPV---GKPLILTCRPTVPEPSLVADLQWKDNRNNTILPKPNGR 84

Human    70 ------------FSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQ 122
                        .||  ..|||||.....|.|.|........:|::...::.....::....::|
  Fly    85 NQPPMYTETLPGESL--ALMITSLSVEMGGKYYCTASYANTEILEKGVTIKTYVAITWTNAPENQ 147

Human   123 SVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVN 187
            ..:.|:..|:.. .:.:.|.|.:.|.|:|..|..::...:...|.|:|.:....|.|.|..:|..
  Fly   148 YPTLGQDYVVMC-EVKADPNPTIDWLRNGDPIRTTNDKYVVQTNGLLIRNVQESDEGIYTCRAAV 211

Human   188 DKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWK 252
            .:.|:....   |:.||..      |.|.||..|.|...|.| ......|.|..:|:.:  |.|.
  Fly   212 IETGELLER---TIRVEVF------IQPEIISLPTNLEAVEG-KPFAANCTARGKPVPE--ISWI 264

Human   253 KDGVLLSGGISD------HNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV 311
            :|...|:...:|      ....:||.:.:..|.|.|.|.|..|:..|....:   |:||..||..
  Fly   265 RDATQLNVATADRFQVNPQTGLVTISSVSQDDYGTYTCLAKNRAGVVDQKTK---LNVLVRPQIY 326

Human   312 KEPERHITAEMEKVVDIPCQAKGVPPPSITWYK--------------DAAVVEVEKLTRFRQRND 362
            :  ..::|....|.:.|.|:|||.|.|:||:.:              |..::........|..:.
  Fly   327 E--LYNVTGARTKEIAITCRAKGRPAPAITFRRWGTQEEYTNGQQDDDPRIILEPNFDEERGEST 389

Human   363 GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITR----GPLDSTVIDGMSVVLAC 423
            |.|:||.....|.|::||.|||...:...:.::.| ..||:.:.    .|:.|.  :.....|:|
  Fly   390 GTLRISNAERSDDGLYQCIARNKGADAYKTGHITV-EFAPDFSHMKELPPVFSW--EQRKANLSC 451

Human   424 ETSGAPRPAITWQKGER-----------ILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
            ...|.|...|.|....|           |:.:|    ||      ..|::.|........|.|:|
  Fly   452 LAMGIPNATIEWHWNGRKIKDLYDTNLKIVGTG----PR------SDLIVHPVTRQYYSGYKCIA 506

Human   478 TNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTES 542
            ||..|..|....|      :..:.|...|..|.:|.:                     ||..|
  Fly   507 TNIHGTAEHDMQL------KEARVPDFVSEAKPSQLT---------------------ATTMT-- 542

Human   543 HPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRA 607
                 .|..|.       |.::|.                             |:...|...:.|
  Fly   543 -----FDIRGP-------STELGL-----------------------------PILAYSVQYKEA 566

Human   608 INLTWTKPFDGN-SPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDV 671
            :|..|:..::.: ||...||:|                         ||.|...|.||..|.|.|
  Fly   567 LNPDWSTAYNRSWSPDSPYIVE-------------------------GLRPQTEYSFRFAARNQV 606

Human   672 GKGQF----SKDTERVSLPEEPPTAPPQNVIASGRTNQSIM--------IQWQPPPESHQNGILK 724
            |.|.:    .:.|.|.|.||||  .|..|.:...:....::        ::|..|.::.:.  :.
  Fly   607 GLGNWGVNQQQSTPRRSAPEEP--KPLHNPVQHDKEEPVVVSPYSDHFELRWGVPADNGEP--ID 667

Human   725 GYIIRYCLAGLPVGYQFKNITDA-------DVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKV 782
            .|.|:|| .|:.:...:..:.::       :..:..:..|:..|.|.||:.|:|:.|   |||
  Fly   668 RYQIKYC-PGVKISGTWTELENSCNTVEVMETTSFEMTQLVGNTYYRIELKAHNAIG---YSS-- 726

Human   783 TEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARP 847
                        |.::..:.|                 .||               :|..|..|.
  Fly   727 ------------PASIIMKTT-----------------RGI---------------DVIQVAERQ 747

Human   848 NFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLK 912
            .|..:..||...|......:...:||..|...|..:|  :.|..:..|        |||.|.:
  Fly   748 VFSSAAIVGIAIGGVLLLLFVVDLLCCITVHMGVMAT--MCRKAKRSP--------SEIDDEA-- 800

Human   913 VSWQEPGEKNGILTGYR 929
                    |.|.|.|:|
  Fly   801 --------KLGSLYGWR 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845	28/102 (27%)
		IG_like	40..109	CDD:214653	23/89 (26%)
		I-set	120..203	CDD:254352	18/82 (22%)
		Ig	132..210	CDD:299845	17/77 (22%)
		IG_like	222..304	CDD:214653	21/87 (24%)
		IGc2	233..286	CDD:197706	14/58 (24%)
		I-set	308..397	CDD:254352	26/102 (25%)
		Ig	326..394	CDD:143165	22/81 (27%)
		I-set	402..492	CDD:254352	24/104 (23%)
		Ig	416..492	CDD:299845	21/86 (24%)
		Ig	502..586	CDD:299845	11/83 (13%)
		IG_like	502..586	CDD:214653	11/83 (13%)
		FN3	590..681	CDD:238020	21/95 (22%)
		FN3	693..786	CDD:238020	20/107 (19%)
		FN3	794..890	CDD:238020	16/95 (17%)
		FN3	895..983	CDD:238020	10/35 (29%)
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Fas2	NP_001284854.1	IG_like	39..133	CDD:214653	26/98 (27%)
		IG_like	144..226	CDD:214653	19/85 (22%)
		IGc2	152..209	CDD:197706	14/57 (25%)
		I-set	230..319	CDD:254352	25/94 (27%)
		IGc2	243..309	CDD:197706	17/68 (25%)
		IG_like	330..424	CDD:214653	24/93 (26%)
		IGc2	339..412	CDD:197706	21/72 (29%)
		Ig	447..518	CDD:143165	20/80 (25%)
		fn3	534..611	CDD:278470	29/165 (18%)
		FN3	640..735	CDD:238020	19/114 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810