DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SDK2 and DIP-alpha

DIOPT Version :9

Sequence 1:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens
Sequence 2:	NP_001259218.1	Gene:	DIP-alpha / 31322	FlyBaseID:	FBgn0052791	Length:	554	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	103/475 - (21%)
Similarity:	166/475 - (34%)	Gaps:	114/475 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   188 DKNGDNKTSQPITLTV---ENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHI 249
            |:||  |....:.|.|   |.:|.    ..|..:....|.||..| .:.|..|  :.|.|....:
  Fly    18 DRNG--KMLIHLLLIVSLLEAIGA----FQPEFVESISNVSVAVG-RDATFTC--HVRHLGGYRV 73

Human   250 IWKKDGV----LLSGGISDHNRRLTIPN------------PTGSDAGYYECEAVLRSSSVPSVVR 298
            .|.|...    .:...:..||.|:|:.:            .:..|.|.|.|:  |.:..:.|.:
  Fly    74 GWLKADTKAIQAIHENVITHNPRVTVSHLDQNTWNLHIKAVSEEDRGGYMCQ--LNTDPMKSQI- 135

Human   299 GAYLSVLEPPQFVKE-PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 362
             .:|.|:.||.|:.| ....:.......|.:.|:|:|.|.|.:||                :|.|
  Fly   136 -GFLDVVIPPDFISEDTSSDVIVPEGSSVRLTCRARGYPEPIVTW----------------RRED 183

Human   363 GG---------------------LQISGLVPDDTGMFQCFARN-----AAGEVQTSTYLAVTSIA 401
            |.                     |::|.:..::.|.:.|.|.|     .:..:..|.:.......
  Fly   184 GNEIVLKDNVGTKTLAPSFRGEVLKLSKISRNEMGSYLCIASNGVPPSVSKRISLSIHFHPVIQV 248

Human   402 PN-ITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK--GERILASGS--VQLPRFTPLESG-SL 460
            || :...||      |..|.:.|....:|:....|.|  ||.|:.||.  ||....:..|:. |:
  Fly   249 PNQLVGAPL------GTDVQIECHVEASPKSINYWIKDTGEMIVTSGKYHVQESSQSMYETKMSM 307

Human   461 LISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHD--- 522
            ::......|.|:|.|:|.||.|..::|..|.     .|..|.::::.:.|.......|.:.|
  Fly   308 IVRKFQKDDVGSYRCIAKNSLGEVDSSIRLY-----EIPGPNRNKNPLNGGGKGGGAGGSLDADA 367

Human   523 -------PRVTIRYIWEKDGATLGTESHPRIRLDRNGSL-----HISQTWSGDIGTYTCRVISAG 575
                   .:|.:.|..|.:....|:...........|.|     |:..|......|:      ..
  Fly   368 NDILKQKQQVKVTYQPEDEELQYGSVEDFEAEGGEGGGLTPLSPHVYYTSGNKPATH------KP 426

Human   576 GNDSRSAHLRVRQLPHAPEH 595
            ||...:.||. :|..|...|
  Fly   427 GNSGGNQHLH-QQHHHHHHH 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352	5/14 (36%)
		Ig	132..210	CDD:299845	8/24 (33%)
		IG_like	222..304	CDD:214653	21/97 (22%)
		IGc2	233..286	CDD:197706	14/68 (21%)
		I-set	308..397	CDD:254352	21/115 (18%)
		Ig	326..394	CDD:143165	18/93 (19%)
		I-set	402..492	CDD:254352	29/95 (31%)
		Ig	416..492	CDD:299845	25/80 (31%)
		Ig	502..586	CDD:299845	16/98 (16%)
		IG_like	502..586	CDD:214653	16/98 (16%)
		FN3	590..681	CDD:238020	2/6 (33%)
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
DIP-alpha	NP_001259218.1	IG_like	49..129	CDD:214653	19/84 (23%)
		Ig	51..131	CDD:299845	18/84 (21%)
		I-set	144..240	CDD:254352	20/111 (18%)
		IGc2	159..228	CDD:197706	17/84 (20%)
		Ig	244..337	CDD:299845	28/98 (29%)
		I-set	244..337	CDD:254352	28/98 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810