DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and kirre

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001245505.1 Gene:kirre / 31292 FlyBaseID:FBgn0028369 Length:956 Species:Drosophila melanogaster


Alignment Length:1028 Identity:203/1028 - (19%)
Similarity:312/1028 - (30%) Gaps:371/1028 - (36%)


- Green bases have known domain annotations that are detailed below.


Human    17 AARAQDDVSP--------YFKTEPVRTQVHLEGNRLVLTC-----MAEGSWPLEFKWLHNNRELT 68
            |:.|.|:..|        :|..|| :.|..:.|:|:.|.|     :....|..:...|..:|.|:
  Fly    65 ASSANDESKPKGGDNGGQHFAMEP-QDQTAVVGSRVTLPCRVMEKVGALQWTKDDFGLGQHRNLS 128

Human    69 KFSLEYRYMITSLDRTHAGF--------------YRCIV----------RNRMGALL-----QRQ 104
            .|.   ||.:...|. ...|              |:|.|          |:|...|.     :..
  Fly   129 GFE---RYSMVGSDE-EGDFSLDIYPLMLDDDAKYQCQVGPGPQGEQGIRSRFAKLTVLVPPEAP 189

Human   105 TEVQVAYMGSFEEGE-KHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGR-----------KIPPS 157
            ...|..|:.:.|:.| :.:.||.|           ..|..::||. ||.           |.|.:
  Fly   190 KITQGDYLVTTEDREIELECVSQG-----------GKPAAEITWI-DGLGNVLTKGIEYVKEPLA 242

Human   158 SRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPK 222
            ....||..:.|.:..........:..||   :|..::|.:...|.:|      ...||.:|:   
  Fly   243 DSRRITARSILKLAPKKEHHNTTFTCQA---QNTADRTYRSAKLLLE------VKYAPKVIV--- 295

Human   223 NTSVVAGT---------SEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGS- 277
              |||.|.         :||.|.|.|:|.| .:|...|..:..|::|   |...::.|.|.:.. 
  Fly   296 --SVVGGALAGGKIPEGAEVILSCQADANP-HELSYRWFINDELMTG---DFTTKMIIHNVSRQY 354

Human   278 -DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSIT 341
             || ..:||.|   ::|....:...|.:...|.|.:.|. .:.|::...|.:.|...|.|.|.|.
  Fly   355 HDA-IVKCEVV---NAVGKSEQSKKLDISFGPVFRQRPV-SVEADLGATVSMRCDVAGNPEPEIE 414

Human   342 WYKDAA--VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA-RNAAGEVQTSTYLAVTSIAPN 403
            |..:.:  ||.|....:        |::|.   :..|.:.|.| .|...|:.....|.|.. ||.
  Fly   415 WISENSDQVVGVAAELK--------LKVSS---ETAGRYFCKAVVNGFPEIGAEATLYVKR-API 467

Human   404 ITRGPLDSTVIDGMSVVLACETSGAPRPA-ITWQKGERILASGSV----------QLPRFTPLES 457
            ||...:....:.| .|.:.|.....|:.. |.|....:|:...|.          .||...   .
  Fly   468 ITSHKVQFGGVGG-RVKIDCLAFSIPKAEHILWSFEGKIINMSSADPDIYIFEEHHLPEGV---R 528

Human   458 GSLLISPTHISDAGTYTCLATNSRGVDEASADL------------------------------VV 492
            .:|:|..:..:..|.|.|...||.|.|.....|                              :|
  Fly   529 AALIIRDSKATHFGKYNCTVMNSYGGDSLVITLLREPGNIPVLLVVMGSMFCVAIILMIVMIIIV 593

Human   493 WARTRITKPPQDQSVIKGTQAS-----------------------------MVCGVTHDPRVTIR 528
            :.:.|..|.|....||  .:||                             :...:|..|...: 
  Fly   594 YRKRRSRKKPMPADVI--PEASRGGDKLNELKSELRSKAYDVEYSEAGGDGLAINLTQSPMPDV- 655

Human   529 YIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAP 593
               :..|||||......::.|        :.:|||.|         |...:|..|  ::.|.:..
  Fly   656 ---QMKGATLGVPLAGPVKFD--------ERFSGDFG---------GDRYNRQCH--IKNLKNQQ 698

Human   594 E-----HPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLL------------- 640
            |     .|.|                  :|.:....|.|:.|........::             
  Fly   699 ETAYKGSPQA------------------NGYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLKNGG 745

Human   641 --ASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASG-- 701
              ::..|.:.:.||.|              ...|.|      ...|||........|:..::|  
  Fly   746 MNSATLPHSAAATVNG--------------GGAGNG------GGASLPRNQRHEIQQSQQSNGFL 790

Human   702 ----------------------RTNQSIMIQWQPPPES--------------------HQNGILK 724
                                  |||.|::....||..:                    |.||.||
  Fly   791 GQPLLQNGIDSRFSAIYGNPYLRTNSSLLPPLPPPSTANPAATPAPPPYHAARHGHAHHANGGLK 855

Human   725 GYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQG 789
            .::....:...|||         :||          .|......:..|.|.||           |
  Fly   856 HFVGGAVITTSPVG---------NVN----------INGGGGGGSTPSGGGGV-----------G 890

Human   790 VPTVPPGNVHAEATNSTTIRFTWNA-----------------PSPQFI---NG 822
            |.....|:|...::|.|....|..|                 ||.|||   ||
  Fly   891 VGVAAGGSVSGSSSNLTASSNTLAATPLAGGGVGNSGQCAQSPSGQFILSNNG 943

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845 23/115 (20%)
IG_like 40..109 CDD:214653 19/102 (19%)
I-set 120..203 CDD:254352 18/93 (19%)
Ig 132..210 CDD:299845 16/88 (18%)
IG_like 222..304 CDD:214653 25/92 (27%)
IGc2 233..286 CDD:197706 16/54 (30%)
I-set 308..397 CDD:254352 22/91 (24%)
Ig 326..394 CDD:143165 17/70 (24%)
I-set 402..492 CDD:254352 23/130 (18%)
Ig 416..492 CDD:299845 20/116 (17%)
Ig 502..586 CDD:299845 20/112 (18%)
IG_like 502..586 CDD:214653 20/112 (18%)
FN3 590..681 CDD:238020 13/110 (12%)
FN3 693..786 CDD:238020 23/136 (17%)
FN3 794..890 CDD:238020 13/49 (27%)
FN3 895..983 CDD:238020
FN3 993..1087 CDD:238020
FN3 1099..1194 CDD:238020
FN3 1201..1290 CDD:238020
FN3 1301..1394 CDD:238020
FN3 1400..1484 CDD:238020
FN3 1503..1616 CDD:238020
FN3 1626..1719 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729
FN3 1724..1805 CDD:238020
FN3 1837..1916 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
kirreNP_001245505.1 Ig 87..183 CDD:299845 22/100 (22%)
IG_like 88..182 CDD:214653 21/98 (21%)
C2-set_2 189..279 CDD:285423 21/104 (20%)
Ig_2 307..379 CDD:290606 21/79 (27%)
I-set 382..462 CDD:254352 22/91 (24%)
IGc2 396..446 CDD:197706 14/60 (23%)
Ig 466..561 CDD:299845 22/98 (22%)
IG_like 478..561 CDD:214653 19/86 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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