DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and sdk

DIOPT Version :9

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster


Alignment Length:2289 Identity:857/2289 - (37%)
Similarity:1193/2289 - (52%) Gaps:235/2289 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    25 SPYFKTEPVRT-QVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTHAGF 88
            :|.|.|.|..: .:..||:..:|.|.|.|.....::||.:...:..||....|...|..|..||.
  Fly    71 APRFTTHPSSSGSIVSEGSTKILQCHALGYPQPTYRWLKDGVPVGDFSSSQFYRFHSTRREDAGS 135

Human    89 YRCIVRNRMGALLQRQTEVQVAYMGSFEE-GEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGR 152
            |:||.||..|::...:::|.|||||.||. .|...:|..|..|:...|.|.|.|.|.|.|..:..
  Fly   136 YQCIARNDAGSIFSEKSDVVVAYMGIFENTTEGRLTVISGHPAIFDMPPIESIPVPSVMWQSEDG 200

Human   153 KIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTI 217
            .:....:.|.|..|.|:|||....|...|..:|:|.:.|..::|..:.|.|.  |.|...:||.|
  Fly   201 PLNYDIKYAFTHANQLIILSADENDRKGYRAKAINTQLGKEESSAFVHLNVS--GDPYIEVAPEI 263

Human   218 IIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDH------NRRLTIPNPTG 276
            |:.|::..|..||..|.|:|:||||||.:|..:|.|||:.:......|      ||.|.:.....
  Fly   264 IVRPQDVKVKVGTGVVELQCIANARPLHELETLWLKDGLAVETAGVRHTLNDPWNRTLALLQANS 328

Human   277 SDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSIT 341
            |.:|.|.|:..|||...|:|...|.|.:||||.|..........|....|.:.|...|.|.|.:.
  Fly   329 SHSGEYTCQVRLRSGGYPAVSASARLQILEPPLFFTPMRAETFGEFGGQVQLTCDVVGEPTPQVK 393

Human   342 WYKDAAVVEVE-KLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT------- 398
            |:::|..|:.. :..|:....|..|.|..|:.||..||||.|.|.|||...||:|.|.       
  Fly   394 WFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDAAMFQCLAINEAGENSASTWLRVKTKTAKNR 458

Human   399 --------------------------------------SIAPNITRGPLDSTVIDGMSVVLACET 425
                                                  :.||.:...|.:.|.:||....::|..
  Fly   459 VKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKEFRFASAPIMELPPQNVTALDGKDATISCRA 523

Human   426 SGAPRPAITWQKGERILA--SGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 488
            .|:|.|.|||...|..|.  |..||:     ||||.||||.....|||.|.|:..|..|..:..|
  Fly   524 VGSPNPNITWIYNETQLVDISSRVQI-----LESGDLLISNIRSVDAGLYICVRANEAGSVKGEA 583

Human   489 DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDG-ATLGTESHPRIRLDRNG 552
            .|.|..||:|.:||.|.:|:.|..|::.|.|:.||.|.....|.::| ::....:..||.:..:|
  Fly   584 YLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYNIDWYREGQSSTPISNSQRIGVQADG 648

Human   553 SLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEH-PVATLSTVERRAINLTWTKPF 616
            .|.|....:.|:|:|.|.|.|.|||::|:|.|.|.:||..|.: .|..|...::|:||::||..|
  Fly   649 QLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFPPSNVKVERLPEPQQRSINVSWTPGF 713

Human   617 DGNSPLIRYIL---EMSE-NNAP-----WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVG 672
            |||||:.::|:   |:|| ...|     |...|::|......:.::.|..|..||||:.|||.||
  Fly   714 DGNSPISKFIIQRREVSELGPVPDPLLNWITELSNVSADQRWILLENLKAATVYQFRVSAVNRVG 778

Human   673 KGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAG--- 734
            :|..|:.:..|.||:|.|:.||...:.|.|:...|:.|||||.|.|:||.:.|||:||.|.|   
  Fly   779 EGSPSEPSNVVELPQEAPSGPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNN 843

Human   735 LPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS--SKVTEWTLQGVPTVPPGN 797
            :|..||  |||:....|.|:::||.|.:|.:::||||:.|:|||:  ||:.  |.:|||..||.|
  Fly   844 VPWSYQ--NITNEAQRNFLIQELITWKDYIVQIAAYNNMGVGVYTEGSKIK--TKEGVPEAPPTN 904

Human   798 VHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPE------QEEEVTMVTARPNFQDSI--H 854
            |..||.|||..|..|..|:||.|||||||||:.||:..      ::.|..|.|..|:..|.:  .
  Fly   905 VKVEAINSTAARCRWTPPNPQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQ 969

Human   855 VGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPG 919
            ...:.||:|||||..||||||.||||..|:...|.|.:|||..|..|.|.::.|.|:||.|..|.
  Fly   970 TAILGGLEKFTEYNISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRSVKVLWAPPR 1034

Human   920 EKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 984
            ..|||||||.:.::..:|.:|..:..|.....|..|..|.|.|.|..|:.|.|..|.|....:||
  Fly  1035 ASNGILTGYTVRYQVKDRPDTLKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIPKTATI 1099

Human   985 SSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049
            .|||.|.||..||.|.:|||...||.|||.||:||.:||::|.||.|   ......|..|.:: |
  Fly  1100 QSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSITKWKVEGQ---TARNMTWFTICEI-N 1160

Human  1050 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLW 1114
            :|||.::.|..|.|||.|..|:...|:||:|.||:.::..||:||.|...|.||::|..|...|.
  Fly  1161 DPDAETLTVTGLVPFTQYRLRLSASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLR 1225

Human  1115 LRWMPLPEMEYNGNPESVGYKIKYS---RSDGHGKTL--SHVVQDRVERDYTIEDLEEWTEYRVQ 1174
            :||:||.:.|:.|||.  ||.|.|.   ::.|..|.:  |.|::|.....:.::.|||||.|.|:
  Fly  1226 VRWIPLQQTEWYGNPR--GYNISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVK 1288

Human  1175 VQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMY 1239
            :.|.|.:|....|.|.|.||||:|||.||.:|.|.||:|::::|:|.|||...|||.:.||||.|
  Fly  1289 MNACNDVGCSKESDTAVERTREAVPSYGPLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFY 1353

Human  1240 KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1304
            ...|...|.....:..|::.:..||.|.|||:|.|||||:||:|:|:.|.|||..:|.:|.||.|
  Fly  1354 AAADRGQQVLHKTIPNNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVP 1418

Human  1305 MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPES 1369
            ..:.||:|..|..|:||..|..|||.|||||:|:.||.:.....:.| ..||.|.:.||.|.|..
  Fly  1419 SNVSFPDVSLTMARIIWDVPVDPNGKILAYQVTYTLNGSAMLNYSRE-FPPSDRTFRATELLPGK 1482

Human  1370 VYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRY 1434
            .|.|..|||||.|||:.|.|||.||..|:|||.||.|.:.:..::|..:..||.||.||.:|:||
  Fly  1483 YYSFSCTAQTRLGWGKIATALVYTTNNRERPQAPSVPQISRSQIQAHQITFSWTPGRDGFAPLRY 1547

Human  1435 YTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQA 1499
            ||::.|| ..|||......|..:.|||....|:|:.:|:||::||||:|.|.||.||..:.||.|
  Fly  1548 YTVEMRE-NEGRWQPLPERVDPSLSSFTAVGLRPYMTYQFRIQATNDLGPSAFSRESVIVRTLPA 1611

Human  1500 APDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILL--GFRIRYRELLYEGLRGFTLRGINNPGA 1562
            ||......|.|.|.|||||.::|........||...  |:||     ||:.|..|         .
  Fly  1612 APAVGVGGLKVVPITTTSVRVQWSALETALWNGDASTGGYRI-----LYQQLSDF---------P 1662

Human  1563 TWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAP 1627
            |..:.|....:..::..|:.   |.:|.:.|.|||.:..:|:.|.||::||..|:|||||||..|
  Fly  1663 TALQSTPKTDVHGINENSVV---LSDLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEP 1724

Human  1628 RNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYF--------------WEAQRGNLTERVKTL 1678
            |.|.....::|::.:.|:||....|||||.|||||:              ||       |.::.:
  Fly  1725 RAVDAAPISSTEVRLLWKPPKQSMQNGDILGYKIYYLVTYSPQALEPGRKWE-------EEIEVV 1782

Human  1679 FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVS 1743
            .....|..|..|..:|.|.:.:.|||.|||||||.|...:|....||||..::||::|..|:.|:
  Fly  1783 SATATSHSLVFLDKFTEYRIQLLAFNPAGDGPRSAPITVKTLPGVPSAPLHLRFSDITMQSLEVT 1847

Human  1744 WEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT-FT 1807
            |:.|:|.||.:.||.:.||.....:..||.|...|...:   |:|::|.|.|||.|.:||:| ..
  Fly  1848 WDPPKFLNGEILGYLVTYETTEENEKFSKQVKQKVSNTT---LRVQNLEEEVTYTFTVRAQTSVD 1909

Human  1808 YGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDIL 1872
            |||.|..||||||.:|:|..|...|:.:..|::.:||.:|..|:|||..|:|||:..|:..|..:
  Fly  1910 YGPGISENVTTGPQDGSPVAPRDLILTKTLSSVEMHWINGPSGRGPILGYLIEAKKRDDSRWTKI 1974

Human  1873 IKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTP--SSPSQSVPAQ--------KANPFY 1927
            .:.....:..:|.|..||.|..:|.|||||.|.||...|  |..|...|::        :..|||
  Fly  1975 EQTRKGMMQDFTVSYHILMPSTAYTFRVIAYNRYGISFPVYSKDSILTPSKLHLEYGYLQHKPFY 2039

Human  1928 EEWWFLVVIALVGLIFILLLVFVLIIRGQSKKY---AKKTDSGNSAKSGALGHSEMMSLDESSFP 1989
            .:.||:|.:|...::.|::::.||.::.:|.||   |:||          |..|..||:||....
  Fly  2040 RQTWFMVSLAATSIVIIVMVIAVLCVKSKSYKYKQEAQKT----------LEESMAMSIDERQEL 2094

Human  1990 ALELNNRRLSV---------------KNSFCRKN------GLYT-RSPPRPSPGSLHY-SDEDVT 2031
            ||||...|..|               ..:..||:      |::. :|||||||.|:.| |||:..
  Fly  2095 ALELYRSRHGVGTGTLNSVGTLRSGTLGTLGRKSTSRPPPGVHLGKSPPRPSPASVAYHSDEESL 2159

Human  2032 KYNDLIPAESSSLTEKPSEISDSQGSD-SEYEVDSNHQKAHSFVNHYIS-DPTYYNSWRRQQKGI 2094
            |..|..| :.||:||||||:|.|:.|. ||.|.:|.....|||||||.: :.:...||::.:.  
  Fly  2160 KCYDENP-DDSSVTEKPSEVSSSEASQHSESENESVRSDPHSFVNHYANVNDSLRQSWKKTKP-- 2221

Human  2095 SRAQAY-SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLA 2158
              .:.| |||:|   ||:.:.|   .|...|.:.....:|                         
  Fly  2222 --VRNYSSYTDS---EPEGSAV---MSLNGGQIIVNNMAR------------------------- 2253

Human  2159 PGSRAPIAGFSSFV 2172
              ||||:.||||||
  Fly  2254 --SRAPLPGFSSFV 2265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig 27..109 CDD:299845 25/82 (30%)
IG_like 40..109 CDD:214653 22/68 (32%)
I-set 120..203 CDD:254352 24/82 (29%)
Ig 132..210 CDD:299845 23/77 (30%)
IG_like 222..304 CDD:214653 32/87 (37%)
IGc2 233..286 CDD:197706 22/58 (38%)
I-set 308..397 CDD:254352 30/89 (34%)
Ig 326..394 CDD:143165 25/68 (37%)
I-set 402..492 CDD:254352 34/91 (37%)
Ig 416..492 CDD:299845 30/77 (39%)
Ig 502..586 CDD:299845 29/84 (35%)
IG_like 502..586 CDD:214653 29/84 (35%)
FN3 590..681 CDD:238020 36/100 (36%)
FN3 693..786 CDD:238020 43/97 (44%)
FN3 794..890 CDD:238020 49/103 (48%)
FN3 895..983 CDD:238020 31/87 (36%)
FN3 993..1087 CDD:238020 41/93 (44%)
FN3 1099..1194 CDD:238020 36/99 (36%)
FN3 1201..1290 CDD:238020 40/88 (45%)
FN3 1301..1394 CDD:238020 44/92 (48%)
FN3 1400..1484 CDD:238020 35/83 (42%)
FN3 1503..1616 CDD:238020 33/114 (29%)
FN3 1626..1719 CDD:238020 36/106 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 12/21 (57%)
FN3 1724..1805 CDD:238020 32/80 (40%)
FN3 1837..1916 CDD:238020 30/80 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067 15/28 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172 19/74 (26%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172 4/5 (80%)
sdkNP_001284756.1 Ig 71..157 CDD:299845 26/85 (31%)
I-set 72..150 CDD:254352 25/77 (32%)
Ig 172..245 CDD:299845 22/72 (31%)
IG_like 280..356 CDD:214653 28/75 (37%)
Ig 280..343 CDD:299845 23/62 (37%)
IG_like 375..450 CDD:214653 27/74 (36%)
Ig 378..447 CDD:143165 25/68 (37%)
Ig 506..587 CDD:299845 33/85 (39%)
IG_like 506..587 CDD:214653 33/85 (39%)
I-set 592..682 CDD:254352 31/89 (35%)
Ig 595..682 CDD:299845 30/86 (35%)
FN3 686..789 CDD:238020 36/102 (35%)
FN3 798..893 CDD:238020 43/98 (44%)
FN3 901..1005 CDD:238020 49/103 (48%)
fn3 1011..1094 CDD:278470 30/82 (37%)
FN3 1108..1202 CDD:238020 41/97 (42%)
FN3 1210..1308 CDD:238020 36/99 (36%)
fn3 1317..1402 CDD:278470 38/84 (45%)
FN3 1415..1507 CDD:238020 44/92 (48%)
FN3 1513..1608 CDD:238020 41/95 (43%)
fn3 1617..1708 CDD:278470 31/107 (29%)
FN3 1722..1823 CDD:238020 36/107 (34%)
FN3 1828..1920 CDD:238020 39/94 (41%)
FN3 1927..2016 CDD:238020 32/88 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 96 1.000 Domainoid score I7350
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10406
Inparanoid 1 1.050 1354 1.000 Inparanoid score I140
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46050
OrthoDB 1 1.010 - - D134749at2759
OrthoFinder 1 1.000 - - FOG0002891
OrthoInspector 1 1.000 - - otm41838
orthoMCL 1 0.900 - - OOG6_104033
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4749
SonicParanoid 1 1.000 - - X1909
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.770

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