DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SDK2 and Dscam4

DIOPT Version :10

Sequence 1:NP_001138424.1 Gene:SDK2 / 54549 HGNCID:19308 Length:2172 Species:Homo sapiens
Sequence 2:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster


Alignment Length:1872 Identity:429/1872 - (22%)
Similarity:700/1872 - (37%) Gaps:496/1872 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    48 CMAEGSWPLEFKWLHNNRELTKFS-LEY-----RYMITSLDRTHAGFYRCIVRNRMGALLQRQTE 106
            |:..|....:..|||:.:.:.:.: :|.     |.:|..:.:...|.|:|.|.|.. ..:|...|
  Fly   351 CIVSGHPVHDVNWLHDGKPILRDNRVEILTDPPRLIIKKVQKEDPGMYQCFVSNEW-EQIQSTAE 414

Human   107 VQVA-----YMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIA----I 162
            :|:.     .:..|.|    |::..|....::.....: |.||.||..||..||.|||..    :
  Fly   415 LQLGDASPELLYWFSE----QTLQPGPTVSLKCVATGN-PLPQFTWSLDGFPIPDSSRFLVGQYV 474

Human   163 TLENTLV----ILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKN 223
            |:.:.::    |.:....|.|.|...|   :|...|.|....:.:..:        |.|...||.
  Fly   475 TIHDDVISHVNISNVKEEDGGEYTCTA---QNAIGKVSHSAKVNIYGL--------PYIREMPKI 528

Human   224 TSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGS----------D 278
            |.:  ..|::.::|.....|:.|:|  |::||..|     ..|||....| .|:          |
  Fly   529 TGI--SGSDLIVKCPVAGYPIDKIH--WERDGQTL-----PINRRQRAYN-NGTLIIEQLQRLED 583

Human   279 AGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVV--DIPCQ-AKGVPPPSI 340
            ||.|.|.|  ::....:..|...:.||.||:.:  |.:.:|..:.:.:  .|.|| .:|..|.|.
  Fly   584 AGTYTCMA--QNKQKQTSRRNVEIQVLVPPKIM--PIQAMTNMLREGMRAAISCQILEGDLPVSF 644

Human   341 TWYKDAAVV-----EVEKLTRFRQRND--GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT 398
            .|.::...:     ||     ||:.::  ..|.|..:..|.:|.:.|.|.|.||..:.:..|.| 
  Fly   645 RWERNGKPLIGTGNEV-----FRRLDEYSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTV- 703

Human   399 SIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK------GE--RILASGSVQLPRFTPL 455
            ::.|.....|.||:...|..|:|.|::||.|.|.|||:|      ||  ..|...:|||     .
  Fly   704 NVPPKWILEPKDSSAQAGADVLLHCQSSGYPTPTITWKKAIGPTPGEYKDFLYEPTVQL-----F 763

Human   456 ESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRI-----TKPPQDQSVIKGTQASM 515
            .:|::..........|.:.|.|.|:.|   :....|::.:..:     ||..| .||.||.|..:
  Fly   764 PNGTIFFKKISKESQGHFLCEAKNNIG---SGVSKVIFLKVNVPAHFQTKTKQ-ISVAKGKQVHV 824

Human   516 VCGVTHDPRVTIRYIWEKDGATL-----GTESHPRIR---LDRN--GSLHISQTWSGDIGTYTCR 570
            .|.|..|..:..::   |..||.     ..:|...||   ||..  ..|.||.|:..|.|.|.|:
  Fly   825 QCNVQGDNPIDFKW---KIQATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGIYICQ 886

Human   571 VISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRY------ILEM 629
            ..:|.|.|..|..|.|:::|..|::  ..:::.:.|::.|||::||.||||:..|      |.::
  Fly   887 ASNAFGQDEMSIQLIVQEVPEQPKN--LRINSQQSRSLQLTWSQPFAGNSPIEEYHIYYKQISDI 949

Human   630 SENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPP 694
            .:|....|:..|.     |.:.::.|.||::|..|:.|.|.:|..:|| :..:|:..||.|:.||
  Fly   950 WQNAEHLTIAGAQ-----TVINIQQLRPAKAYHIRMSAENKLGASEFS-EVVQVTTLEEVPSGPP 1008

Human   695 QNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLP--------VGYQFKNITDADVNN 751
            ..|.|..:::..|.:.|..|...|.||||.||.:.|.::..|        .|:.||.:   :|.:
  Fly  1009 LAVRAEPKSSTEIFVTWDAPERDHWNGILLGYYVGYQMSLTPEDKEVNPTQGFSFKTV---EVRS 1070

Human   752 -----LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFT 811
                 .:|.:|..:|.|.:.|.||.|.|.|..|.::...|::.||:.||.:...:...||:|..|
  Fly  1071 HFGGETVLANLNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESPQCDVLGSTSIYIT 1135

Human   812 WNAPSPQFINGINQGYKL--IAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCF 874
            |:.|.....||..:|||:  |:.:...|.:..:|.:...:..      :..|:|:|.|...||.:
  Fly  1136 WSPPDIDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYVT------IENLRKYTNYTVWVLAY 1194

Human   875 TTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTN 939
            |..|||.::.|...|||||||.....:.......:.:.:||..|...||.:|||           
  Fly  1195 TKVGDGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWLPPDLPNGDITGY----------- 1248

Human   940 TRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNI 1004
               |.|:                       :|...|:        ..|....|.||...:..:..
  Fly  1249 ---TFYM-----------------------SMLEGGR--------EEGTHKRLLGPFVEMHETVR 1279

Human  1005 GPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLN--PFTCY 1067
            ...|.|.||            ||..:.  .:||||:            .:.:.||..|  |....
  Fly  1280 TQESATYQF------------WLTAST--KMGEGEK------------TQVVTVPPNNKVPARIV 1318

Human  1068 SFRMRQVNIVGTSPPSQ----PSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGN 1128
            ||..|.|     :|..:    |.||:.        |||.|::           |           
  Fly  1319 SFSQRIV-----TPWKEHLELPCRKVG--------APAPVTI-----------W----------- 1348

Human  1129 PESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGS------GPWS 1187
                       |.|||....|  .:..:.::.|:        |..:.||.:| |:      ..|.
  Fly  1349 -----------RQDGHNMETS--ARKTIAKNGTL--------YMKECQASDA-GNYTCSVENTWG 1391

Human  1188 Q-TVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW 1251
            : .:|......||...| |::.:...:.|:|:.|.:  .:.....:|||.:.||..:.|     |
  Fly  1392 KDEIVYNIVVKVPPEAP-NLTVINAYTDSLLLEWMD--NSHGGSPILGYVINYKRDNGD-----W 1448

Human  1252 --LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP---------SHPPILERTLDDVPGPPM 1305
              |...:.:.|..||.|.....|::.:.|:.:||.|.|         .:||:..:....:..   
  Fly  1449 EELQVDSKTTSHLLTNLWCGTRYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQMITN--- 1510

Human  1306 GILFPEVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPES 1369
                   .:||| ..|.......|. ||.:.|..|:...::.......:.|:.|.||.:.|.|.:
  Fly  1511 -------NSTSV-TCWLDSWGDGGCGILYFMIESRVYGRSSWAVVSNHIPPTERIYTVSDLVPGT 1567

Human  1370 VYLFRITAQTRKGWGEAA-EALVVTTE----KRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGL 1429
            .|..::||....|...|. ....::|:    ..|...|.|.                       |
  Fly  1568 KYQLKVTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSH-----------------------L 1609

Human  1430 SPVRYYT------------------------IQTRELPSGRWALHSASVSHNAS----------- 1459
            |.:.:|.                        ::.|:|.| :..|.|:|:|.:.|           
  Fly  1610 SDLPFYANFKLLLPICFSLLMLLALIGAALFLRKRKLAS-QARLASSSMSESPSLANLQNKQNRD 1673

Human  1460 -SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQ 1523
             .::..|..|.||.. |...:||.|....:|.:|             .|..:.|:.|..  :..|
  Fly  1674 QQYLAVRCNPGTSAP-RGSNSNDSGSFGKAEGNE-------------YIEDICPYATFQ--LNKQ 1722

Human  1524 PPAEDKING-ILLGFRIRYRELLYEGLRG-FTLRGI----------------------------- 1557
            ..:|...:| :..|        .|..:|| |....:                             
  Fly  1723 TYSESSYSGNVYSG--------PYHSVRGSFVYHDVKPESYHSKEPEYTKVRRKVGRLRDPHSES 1779

Human  1558 ---NNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAV---------GEGPS 1610
               :|||:|.:|:..:.::    ...:|:|  |.|......::.....|:.         .|..|
  Fly  1780 QESDNPGSTDSEVRKILTL----HIPITEY--DTLGSESDNDVSARALNSAKYRAQRDTQDETSS 1838

Human  1611 SPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERV 1675
            |       .|..||:..|.               ..||..::.|...|        ..|....|.
  Fly  1839 S-------SETTPTSMTRK---------------SKPPFAARKGGKPG--------TSGKRHVRS 1873

Human  1676 KTLFLAENSVKLKNLTGYTA----YMVSVAAFNAAGDGPRSTPTQGQTQQAA 1723
            .:.:.:.|.....:::.|..    ::...|.|:.|.|   .|.||...:..|
  Fly  1874 SSGYSSHNEETTFSISNYPPNYQDHINPPARFSDAND---KTKTQTSPRMRA 1922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SDK2NP_001138424.1 Ig_3 26..95 CDD:464046 12/52 (23%)
Ig 121..197 CDD:472250 22/83 (27%)
Ig strand B 130..134 CDD:409353 0/3 (0%)
Ig strand C 144..148 CDD:409353 2/3 (67%)
Ig strand E 166..170 CDD:409353 0/7 (0%)
Ig strand F 180..185 CDD:409353 1/4 (25%)
Ig strand G 193..196 CDD:409353 1/2 (50%)
Ig 233..286 CDD:409353 18/62 (29%)
Ig strand B 233..237 CDD:409353 0/3 (0%)
Ig strand C 248..252 CDD:409353 1/3 (33%)
Ig strand E 267..271 CDD:409353 2/3 (67%)
Ig strand F 281..286 CDD:409353 2/4 (50%)
Ig 308..397 CDD:472250 24/98 (24%)
Ig strand B 326..330 CDD:409353 1/5 (20%)
Ig strand C 339..343 CDD:409353 1/3 (33%)
Ig strand E 363..367 CDD:409353 1/3 (33%)
Ig strand F 377..382 CDD:409353 1/4 (25%)
Ig strand G 390..393 CDD:409353 0/2 (0%)
Ig 404..492 CDD:472250 27/95 (28%)
Ig strand B 419..423 CDD:409353 2/3 (67%)
Ig strand C 432..436 CDD:409353 2/3 (67%)
Ig strand E 458..462 CDD:409353 1/3 (33%)
Ig strand F 472..477 CDD:409353 1/4 (25%)
Ig strand G 485..488 CDD:409353 0/2 (0%)
Ig_3 497..571 CDD:464046 27/88 (31%)
FN3 <596..1028 CDD:442628 119/452 (26%)
FN3 960..>1337 CDD:442628 80/401 (20%)
FN3 1188..>1522 CDD:442628 76/387 (20%)
FN3 1504..1608 CDD:214495 21/146 (14%)
FN3 <1577..1932 CDD:442628 28/160 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1707..1729 5/17 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2039..2067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2098..2172
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2166..2172
Dscam4NP_001261571.1 Ig 31..124 CDD:472250
Ig strand B 50..54 CDD:409353
Ig strand C 63..66 CDD:409353
Ig strand E 82..86 CDD:409353
Ig strand F 102..107 CDD:409353
Ig strand G 115..119 CDD:409353
Ig 235..326 CDD:472250
Ig strand B 253..257 CDD:409353
Ig strand C 266..270 CDD:409353
Ig strand E 292..296 CDD:409353
Ig strand F 306..311 CDD:409353
Ig strand G 319..322 CDD:409353
IgC2_3_Dscam 329..417 CDD:409549 15/66 (23%)
Ig strand A 330..335 CDD:409549
Ig strand A' 338..342 CDD:409549
Ig strand B 345..355 CDD:409549 1/3 (33%)
Ig strand C 360..366 CDD:409549 2/5 (40%)
Ig strand C' 367..370 CDD:409549 0/2 (0%)
Ig strand E 383..389 CDD:409549 2/5 (40%)
Ig strand F 396..404 CDD:409549 4/7 (57%)
Ig strand G 407..417 CDD:409549 2/9 (22%)
IgI_4_Dscam 422..516 CDD:409548 25/101 (25%)
Ig strand A' 430..434 CDD:409548 2/7 (29%)
Ig strand B 437..446 CDD:409548 0/8 (0%)
Ig strand C 451..457 CDD:409548 4/5 (80%)
Ig strand C' 459..462 CDD:409548 1/2 (50%)
Ig strand D 467..475 CDD:409548 1/7 (14%)
Ig strand E 479..488 CDD:409548 1/8 (13%)
Ig strand F 495..503 CDD:409548 3/10 (30%)
Ig strand G 506..516 CDD:409548 2/9 (22%)
IgI_5_Dscam 520..607 CDD:409550 26/98 (27%)
Ig strand A 520..522 CDD:409550 1/1 (100%)
Ig strand A' 527..531 CDD:409550 2/3 (67%)
Ig strand B 534..541 CDD:409550 1/6 (17%)
Ig strand C 548..554 CDD:409550 3/7 (43%)
Ig strand C' 555..557 CDD:409550 1/1 (100%)
Ig strand D 564..568 CDD:409550 1/3 (33%)
Ig strand E 571..577 CDD:409550 1/5 (20%)
Ig strand F 585..593 CDD:409550 4/9 (44%)
Ig strand G 597..607 CDD:409550 1/9 (11%)
Ig 610..703 CDD:472250 25/99 (25%)
Ig strand B 629..633 CDD:409353 1/3 (33%)
Ig strand C 643..647 CDD:409353 1/3 (33%)
Ig strand E 669..673 CDD:409353 1/3 (33%)
Ig strand F 683..688 CDD:409353 1/4 (25%)
Ig strand G 696..699 CDD:409353 0/2 (0%)
IgI_7_Dscam 706..801 CDD:409546 29/102 (28%)
Ig strand A 706..710 CDD:409546 1/3 (33%)
Ig strand A' 715..719 CDD:409546 2/3 (67%)
Ig strand B 722..731 CDD:409546 3/8 (38%)
Ig strand C 737..743 CDD:409546 3/5 (60%)
Ig strand C' 749..752 CDD:409546 2/2 (100%)
Ig strand D 760..763 CDD:409546 3/7 (43%)
Ig strand E 766..772 CDD:409546 1/5 (20%)
Ig strand F 779..787 CDD:409546 3/7 (43%)
Ig strand G 792..801 CDD:409546 1/8 (13%)
Ig 804..889 CDD:472250 27/88 (31%)
Ig strand B 822..826 CDD:409353 0/3 (0%)
Ig strand C 835..839 CDD:409353 0/6 (0%)
FN3 <850..1254 CDD:442628 129/457 (28%)
Ig strand F 882..887 CDD:409353 2/4 (50%)
FN3 906..999 CDD:238020 29/100 (29%)
fn3 1117..1203 CDD:394996 26/91 (29%)
FN3 1185..>1580 CDD:442628 117/541 (22%)
FN3 1405..1494 CDD:238020 23/96 (24%)
Blue background indicates that the domain is not in the aligned region.

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