Protein Alignment HMGCLL1 and Hmgcl

DIOPT Version :10

• Sequence 1: NP_061909.2
• Gene: HMGCLL1 / 54511
• HGNCID: 21359
• Length: 370
• Species: Homo sapiens
• Sequence 2: NP_609089.1
• Gene: Hmgcl / 33978
• FlyBaseID: FBgn0031877
• Length: 323
• Species: Drosophila melanogaster
• Alignment Length: 289
• Identity: 179/289 - (61%)
• Similarity: 232/289 - (80%)
• Gaps: 0/289 - (0%)

Human    78 VKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQ 142
            |:|||||||||||||..::|...|||.||:||:|||..||.|||||::|||||.|:.||:|||.:
  Fly    26 VRIVEVGPRDGLQNEPKLLPAATKIELINQLSETGLRTIEATSFVSAKWVPQMGDNAEVLKGIRK 90

Human   143 YPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNI 207
            ..|:.||||||||:||..|:.|||.|::||||||::||.||:||:..|::.:|:.|:|:|:...:
  Fly    91 VTGISYPVLTPNLKGFESALEAGAEEVAVFGAASDAFSLKNVNCTAAEAIERFKPVLKAAQKHGV 155

Human   208 PARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPP 272
            ..|||||..:||||||::.|..|.:|.:.||.||||||||||||||||||:|:|||:.|.|.:|.
  Fly   156 RVRGYVSTVVGCPYEGAVAPSAVVKVVEALYQMGCYEISLGDTIGVGTPGTMRRMLDEVTKVVPA 220

Human   273 GALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNT 337
            ..|||||||||||||:|||.:|..||.||||:||||||||||||||||.||||::|:|:|:||:|
  Fly   221 KDLAVHCHDTYGQALSNILVSLDYGIRVVDSSVSGLGGCPYAKGASGNAATEDVVYLLHGMGLDT 285

Human   338 GVNLYKVMEAGDFICKAVNKTTNSKVAQA 366
            ||||.|:::.|.:||..:.:|:.|||.:|
  Fly   286 GVNLDKLIQVGRYICTELGRTSESKVNRA 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HMGCLL1	NP_061909.2	TIM-like beta/alpha barrel domains	56..366	CDD:473867	178/287 (62%)
Hmgcl	NP_609089.1	DRE_TIM_HMGL	28..300	CDD:163676	171/271 (63%)