DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZDHHC13 and zdhhc13

DIOPT Version :9

Sequence 1:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens
Sequence 2:	NP_001008650.2	Gene:	zdhhc13 / 494107	ZFINID:	ZDB-GENE-041212-79	Length:	645	Species:	Danio rerio

Alignment Length:	635	Identity:	323/635 - (50%)
Similarity:	432/635 - (68%)	Gaps:	34/635 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     2 EGPG------LGSQCR----NHSHG---PH---------PPGFGRYGICAHENKELANAREALPL 44
            ||.|      :|..|.    .||||   .|         |.||....:....:......:.:.|
Zfish     5 EGDGSHSHGHMGDSCHGHGGGHSHGHGHSHGGSGFGGFMPAGFHGQLVPGPMDPTQQPRKSSHP- 68

Human    45 IEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVD 109
             ||||:.||:||||:|..|||||||||||||||||||||:||||||||||.|:||:|||||||:|
Zfish    69 -EDSSSWDIIKATQFGALERCKELVEAGYDVRQPDKENVTLLHWAAINNRADIVKYYISKGAVID 132

Human   110 QLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
            ||||||||||||||||||||.|||.|:::||||:|.||||:..:|||||||:|||.|||::|||.
Zfish   133 QLGGDLNSTPLHWAIRQGHLSMVIQLMRYGADPSLADGEGYRGLHLAVLFQNMPIAAYLMAKGQE 197

Human   175 VNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEA 239
            |::.|:||||||||:|.|:||||||.||:|.|.|:|.|||:::|:|||.||.||||::|..||||
Zfish   198 VDLPDLNGQTPLMLAAQKIIGPEPTNFLIKCNASVNAVDKVNRNSPLHCAVLAGNVDSVHILLEA 262

Human   240 GSSLDIQNVKGETPLDMALQNKNQLIIHML---KTEAKMRANQKFRLWRWLQKCELFLLLMLSVI 301
            |:|:|:||..|.|.:|:|.|..:.|:||||   ||| :::||.  ...:.|.:.::.|..:.||:
Zfish   263 GASVDMQNDNGHTAIDLAQQVHSPLLIHMLSVVKTE-RIKANS--ACLKLLNRYKVCLQSVFSVV 324

Human   302 TMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFL--VGYKNLVYLPTAFLLSSVFWIFMTWF 364
            .:.|.|.|||..::||||||.||..:..:.:|..|.|  |..::|:  |:..|::||||:.:||.
Zfish   325 VVGAFGAILDMRTESWLLKGILLACIMAVINLASRQLATVAVRSLI--PSTGLIASVFWMVVTWV 387

Human   365 ILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCT 429
            :.|.||...|.....|..:|.|.||::.::..||||..||:|||||.||:.|||.|.||.|.|||
Zfish   388 LWFLPDEPSAAVQMLFTVNITAVLYYYIRSCRTDPGHVKATEEEKKKNIVVLAEAGCLDPRIFCT 452

Human   430 SCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLS 494
            ||::|||:|:.||..||.|||:.|.|.:|...|||..||.:::.||..|:.:|.|:.|||..|.|
Zfish   453 SCMMRKPMRANHCFSCNACVAKQDHHSIWINGCIGARNHPFFVLFLVALNFLCIWMFYGSITYWS 517

Human   495 SHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQ 559
            .||...:.|:|:|..|..::.||||:||:.....||.:|::.||:.||:||||||||:.||.:|.
Zfish   518 RHCPLHYSEEGIWGALTALMGCSPWLLYVFCFVFFHTTWASILLVLQLYQIAFLGLTTSERANLM 582

Human   560 KQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTM 609
            .:.:.:.|.:|||:.|:|.|.::||.:|||....||.||.|:|||.|:.|
Zfish   583 HRQRKLPQAVSLRQNPFNHGVVKNLVNFFQWRFCGLCKPMVLDWTQQHPM 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78		26/34 (76%)
		ANK	79..192	CDD:238125	86/112 (77%)
		ANK repeat	81..112	CDD:293786	25/30 (83%)
		ANK 2. /evidence=ECO:0000255	81..110		23/28 (82%)
		ANK repeat	114..146	CDD:293786	25/31 (81%)
		ANK 3. /evidence=ECO:0000255	115..144		23/28 (82%)
		ANKYR	<145..271	CDD:223738	77/128 (60%)
		ANK repeat	148..179	CDD:293786	19/30 (63%)
		ANK 4. /evidence=ECO:0000255	148..177		19/28 (68%)
		ANK repeat	181..247	CDD:293786	43/65 (66%)
		ANK 5. /evidence=ECO:0000255	181..211		21/29 (72%)
		ANK 6. /evidence=ECO:0000255	216..245		17/28 (61%)
		ANK 7. /evidence=ECO:0000255	249..277		13/30 (43%)
		zf-DHHC	423..559	CDD:307600	65/135 (48%)
zdhhc13	NP_001008650.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73		17/69 (25%)
		ANKYR	<62..204	CDD:223738	105/143 (73%)
		ANK repeat	76..102	CDD:293786	21/25 (84%)
		ANK repeat	104..135	CDD:293786	25/30 (83%)
		ANK 1. /evidence=ECO:0000255	104..133		23/28 (82%)
		PHA03095	115..>312	CDD:222980	126/199 (63%)
		ANK repeat	137..169	CDD:293786	25/31 (81%)
		ANK 2. /evidence=ECO:0000255	138..167		23/28 (82%)
		ANK 3. /evidence=ECO:0000255	171..200		19/28 (68%)
		ANK repeat	176..202	CDD:293786	17/25 (68%)
		ANK repeat	204..236	CDD:293786	22/31 (71%)
		ANK 4. /evidence=ECO:0000255	204..234		21/29 (72%)
		ANK repeat	239..270	CDD:293786	18/30 (60%)
		ANK 5. /evidence=ECO:0000255	239..268		17/28 (61%)
		DHHC	450..580	CDD:396215	63/129 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194334759
Domainoid	1	1.000	109	1.000	Domainoid score	I24362
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75106
Inparanoid	1	1.050	636	1.000	Inparanoid score	I4899
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54696
OrthoDB	1	1.010	-	-		D117873at7742
OrthoFinder	1	1.000	-	-		FOG0001761
OrthoInspector	1	1.000	-	-		oto49627
orthoMCL	1	0.900	-	-		OOG6_101007
Panther	1	1.100	-	-	LDO	PTHR24161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X628
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.410