DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC13 and CG17197

DIOPT Version :9

Sequence 1:	NP_061901.2	Gene:	ZDHHC13 / 54503	HGNCID:	18413	Length:	622	Species:	Homo sapiens
Sequence 2:	NP_651425.2	Gene:	CG17197 / 43111	FlyBaseID:	FBgn0039367	Length:	290	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	64/280 - (22%)
Similarity:	111/280 - (39%)	Gaps:	72/280 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   329 FLTSLFPRFLVGYKNLVYLPTAFL---LSSVFWIFMTWFI----LFFPDLAGAPFYFSFIFSIVA 386
            :|....|:..|...:    |||.|   ::::|::.:..|.    ||  |:.|..:...::.:|..
  Fly    10 YLARRNPKIFVRISH----PTAVLFVIVTTIFFVVLQMFYVVPQLF--DVQGFMYKLGWLVAIFI 68

Human   387 FLYFFYKTWATDPGFTKAS-----------EEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSL 440
            ....|....|.....|...           |||.:.:              :|..|....|.||.
  Fly    69 TYNIFGNMLACHITSTSVESLPKDRQIPEPEEEHQWH--------------YCDVCEKLMPPRSW 119

Human   441 HCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDG 505
            ||.:|.||:.:.|:||::|..|:|..|..|:.:|..|:::       |:.:.|::|...|.|
  Fly   120 HCILCKCCILKRDRHCIFTASCVGHNNQRYFFWFTLFMAL-------GTGVALATHIIATLK--- 174

Human   506 LWTYLNQIVACSP-------WVLYILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSK 563
            .::|.:.|....|       |::..|:|.|:.|:.....:|.||..:...| |.|:..|
  Fly   175 YFSYSDLIFLNIPRDNLPPFWLVITLILNTYVFAAPVSSVLMQLSVLKNNG-TLHKFYS------ 232

Human   564 HMKQTLSLRKTPYNLGFMQN 583
                      ..|:||..:|
  Fly   233 ----------DTYDLGLWEN 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC13	NP_061901.2	ANK 1. /evidence=ECO:0000250\|UniProtKB:Q8IUH5	43..78
		ANK	79..192	CDD:238125
		ANK repeat	81..112	CDD:293786
		ANK 2. /evidence=ECO:0000255	81..110
		ANK repeat	114..146	CDD:293786
		ANK 3. /evidence=ECO:0000255	115..144
		ANKYR	<145..271	CDD:223738
		ANK repeat	148..179	CDD:293786
		ANK 4. /evidence=ECO:0000255	148..177
		ANK repeat	181..247	CDD:293786
		ANK 5. /evidence=ECO:0000255	181..211
		ANK 6. /evidence=ECO:0000255	216..245
		ANK 7. /evidence=ECO:0000255	249..277
		zf-DHHC	423..559	CDD:307600	40/142 (28%)
CG17197	NP_651425.2	PHA02688	<9..70	CDD:222919	14/65 (22%)
CG17197	NP_651425.2	zf-DHHC	100..>198	CDD:279823	31/121 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S11709
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760