DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM47 and rbm47

DIOPT Version :9

Sequence 1:	NP_001092104.1	Gene:	RBM47 / 54502	HGNCID:	30358	Length:	593	Species:	Homo sapiens
Sequence 2:	XP_005168416.1	Gene:	rbm47 / 562991	ZFINID:	ZDB-GENE-030131-9612	Length:	601	Species:	Danio rerio

Alignment Length:	612	Identity:	473/612 - (77%)
Similarity:	528/612 - (86%)	Gaps:	30/612 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTAEDSTA--AMSSDSAAGSS----------AKVPEGVAGAPNEAALLALMERTGYSMVQENGQR 53
            ||||||.:  |||:.|.:.||          ..||||||||||||||::||||:||.||||||||
Zfish     1 MTAEDSASAVAMSNPSPSSSSKSSSGHPQHHCTVPEGVAGAPNEAALVSLMERSGYGMVQENGQR 65

Human    54 KYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMY 118
            || ||||||:|..|.||||:|||||||||||||||||||:||||||:||||||||||||||||||
Zfish    66 KY-GPPPGWQGTSPPRGCEIFVGKIPRDVYEDELVPVFESVGRIYEMRLMMDFDGKNRGYAFVMY 129

Human   119 CHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIV 183
            ..|||||||||||||:|||||||||||.||||||||||||||.|||||||||::|||||||||||
Zfish   130 TQKHEAKRAVRELNNFEIRPGRLLGVCSSVDNCRLFIGGIPKTKKREEILEEVSKVTEGVLDVIV 194

Human   184 YASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKIL 248
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   195 YASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKIL 259

Human   249 YVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEV 313
            |||||||||:|:.::::|||||||||||||||||||||||.||:|||.||:||||||:|||.:||
Zfish   260 YVRNLMIETSEEILRQTFGQFNPGCVERVKKIRDYAFVHFASRDDAVVAMDNLNGTEIEGSRIEV 324

Human   314 TLAKPVDKEQYSRYQKAARGGGAA---EAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKA 375
            |||||||||||:|||||::|..||   |:.|| ||||.||||||||||||||.|||||||||:||
Zfish   325 TLAKPVDKEQYTRYQKASKGTAAATTVESTQQ-SYVYQCDPYTLAYYGYPYNTLIGPNRDYFIKA 388

Human   376 GSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEIPTVNPVAIK 440
            |::|||||..|.:|.|||||||||||||||||||||||||.|..:|.||::.|||:..||||.||
Zfish   389 GTVRGRGRAGASSRGPGPRGSYLGGYSAGRGIYSRYHEGKTKLPDKPYEIMSNLELAAVNPVGIK 453

Human   441 PGTVAIPAIGAQY-SMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVI 504
            |||:|:||:|||| ::|.||||.|::|:||||.|||:|:|:|:|.||        .||:|.||||
Zfish   454 PGTMALPALGAQYPTVFSAAPATKLMEEGKIHPVEHLINPLALQHDP--------TAASATAAVI 510

Human   505 PTVSTPPPFQGRPITPVYTVAPNVQRIP--TAGIYGASYVPFAAPA-TATIATLQKNAAAAAAMY 566
            |.||||||||||||||||.:|.|:||||  .|.:|||.|:|.||.| |||:|.||||||.||| |
Zfish   511 PAVSTPPPFQGRPITPVYAMAHNIQRIPAAAASLYGAGYMPIAAHANTATLAALQKNAAVAAA-Y 574

Human   567 GGYAGYIPQAFPAAAIQVPIPDVYQTY 593
            ||||||:|||||||..|:||.||||||
Zfish   575 GGYAGYMPQAFPAATFQMPIHDVYQTY 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM47	NP_001092104.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		14/35 (40%)
RBM47	NP_001092104.1	hnRNP-R-Q	21..593	CDD:273732	459/578 (79%)
rbm47	XP_005168416.1	hnRNP-R-Q	34..601	CDD:273732	459/577 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338669
Domainoid	1	1.000	396	1.000	Domainoid score	I4709
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H36932
Inparanoid	1	1.050	930	1.000	Inparanoid score	I2659
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43401
OrthoDB	1	1.010	-	-		D1384330at2759
OrthoFinder	1	1.000	-	-		FOG0000581
OrthoInspector	1	1.000	-	-		oto41981
orthoMCL	1	0.900	-	-		OOG6_105311
Panther	1	1.100	-	-	LDO	PTHR21245
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X331
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.410