DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATR and tefu

DIOPT Version :10

Sequence 1:XP_011511226.1 Gene:ATR / 545 HGNCID:882 Length:2646 Species:Homo sapiens
Sequence 2:NP_001036712.1 Gene:tefu / 41839 FlyBaseID:FBgn0045035 Length:2767 Species:Drosophila melanogaster


Alignment Length:3195 Identity:625/3195 - (19%)
Similarity:1074/3195 - (33%) Gaps:1136/3195 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    32 KPRQILCQFIDRILTDVNVVAVELVKKTDSQPTSVMLLDFIQHIMKSSPLMFVNVSGSHEAKGSC 96
            |.|.::..|.||||:       .|.|...|..:.|..|...::....|.|..:||          
  Fly   129 KMRVVVKYFGDRILS-------LLEKGIYSSVSYVRDLKINEYSRILSYLFELNV---------- 176

Human    97 IEFSNWIITRLLR-IAATPSCH----LLHKKICEVICSLLFLFKSKSPAIFGVLTKELLQLF--- 153
             :....:.||:|: |..|.|..    .||..:.|.:..|    .|.:.:.||....|:::::   
  Fly   177 -DMDEVLRTRILKCITRTVSLAKDRVQLHVDLVEYLPEL----SSFALSAFGARKTEIVRVYLIF 236

Human   154 -EDLV--YLHRRNVMGHAVEWPVVMSRFLSQLDE-------------------HMGYLQSAPLQL 196
             .:|.  |.|:.||  |..|   ::.:.....||                   |..||:      
  Fly   237 ASELAVNYNHQLNV--HMQE---ILPKLCEYHDEDAFRDDTRNLFFQCVSKSLHSMYLK------ 290

Human   197 MSMQNLEFIEV--------TLLMVLTRIIAIVFFRRQELLLWQIGC--VLL---EYGSPKIKSLA 248
            |.|.:...:.|        |||.:.|  |..|..|:..   | ..|  .||   ::..|.||..|
  Fly   291 MDMCDFNTLGVPVHEKWPQTLLRLKT--IVNVEIRKNS---W-ARCKNALLSNNKFSDPFIKMSA 349

Human   249 ISFLTELFQLGGLPAQPASTFFSSFLELLKHLVEMDTDQLKLYEEPLSKLIKTLFPFEAEAYRNI 313
            ::....|:.                ||..|.....:.|..|...:|..|: :|:|....:.....
  Fly   350 LAMYIVLWH----------------LETKKADENGEGDAPKKIPKPADKM-ETIFSLIDKKENTF 397

Human   314 EPVYLNMLLEKLCVMFEDGVLMRLKSDLLKAALCHLLQYFLKFVPAGYESAL----QVRKVY--- 371
            ..|:|.:..|          :::|.|.:|..              |.|:.||    ::.::|   
  Fly   398 NDVWLAIFTE----------ILQLSSVILNV--------------ANYQMALTTVAEIMQMYGNA 438

Human   372 --VRNICKALLDVLGIEVD-------AEYLLGPLYAALKMESMEIIEEIQCQTQQENLSSNSDGI 427
              :||:...|..:|..|.:       .|..||.|::.:   :.::|.|         .::||:.|
  Fly   439 KNLRNLRLCLAHLLTKEQELLHSKSIREDFLGELWSQM---ANQLISE---------TTTNSEEI 491

Human   428 SPKRRRLSSSLNPSKRAPKQTEEIKHVDMNQKSILWSALKQKAESLQISLEYSGLKNPVIEMLEG 492
            ..|:..|...             |:|..:|||             |..:|..:.:.|.:::..|.
  Fly   492 KEKQLVLQML-------------IRHNKLNQK-------------LSSTLLNNIISNEMLKRNEC 530

Human   493 IAVVLQLTALCTVHCSHQNMNCRTFKDCQHKSKKKPSVVITWM--SLDFYTKVLKSCRSLLESVQ 555
            :|.:.::    .:|..         |..|.|:......:|.|.  |.|.:.     ...::.::.
  Fly   531 LATIREI----FIHAD---------KCGQDKASADLEPIIAWAYGSADRFI-----AAQMIHNID 577

Human   556 KLDLEATID----KVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAAN 616
            .:|.:...|    .::...|.....|::.|  :||                       :.:...|
  Fly   578 SIDAQLQADTFAISIINFLDVQQLRQISQS--EHI-----------------------VPSTERN 617

Human   617 LLTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQ 681
            ||        :|....|..|.......|.......::...|..:||:::.:    :.|....:.:
  Fly   618 LL--------AYKYNEQLICFDKDYATPFESITHIQSETKNCLIQSNYDCL----MRGLNFEIAK 670

Human   682 QNSCNRVPKILIDKVKDDSDIVKKEFASILGQLVCT----LHGMFYLTSSLTE-PFSEHGHVDLF 741
            :|.    |..:|           |...|:| :|:||    ||...:...:.|. |..:  .:.|:
  Fly   671 ENK----PAAII-----------KNLNSLL-KLICTMERLLHYKVFDADTYTGCPLIK--RIGLY 717

Human   742 CRNLKATSQHECSSSQLKASVCKPFLFLLKKKIPSPVKL------AFIDNLHHLCKHLDFREDET 800
            ..:::         .||||:..:   .|.|..:|..::|      .|..||              
  Fly   718 LSHIE---------FQLKANGAE---ILDKSDLPEILRLEIYVLDVFRTNL-------------- 756

Human   801 DVKAVLGTLLNLMEDPDKDVRVAFSG-NIK-HILE---SLDSEDGFIKEL----------FVLRM 850
                   .||:.:|....::.|.|.| .:| |.::   |:|::.|.|..|          :....
  Fly   757 -------VLLDYLERQPIEMLVEFVGAALKLHSMQRERSVDADHGTITRLCLNILAGLCAYNSHR 814

Human   851 KEAYTH-AQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAAYTEIRAL 914
            .||:.| .:::.....:|.||:|.                 .|..|.....||.|.        |
  Fly   815 DEAFEHIVKVTMRWHPQDVLIVTK-----------------MLCSCQTISEASSSW--------L 854

Human   915 VAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAH---------QRE- 969
            |:    ||::.|.|:.                        |:|::..:.|.|         .:| 
  Fly   855 VS----KLKTLFQQHH------------------------QDAELMDKVVQHMPTIFYFVRHKEN 891

Human   970 ------MALNTLSEIANVFDFPDLNRFLTRTLQ---VLLPDLAAKASPAA------SALIRTLGK 1019
                  ||||:|..||       :.:..|..|.   |....|.|:..|..      :.:.::..|
  Fly   892 HLDDMLMALNSLLRIA-------IKKSYTSNLTAKIVRCVGLIAQRCPDIYLLENFAVICKSTAK 949

Human  1020 QLNVNRREILINNFKYIFSHLV-----CSCSK------------DELERALHYLK----NETEIE 1063
            .:.:...|:   .|..:|:..:     |..|.            .||..::.:.|    ||..|:
  Fly   950 FITMPTLEV---RFATLFTFTILLESNCVTSDAIGHSRTHWDFCQELYESIEFKKLTYNNEDAIQ 1011

Human  1064 ----------LGSLLRQDFQGLHNELLLRIGEHY-------QQVFNGLSILASFASSDDPYQGPR 1111
                      :...||..|   |.|:.|:...|:       ::.|..|..::|...     |..|
  Fly  1012 NSNALIVQMLIAIFLRSSF---HQEIALKELLHHCALRRLTEREFISLQSMSSCHR-----QTVR 1068

Human  1112 DIISP-------------------------------------ELMA-DYLQPK------------ 1126
            |:|.|                                     |:|| .:|..|            
  Fly  1069 DLIRPFAAILLHHWSSKRWPISKFPYFLCYSTKSEFRKTHASEIMAYTFLYGKTEDIERCSKSIS 1133

Human  1127 ---LLGILAFF------------------NMQLLS-----SSVGIEDKKMALNSLMSLMKLMGPK 1165
               .|.|||.|                  ::||||     |.:...|..:.|:.|..::.::   
  Fly  1134 EELALPILASFLLIKNSSCSESEGQNFKEHLQLLSENLSYSQLNATDVDLDLDILCYVISML--- 1195

Human  1166 HVSSVRVKMMTTLRTGLRFKDDFPELCCR--AW-----DCFVRCLDHACLGSLLSHVIVALLPLI 1223
            |.....:::..:|           .:|.|  :|     :...:||:.        |:...:.|.:
  Fly  1196 HDPQEMMRLFGSL-----------AICNRTASWYSLSGESLFKCLNF--------HIDPEMRPSM 1241

Human  1224 --HIQPKETAAIFH----------------------------YLIIENRDAVQD----------- 1247
              .||...|....|                            :|..|..|||.|           
  Fly  1242 DSRIQSMTTLQTKHSRVLVDIFGRLKTNCYSASFSSQALHDFFLYCEVADAVYDAARKNETIVTQ 1306

Human  1248 ---FLHEIYF----LPDHPELKKIKAV---------------LQEYRKETSESTDLQTTLQL--S 1288
               |:.:|:|    |..|.:..:::..               |.:|:....:...|.:..||  .
  Fly  1307 CSFFVRDIWFFVVRLLIHTKFIRVQMAALTFLELLLNKHNFRLDDYQNHFGDIAKLLSNFQLCCE 1371

Human  1289 MKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSETVEPI---------------------- 1331
            .|.::.:.:.:.::.|.|.|..:  |....::..||.|.::|:                      
  Fly  1372 AKEVREKTMSIVMYILESKKGHI--NLNSFLEETTDCEFLKPLREDCKSSQPNIDRADVANYLRS 1434

Human  1332 ---------ISQLVTVLLKGCQDANSQARLLCG----------------------ECLGELGAID 1365
                     :..|.|.:.:.........:||.|                      :||.::|.  
  Fly  1435 FLLSPTPERLRDLRTYIAEHKDKVQEHEKLLFGVINKLIQMTRDAHNKTTSIDSLKCLAQIGP-- 1497

Human  1366 PGRLDFSTTETQGKDFTFVIETGVEDSSFAYGLLMELTRAYLAYADNSRAQDSAAYAI-----QE 1425
               |..||.       ::..:|..|....:.|..||   |:|....:|  .|::.:..     :.
  Fly  1498 ---LKISTV-------SYYFQTDFEAFEKSNGEPME---AFLGVVCHS--LDTSLFQFDPKTHEG 1547

Human  1426 LLSIYDCREMETNGPGHQLWRRFPEHVREILEPHLNTRYKSSQKS---TDWSGVKKPIYLSKLGS 1487
            |:|:  ..::..:.||..:..|: :::|...:....:.:..|.|.   .||..:.|    :....
  Fly  1548 LVSV--AIQVVNSKPGSNIMERY-KNLRIFADKSTASTFLHSNKQIRRIDWLSILK----ATKSL 1605

Human  1488 NFAEWSASWAGYLITKVRHDLASKIFTCCSIMMKHDFKVTIY------LLPHILVYVLLGCNQED 1546
            ::..|..::            .||:|..|..:.......|.:      |||.|.:          
  Fly  1606 SYEPWMCAF------------VSKVFQMCGWLGFDKLAATSFAFAKTCLLPFIKL---------- 1648

Human  1547 QQEVYAEIMAVLKHDDQHTINTQDIASDLCQLSTQTVFSMLDHLTQWARHKFQALKAEKCPHSKS 1611
                      :|::..:|               .:::..|||:.       |:...:...|:|:.
  Fly  1649 ----------LLENSLEH---------------VESLSQMLDYF-------FEGFTSSTAPNSQE 1681

Human  1612 -NRNKVDSMVSTVDYEDYQSVTRFLDL-------------IPQDTLAVASFRSKAYTRAVMHFES 1662
             .|||             :::.:||.:             |....:.:||...:||..::|:.| 
  Fly  1682 IFRNK-------------RAIKKFLHICEYIRIFNNWTIPINLSNVVMASNHCQAYFLSIMYLE- 1732

Human  1663 FITEKKQNIQEHLGFLQKLYAAMHEP-------DGVAGVSAIRKAEPSLKEQILEHESLGLLRDA 1720
                              |:|....|       |........:||          :||:|.| ||
  Fly  1733 ------------------LWACSESPKSKADFLDNECFQDGAKKA----------YESIGCL-DA 1768

Human  1721 TACYDRAIQLEPDQIIHYHGVVKSML-------GLGQLSTVITQVNGVHANRSEWT-DELNTYR- 1776
            ...:...::...|.:.|...:...:|       ..|||...|.:.||:      |: .:|..:: 
  Fly  1769 IPGFVNPMRSRLDFLGHGSNLSTILLESDHLDRASGQLCIDIMKGNGL------WSFAKLQQHQN 1827

Human  1777 ----VEAAWKLSQWDLVENYLAADGKSTTWS-------------VRLGQLLLSAKKRDITAFYDS 1824
                .|..|:|.|||.:.:......::...:             |.|..:....::..::|...:
  Fly  1828 IEPDYEIFWRLGQWDSLTDPKHQQNQTVVRTSLDLEQEFKRHHFVALRSIGQREEENSLSAIEQA 1892

Human  1825 LKLVRAEQIVPLSAASFERGSYQRGYEYIVRLHMLCELEHSIKPLF--QHSPGDSSQEDSLNWVA 1887
            ...|| :.::.:|....     |..|:|:..|..|.:.|...:..|  |..|. |:.:....|..
  Fly  1893 YSCVR-DILMEISVECL-----QSVYKYLTWLCSLQQAEDFCQIQFGTQLDPA-STTKIFRKWQT 1950

Human  1888 RLEMTQNSYRAKEPILALRRALLSL-------------NKRPDYNEM---VGECWLQSARVARKA 1936
            .||:...::..||.::|.:.|||.|             .|.|....:   :.||  :||.....|
  Fly  1951 ELELKYGNFSCKEYVIAHQIALLKLAGTRASRRMSEFYQKDPISTYLMKGIEEC--KSAGKLNLA 2013

Human  1937 GHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQ---KGVELCFPENETPPEGKNM 1998
            ..:......|.|..||....:.:|.|:.....|:...|..:|.   ...|..:.....|      
  Fly  2014 AKYTATLRELPNIRESIKISVLLEDAEINLKMGNQQIAKAILDYVTNNNEFVYCVQRVP------ 2072

Human  1999 LIHGRAMLLVGRFM----EETANF------------------ESNAIMKKYKDVTACLPEWEDGH 2041
                 |:.:.|.|:    .||.::                  ....:.:||:|:.    :|....
  Fly  2073 -----ALRMQGEFLLDCNAETLSWVQSHKFNNSLKLIDDFVQHRQTLSEKYRDIF----DWHQLD 2128

Human  2042 FY-----------LAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTL 2095
            .|           :|||.|:                 .|..||     .|.:...||::..::..
  Fly  2129 AYASKQRTAAYATIAKYADR-----------------EYQQLH-----DYRHSQEYQTLKDIIEQ 2171

Human  2096 WLDYGTKAYEWEKAGRSDR----VQMR-------NDLGKINKVITEH-----TNYLAPYQFLTAF 2144
            ......|..:.|   ..||    |||:       ..|.:|.:.:||:     |||:|..:..:.|
  Fly  2172 NRQTAEKVTQRE---NQDRRVISVQMKRYASLDEQQLNQIEEKLTEYLRLALTNYMAYCRLDSGF 2233

Human  2145 SQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKKS 2209
            |.             ..:..||          ::|...|.||        :|:|.:...|....|
  Fly  2234 SS-------------AAIYRII----------SLWFTNATSK--------QCQECIKDEILTVPS 2267

Human  2210 LEKFVGDATRLTDK--------------LLELCNKP----------------VDGSSSTLSMSTH 2244
            . ||:..|.:||.:              ||..|.|.                :||.:|....|  
  Fly  2268 Y-KFICAANQLTARLNSKNTSLLKGLTDLLVQCGKDHPYHTFYQLYPLVFAHLDGENSNTERS-- 2329

Human  2245 FKMLKKLV-----EEATFSEILIPLQSVMIPTLPSILGTHAN----------------------- 2281
             .:.:|::     :..|..|....|:|:    ||::: |.||                       
  Fly  2330 -GIARKIIAMICEKNGTAGECSKQLESL----LPALI-TFANEGKTNDNRPVSDSVRNKQFDKVR 2388

Human  2282 -----HASHEP------FPGHWAY----IAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPK 2331
                 :|.|.|      .|.. .|    :..:.:.......|..|.||....||||....:.|.|
  Fly  2389 RWRNLNAVHCPTLELPVMPSK-EYSIISVVKWTNETTQCGGLNAPVKIMCVCSDGKIRAQLVKGK 2452

Human  2332 DDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPIL---- 2392
            ||||:|..:.:...::|:.|.:|:|...|:|.:|||.|.||:...||:||..|:..:...|    
  Fly  2453 DDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYKVTPLSMRSGILEWCTNSVPVGHYLVVEG 2517

Human  2393 ---------------TKLYKEKGVYM-TGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEW 2441
                           .|..|....:: :.||.|..:..|   :.|.:|           |:||.:
  Fly  2518 KGGAHARYRPNDWNNNKCRKLSSDHLKSPKETRYAIYKK---ICENIK-----------PVFHYF 2568

Human  2442 FLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGET 2506
            .|..||.|..|:..|.||..|.|..|||||:|||||||.:|||.|..|.|.:|:||...|.:|:.
  Fly  2569 LLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGLGDRHTQNILVDQQTAEVIHIDFGIAFEQGKI 2633

Human  2507 FEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPV 2571
            ...||.||||||.:.|..||..||:|:|.::||.||.::|..:....::|:..|:|||..|.  |
  Fly  2634 QTTPETVPFRLTRDFVAPMGICGTKGVFAKSCEATMHILRRYKSVFTTILEVLLYDPLFIWG--V 2696

Human  2572 KGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLC 2636
            ....::|.....|.||..|:..:|.::.:|.|    |...|....::|..|..||.|||..:.||
  Fly  2697 LKKKQSPQQSGEESVNLVAQRALLLVQNKLDG----REAGTMGDSNVEAQVERLINEATLPSNLC 2757

Human  2637 QMYLGWTPYM 2646
            .::.||.|::
  Fly  2758 MLFPGWDPHL 2767

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATRXP_011511226.1 UME 1119..1224 CDD:214825 26/152 (17%)
FAT 1773..2094 CDD:396714 70/392 (18%)
TEL1 <2135..2646 CDD:227365 167/603 (28%)
PIKKc_ATR 2295..2569 CDD:270625 103/293 (35%)
tefuNP_001036712.1 FAT 1829..>2064 CDD:396714 48/243 (20%)
PIKKc_ATM 2416..2696 CDD:270715 103/295 (35%)
FATC 2739..2767 CDD:460514 12/27 (44%)

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