Protein Alignment ATR and rad3

DIOPT Version :9

• Sequence 1: XP_011511226.1
• Gene: ATR / 545
• HGNCID: 882
• Length: 2646
• Species: Homo sapiens
• Sequence 2: NP_595357.1
• Gene: rad3 / 2540719
• PomBaseID: SPBC216.05
• Length: 2386
• Species: Schizosaccharomyces pombe
• Alignment Length: 2572
• Identity: 673/2572 - (26%)
• Similarity: 1127/2572 - (43%)
• Gaps: 520/2572 - (20%)

Human   379 LLDVLGIEVDAEYLLGPLYA--ALKMESMEIIEEIQCQTQQENLSSNSDGISPKRRR-----LSS 436
            |.:||.:  |.|:.||...:  ::..|.:|::.|:.....:.: .|.|:.||||..:     |.:
pombe    29 LKEVLAL--DKEHELGRSNSLPSMTSELVEVLIEVGLLAFKHD-DSKSEFISPKMLKEAHLSLQA 90

Human   437 SLNPSKRAPKQTEEIKH----VD--------------------------------MNQKSILWSA 465
            .:...||:|....|||.    :|                                :::||.||..
pombe    91 LMLILKRSPTVLREIKSSVTLLDWILPRTISLFADIRFIKLFDSLKEFHKLIYQLISEKSFLWDL 155

Human   466 LKQ------------KAESLQI---SLEYSGLKNPVIEMLEGIA-------------VVLQLTAL 502
            ...            .:..|||   :..|. :.:|..:.|:.|.             :::.:...
pombe   156 YASFMRYWKYYITNVSSIVLQITNATFPYK-MPSPNSQPLQSITPNYPTHREDKFDLLIINIEEA 219

Human   503 CTVHCSHQNMNCRTFKDCQHKSKKK-PSVVI----TWMSLDFYTKVLKSCRSLLESVQKLDLEAT 562
            ||....    :...|..|.:..|.. ||..:    ||:...|:..|:     ||
pombe   220 CTFFFE----SAHFFAQCSYLKKSNFPSPPLFTAWTWIKPCFFNFVI-----LL----------- 264

Human   563 IDKVVKIYDALIYMQVNSSFEDHILEDLCGMLSLPWIYSHSDDGCLKLTTFAANLLTLSC-RISD 626
              |.:.|.|:.:::.::|    .|::.|| ..||.:|| |....|.|......:.:.|:. .:..
pombe   265 --KRISIGDSQLFLHLHS----RIVQTLC-CFSLNFIY-HGLPICEKSKHILMSSINLTLGSLKK 321

Human   627 SYSPQAQSRCVFLLTLF--PRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFILLQQQNSCNRVP 689
            :|:....:..:|.|:||  |:.:    ....|.:.:         |.:|.|.:|.|.:...:...
pombe   322 TYTVANTAISLFFLSLFVLPKTV----AGLFYPFGV---------SLLSDFKVLEQLEPDSDLKK 373

Human   690 KILIDKVK--------------------------------------------DDSDIVKKEFASI 710
            .|::.|.:                                            |.|:|:|.:|.:
pombe   374 AIILFKCRYQSSEIDQTTLRAFGEICTGKLENTLFSNSELNLFLLHYLSLDNDLSNILKVDFQN- 437

Human   711 LGQLVCTLHGMFYLTSSLTEP------------FSEH----GHVDL------FCRNLKATSQ--- 750
             |..:||. ..:.:.::|.||            :|.|    ...||      .|.::...::
pombe   438 -GHNICTF-AKWCINNNLDEPSNLKHFREMLDYYSSHNVTISEDDLKNFSLVLCTHVAKVNEKTN 500

Human   751 --------HECSSSQLKASVCKPFLFLLKK----KIP----------------SPVKLA-FIDNL 786
                    |.|       .||..|..|..:    |||                |.||.: .:|..
pombe   501 SIFRTYEVHGC-------EVCNSFCLLFDERSLFKIPYHELFCALLKNPDIISSSVKQSLLLDGF 558

Human   787 HHLCKHL-DFRED------ETDVKAVLGTLLNLMEDPDKDVRVAFSG--NIKHILESLDSEDGFI 842
            ....:|. :|.::      |..:||:..|...|.....|.:.:...|  |:..:....:|:....
pombe   559 FRWSQHCSNFNKESMLSLREFIMKALASTSRCLRVVAAKVLPIFIKGPNNLDIVEFHKESKALIF 623

Human   843 KELFVLRMKEAYTHAQISRNNELKDTLILTTGDIGRAAKGDLVPFALLHLLHCLLSKSASVSGAA 907
            ..|.:|.::          |..:.:|:||:...:.|..:.:.:.|.||.::..:::......|..
pombe   624 NTLKILAVE----------NTAILETVILSWISLSRVVEEEELHFVLLEVISSVINSGIFYQGIG 678

Human   908 YTEIRALVAAKSVKLQSFFSQYKKPICQFLVESLHSSQMTALPNTPCQNADVRKQDVAHQREMAL 972
            .:.::.:.:.:.:.:....|.|...:...:|:.:.                 :|.::|
pombe   679 LSALQQIASTRHISVWQLLSPYWPTVSVAIVQGMG-----------------KKPNIA------- 719

Human   973 NTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREILINNFKYIF 1037
            :..:::.|:.:    ..||.||....||.|....:   .|||..:.:....:...:.:.|...|.
pombe   720 SLFAQLMNISE----GDFLIRTQAYTLPFLVLTKN---KALIVRIAELSQSDVATLCLTNMHKIL 777

Human  1038 SHLVCSCSKDELERALHYLKNET----EIELGSLLRQDFQGLHNELLLRIGEHYQ------QVFN 1092
            :.|:.:...:..|..:..|...|    :::|.||||.|...:..|||    :.||      ::.|
pombe   778 ASLLTTDHPNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVELL----QLYQNDVPHEKIEN 838

Human  1093 GLSILASFAS---SDDPYQGPRDIISPELMADYLQPKLLGILAFFNMQL--LSSSVGIEDKKMAL 1152
            .|..:|...|   :|:      |:.:.||:.|:....:|||||.|:..|  |.....|.:|...:
pombe   839 ALRKVAMIVSQVVNDE------DLSNKELLYDFFNNHILGILAEFSNILNDLKGKTSINEKIKTI 897

Human  1153 NSLMSLMKLMGPKHVSSVRV---KMMTTLRTG-----LRFKDDFPELCCRAWDCFVRCLDHACLG 1209
            ..:..::.|.|    .:|::   ::::.|::.     |||      ...:||...:.........
pombe   898 VGIEKMLSLCG----GAVKLGLPQILSNLQSAFQNEHLRF------YAIKAWFSLILATKEPEYS 952

Human  1210 SLLSHVIVALLPLI-HIQPKETAAIFHYLIIENRDAVQDFLHEI-----YFLPDHPE-------L 1261
            |:....:|.|.||. :::|:|..     |:|:..|.:....|:.     :.:|...:       .
pombe   953 SIAGLSLVILPPLFPYLEPQEAE-----LVIQIFDFISSDTHKCLQGLKWAIPTSLDSACFSLKA 1012

Human  1262 KKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLIKYATDSE 1326
            |:|...||        :.|..:.||..:|.:.:||..|....|..| |..::.:...:....:.:
pombe  1013 KEIFCSLQ--------NEDFYSELQSIIKCLTNENEPVCYLGLQKL-ELFFQAKVDELHDTLNLD 1068

Human  1327 TVEPIISQLVTVLLKGC---QDANSQARLLCGECLGELGAIDPGR--LDFSTTETQGKDFTFVIE 1386
            ....::.||:..||..|   ...|.|...|..:.|||||||||.|  ......||...|   ..|
pombe  1069 ISNEVLDQLLRCLLDCCVKYASTNMQISYLAAKNLGELGAIDPSRAKAQHIIKETVVLD---NFE 1130

Human  1387 TGVEDSSFAYGLLM-ELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMETNGPG-----HQLW 1445
            .|.|...|....:. :|..|:|...| ::||...|||:||.|.:...:....|...     .:.|
pombe  1131 NGEESLKFILDFMQSQLIPAFLVTTD-TKAQGFLAYALQEFLKLGGFKSAVINKKKGLTVVTEHW 1194

Human  1446 RRFPEHVREILEPHLNTRYKSSQ-KSTDWSGVKKPIYLSKLGSNFAEWSASWAGYLITKVRHDLA 1509
            ...|:..:.:|.|.|.::|..:. ...|   ::.|||  |.......|...::..|:.......|
pombe  1195 MSLPDLSKRVLIPFLTSKYHLTPIPKID---IRYPIY--KENVTIHTWMQLFSLKLMEYAHSQNA 1254

Human  1510 SKIFTCCSIMMK-HDFKVTIYLLPHILVYVLLGCNQEDQQEVYAEIMAVLKH---DDQHTINTQD 1570
            .|||..||.::| .:..:..:|||.:::.|:|..::.:..:|..|...|:..   |..:::..|.
pombe  1255 EKIFGICSKVVKDQEVNIPCFLLPFLVLNVILTESELEVNKVIEEFQLVINQPGPDGLNSVGQQR 1319

Human  1571 IASDLCQLSTQTVFSMLDHLTQW---------------ARHKFQALKAEKCPHSKSNRNKVDSMV 1620
            ..|     .....|.::|:|.:|               ||.:.:.:..|.....:|:.:||:|
pombe  1320 YTS-----FVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVES-- 1377

Human  1621 STVDYEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFI---TEKKQNIQEHLGFLQKLY 1682
                         ||...|..||.:.|.....:.||:.::|..|   |.....::.....||::|
pombe  1378 -------------FLSRFPSKTLGIVSLNCGFHARALFYWEQHIRNATAPYAALESDYRVLQEIY 1429

Human  1683 AAMHEPDGVAGVSAIRKAEPSLKEQILEHESLGLLRDATACYDRAIQLEPDQIIHYHGVVKSMLG 1747
            |.:.:||.:..|| :...:.|..:|:|.||:.|....|.:||:..||.:|:......|::.|||.
pombe  1430 AGIDDPDEIEAVS-LNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNSMLQ 1493

Human  1748 LGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVENYLAADGKST--TWSVRLGQLL 1810
            .|...:::..::....|.:....::....:||:|:....|.::..|:   ||.  ::..:||.:.
pombe  1494 SGHYESLVLSLDSFIINDNHEYSKMLNLGIEASWRSLSIDSLKKCLS---KSNLESFEAKLGSIF 1555

Human  1811 LSAKKRDITAFYDSLKLVRAEQIVPL----SAASFERGSYQR--GYEYIVRLHMLCELEHSIKPL 1869
            ....::|..|       ...|::.||    :.|....|::..  .|:.:.:|       |:|...
pombe  1556 YQYLRKDSFA-------ELTERLQPLYVDAATAIANTGAHSAYDCYDILSKL-------HAINDF 1606

Human  1870 FQHSPGDSSQEDSLNWVARLEMTQNSYRAKEPILALRRALLSLN----KRPDYNEMVGECWLQSA 1930
            .:.:..|....|:|:.|.|..::|.:     |....:..:||.:    ::.:..:...|.:|:.|
pombe  1607 SRIAETDGIVSDNLDIVLRRRLSQVA-----PYGKFKHQILSTHLVGYEKFENTKKTAEIYLEIA 1666

Human  1931 RVARKAGHHQTAYNALLNAGESRLAELYVERAKWLWSKGDVHQALIVLQKGV-----ELCFPENE 1990
            |::||.|..|.|:||:|.|.:.......:|.|:|.|.:|...:|:..|...:     :|.....|
pombe  1667 RISRKNGQFQRAFNAILKAMDLDKPLATIEHAQWWWHQGQHRKAISELNFSLNNNMFDLVDEHEE 1731

Human  1991 TPPEGKNML---IHGRAMLLVGRFMEETANFESNAIMKKYKDVTACLPEWEDGHFYLAKY----Y 2048
            .|...|..|   :.|:..|.:.:::.:........:...|........|.|:.|:||..:    |
pombe  1732 RPKNRKETLGNPLKGKVFLKLTKWLGKAGQLGLKDLETYYHKAVEIYSECENTHYYLGHHRVLMY 1796

Human  2049 DKLMPMVTDNKMEK--QGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYGTKAY-----EW 2106
            ::...:..:.:.|:  .|:|:..|:..|||||.||...||:|||::||||||:|.:..     :.
pombe  1797 EEEQKLPVNEQSERFLSGELVTRIINEFGRSLYYGTNHIYESMPKLLTLWLDFGAEELRLSKDDG 1861

Human  2107 EKAGRSDRVQMR-NDLGKINKVITEHTNYLAPYQFLTAFSQLISRICHSHDEVFVVLMEIIAKVF 2170
            ||..|...:..| ..|..:|..:...:..:..|.||.|.||:|||:||.:::|:.:|..|||.|.
pombe  1862 EKYFREHIISSRKKSLELMNSNVCRLSMKIPQYFFLVALSQMISRVCHPNNKVYKILEHIIANVV 1926

Human  2171 LAYPQQAMWMMTAVSKSSYPMRVNRCKEILNKAIHMKK-------SLEKFVGDATRLTDKLLELC 2228
            .:||.:.:|.:.|..||:...|..|.|.||| .:|.:|       .::.....|..:|:||:.||
pombe  1927 ASYPGETLWQLMATIKSTSQKRSLRGKSILN-VLHSRKLSMSSKVDIKALSQSAILITEKLINLC 1990

Human  2229 NKPVDGSSSTLSMSTHFKMLKKLVEEATFS---EILIPLQSVMIPTLPSILGTHANHASHEPFPG 2290
            |..::..|..:|:..||::        :|.   :::||.:|.:..|||:   ..||.|||.|||.
pombe  1991 NTRINSKSVKMSLKDHFRL--------SFDDPVDLVIPAKSFLDITLPA---KDANRASHYPFPK 2044

Human  2291 HWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDA 2355
            ....:..|:|.|:|:.|||||:|:.::|:||..|..:||||||||||.||||||:||.|.||||.
pombe  2045 TQPTLLKFEDEVDIMNSLQKPRKVYVRGTDGNLYPFLCKPKDDLRKDARLMEFNNLICKILRKDQ 2109

Human  2356 ESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALS 2420
            |:.||.|.||||.|||||:|||.|||||:|...|.||.|.|::|.:.::.:|::       ..|.
pombe  2110 EANRRNLCIRTYVVIPLNEECGFIEWVNHTRPFREILLKSYRQKNIPISYQEIK-------VDLD 2167

Human  2421 EKLK------VFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRH 2479
            ..|:      :|.:.:||:.||:|:|||:.:||:|.:|.:||..|||:.||||:|||:|||||||
pombe  2168 FALRSPNPGDIFEKKILPKFPPVFYEWFVESFPEPNNWVTSRQNYCRTLAVMSIVGYVLGLGDRH 2232

Human  2480 GENILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRL 2544
            |||||||..|||.:||||||||:||.|||.||.||||||||||:.|||.|.||.||:|.|:||||
pombe  2233 GENILFDEFTGEAIHVDFNCLFDKGLTFEKPEKVPFRLTHNMVDAMGPTGYEGGFRKASEITMRL 2297

Human  2545 MRDQREPLMSVLKTFLHDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLD-IEQRLQGVIKTR 2608
            :|..::.|||||::|||||||||::. |..||.|.||..|         ||| |.::.||.:...
pombe  2298 LRSNQDTLMSVLESFLHDPLVEWNRK-KSSSKYPNNEANE---------VLDIIRKKFQGFMPGE 2352

Human  2609 NRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPY 2645
            .    :||||||.:..||:.|.:...|.:||:||..|
pombe  2353 T----IPLSIEGQIQELIKSAVNPKNLVEMYIGWAAY 2385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATR	XP_011511226.1	UME	1119..1224	CDD:214825	25/115 (22%)
		FAT	1773..2094	CDD:280429	79/346 (23%)
		TEL1	<2135..2646	CDD:227365	249/528 (47%)
		PIKKc_ATR	2295..2569	CDD:270625	164/279 (59%)
		FATC	2615..2646	CDD:280430	15/31 (48%)
rad3	NP_595357.1	TEL1	177..2386	CDD:227365	643/2421 (27%)
		UME	862..968	CDD:214825	25/115 (22%)
		PIKKc_ATR	2051..2322	CDD:270625	164/277 (59%)
		FATC	2355..2386	CDD:280430	15/31 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	316	1.000	Domainoid score	I266
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	701	1.000	Inparanoid score	I119
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004409
OrthoInspector	1	1.000	-	-		oto146389
orthoMCL	1	0.900	-	-		OOG6_102609
Panther	1	1.100	-	-	LDO	PTHR11139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3128
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820