DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment phox2bb and Drgx

DIOPT Version :9

Sequence 1:	NP_001014818.1	Gene:	phox2bb / 544654	ZFINID:	ZDB-GENE-050407-3	Length:	284	Species:	Danio rerio
Sequence 2:	NP_001097075.2	Gene:	Drgx / 5740176	FlyBaseID:	FBgn0085369	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	99/307 - (32%)
Similarity:	129/307 - (42%)	Gaps:	108/307 - (35%)

- Green bases have known domain annotations that are detailed below.

Zfish    58 PSLTPGSCS-----LGTLRDHQSSPYAAV-PYKLFTDHGGLNE----KRKQRRIRTTFTSAQLKE 112
            |:|.|  |.     |.|| |:   |:||. ||..::.|..:::    :|||||.|||||..||:|
  Fly     8 PALHP--CGPHPPRLPTL-DY---PFAATHPYTSYSYHPAIHDETFVRRKQRRNRTTFTLQQLEE 66

Zfish   113 LERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGTGKKSDS 177
            ||..||:|||||::|||:||:||:||||||||||||||||:||.|| ........:||....|..
  Fly    67 LETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAER-LKDEQRKRENGESSSSLD 130

Zfish   178 REEDSKEAKATDPDSTG--------------------------------------GPG------- 197
            :..||:|   :.||.||                                      .||
  Fly   131 KLHDSRE---SSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHSRSPGGGMHLDS 192

Zfish   198 -PNPNPTS------------------NCGGPSPTG-----GQVSATGNGPVEQVKTSVAGMGPTA 238
             .|..|.|                  :.|.|||:|     ......|.|          |.||::
  Fly   193 SDNERPLSSNQLTATPHSASQSLGSISAGSPSPSGMHREREHTPLVGGG----------GQGPSS 247

Zfish   239 PTQGWASAPGTITSIPDSLGGPFASVLSS---LQRQNGAKATLVKTS 282
            |:.      ...|..|..:|||.:....|   ....|.|.:|...|:
  Fly   248 PSN------SRNTDSPIEVGGPMSLTTGSRMAASSNNSASSTPTPTT 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
phox2bb	NP_001014818.1	Homeobox	102..154	CDD:278475	40/51 (78%)
Drgx	NP_001097075.2	Homeobox	56..108	CDD:278475	40/51 (78%)
Drgx	NP_001097075.2	OAR	428..445	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910