Protein Alignment PON1 and poml-3

DIOPT Version :10

• Sequence 1: NP_000437.3
• Gene: PON1 / 5444
• HGNCID: 9204
• Length: 355
• Species: Homo sapiens
• Sequence 2: NP_001122440.1
• Gene: poml-3 / 6418581
• WormBaseID: WBGene00077701
• Length: 365
• Species: Caenorhabditis elegans
• Alignment Length: 380
• Identity: 107/380 - (28%)
• Similarity: 172/380 - (45%)
• Gaps: 46/380 - (12%)

Human     1 MAKLIALTLLGM-------GLALFRNHQSSYQTRLNALREVQPVELPN-CNLVKGIETGSEDLEI 57
            |.|::.:.||..       .|.:|..::.:|..|            |. |..|.|...||||:.|
 Worm     1 MLKIVLVVLLAFLVQYVFKTLLMFDINKRTYNHR------------PGPCRKVDGPVHGSEDIAI 53

Human    58 LPN-GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFT 121
            :.. .||||:|||.|...........|:|...||:::......:.|...: |...|:|||||.:.
 Worm    54 VEELNLAFITSGLVYLIEDPTQVTWKGQIFAYDLSKKTYKAESIPIVNLE-DGDGFHPHGISHWI 117

Human   122 DEDNAMYLLVVNH-PDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHY 185
            .:|.::.|.||.| ...:.::.:..|.:.:..|.|:||:|.......||:||.|...|..:||..
 Worm   118 KKDGSVRLFVVVHSKQFRHSIAILDFDKTKWQLNHVKTVRDDKFVRPNDVVATGENSFLVSNDGG 182

Human   186 FLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEK 250
            .......:.||:.|.....:||:.......:.|. ..||||.:|.|.|.::::.:....|.|:.
 Worm   183 AQTIVGNAIEMFTGFFKGGLVYFDGMNSHYLLEN-TVANGIILSRDRKTLFVSHINQETIGVFA- 245

Human   251 HANW-----TLTPLKSLDFNTLVDNISVDPETGDLWVGCHP--NGMKIFFYDSENP---PASEVL 305
               |     |:..:..::..|..||..:|.| .:||.||||  ........|:.||   ..|:||
 Worm   246 ---WDQKKITIKKISEIETLTGCDNFFIDNE-DNLWSGCHPVLKDAVGHLGDATNPNLYSQSQVL 306

Human   306 RIQNILTEEPKVT---QVYAENGTVLQGSTVASVY-KGK-LLIGTVFHKALYCEL 355
            |.:  .:.:.|.|   :|::::|.....|.:|:.: .|| |||||||....:|::
 Worm   307 RFK--FSSDLKSTEMLEVFSDDGRFTAASAIAATFDNGKQLLIGTVFRDLTHCDI 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PON1	NP_000437.3	YvrE	83..318	CDD:442613	67/245 (27%)
		Arylesterase	168..253	CDD:334656	23/84 (27%)
poml-3	NP_001122440.1	Str_synth	165..244	CDD:354965	22/79 (28%)