Protein Alignment PON1 and pon2

DIOPT Version :10

• Sequence 1: NP_000437.3
• Gene: PON1 / 5444
• HGNCID: 9204
• Length: 355
• Species: Homo sapiens
• Sequence 2: NP_001006848.1
• Gene: pon2 / 448598
• XenbaseID: XB-GENE-491654
• Length: 356
• Species: Xenopus tropicalis
• Alignment Length: 356
• Identity: 215/356 - (60%)
• Similarity: 276/356 - (77%)
• Gaps: 2/356 - (0%)

Human     1 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPNGLAFI 65
            |..|:.:||:|:.||...........|.|..|.|.|::||||.||||||.||||::|||||||||
 Frog     1 MGSLLKVTLVGILLAFLGERIMQLCHRANVFRNVDPIDLPNCQLVKGIEFGSEDIDILPNGLAFI 65

Human    66 SSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTD-EDNAMYL 129
            |||||:||:.||.|..||:|.|:||||.:|.|:.|.::.. ||||:|||||:||:.| :|:.:||
 Frog    66 SSGLKFPGLISFQPEKPGEIFLLDLNEVNPRVIPLRLSRG-FDVSTFNPHGMSTYIDPKDDTVYL 129

Human   130 LVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSW 194
            .|||||..|||||||||:|||.:|||||||:|.||.::|||||||||.||.|||.||.|..::..
 Frog   130 FVVNHPHYKSTVELFKFEEEENALLHLKTIKHDLLSSVNDIVAVGPESFYATNDFYFTDFTMKQL 194

Human   195 EMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKHANWTLTPL 259
            |::||:.||.|||||||||:.|:.|:..||||.:|.|.||:|:|:::.|:|||.||.|:|:|||:
 Frog   195 EVFLGIGWSNVVYYSPSEVKQVSSGYYSANGIAMSTDNKYIYVADVMGHRIHVLEKQADWSLTPV 259

Human   260 KSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAEN 324
            |.|..:||:||:||||.|||:|.|||||..|:|||:|::.|.|||:|:|||.::.|.|||||..|
 Frog   260 KVLQLDTLLDNLSVDPNTGDIWTGCHPNAWKLFFYNSDDVPGSEVVRVQNIHSDNPIVTQVYVNN 324

Human   325 GTVLQGSTVASVYKGKLLIGTVFHKALYCEL 355
            |||:|.|:.|.||:|||||||||||||||:|
 Frog   325 GTVIQASSCAVVYEGKLLIGTVFHKALYCKL 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PON1	NP_000437.3	YvrE	83..318	CDD:442613	139/235 (59%)
		Arylesterase	168..253	CDD:334656	49/84 (58%)
pon2	NP_001006848.1	Str_synth	168..253	CDD:354965	49/84 (58%)