Protein Alignment PON1 and pon1

DIOPT Version :10

• Sequence 1: NP_000437.3
• Gene: PON1 / 5444
• HGNCID: 9204
• Length: 355
• Species: Homo sapiens
• Sequence 2: NP_001004542.1
• Gene: pon1 / 447803
• ZFINID: ZDB-GENE-040912-6
• Length: 356
• Species: Danio rerio
• Alignment Length: 363
• Identity: 177/363 - (48%)
• Similarity: 249/363 - (68%)
• Gaps: 18/363 - (4%)

Human     1 MAKLIALTLLGMGLALF--------RNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEI 57
            |.||..|:|..:.||:|        |:...||       ||:....||||:|:||||.||||:.|
Zfish     1 MGKLAVLSLAVVALAVFIGERLVTLRHVALSY-------RELTQNYLPNCHLIKGIECGSEDITI 58

Human    58 LPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTD 122
            :.:||||:|:|:|.||: .|..:.||||..::|.:.:|.:..|.|.|. ||..:|||||||.:||
Zfish    59 IDDGLAFLSTGVKAPGL-PFCSDDPGKIYTLNLLDSEPKIKALSIKGD-FDQDTFNPHGISVYTD 121

Human   123 E-DNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYF 186
            : |..|||.|:|||...|.||:|:|.::|.:|.::|||.|:||.::|||||||.|.||.||||||
Zfish   122 DKDGTMYLFVINHPRGNSQVEIFEFVKDEHALKYIKTIEHELLHSVNDIVAVGTESFYATNDHYF 186

Human   187 LDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKH 251
            .:..|:..|.:..|.|..|:||||..|:|||:||..|||||:|.|.:|:|::::|.|.:.|.|..
Zfish   187 SNEILKIVENFFTLPWCDVIYYSPETVQVVADGFLLANGINLSLDKRYLYVSDVLKHTVTVLEIK 251

Human   252 ANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVLRIQNILTEEPK 316
            .|..|:.:|.::..:|.|||.:|.|:||||:||||||.|....|..:||.|||::|:||.:|:|.
Zfish   252 KNTVLSRVKEINVGSLADNIELDRESGDLWIGCHPNGFKFMLGDPNDPPGSEVIKIENIHSEKPL 316

Human   317 VTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCE 354
            |||||::||:|:.||:||:.|:||:|||||:||.|.|:
Zfish   317 VTQVYSDNGSVIIGSSVAAPYRGKVLIGTVYHKVLLCD 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PON1	NP_000437.3	YvrE	83..318	CDD:442613	115/235 (49%)
		Arylesterase	168..253	CDD:334656	44/84 (52%)
pon1	NP_001004542.1	YvrE	77..>288	CDD:442613	103/211 (49%)
		Str_synth	168..253	CDD:354965	44/84 (52%)