Protein Alignment PON1 and poml-4

DIOPT Version :10

• Sequence 1: NP_000437.3
• Gene: PON1 / 5444
• HGNCID: 9204
• Length: 355
• Species: Homo sapiens
• Sequence 2: NP_001040790.2
• Gene: poml-4 / 4363028
• WormBaseID: WBGene00044697
• Length: 365
• Species: Caenorhabditis elegans
• Alignment Length: 379
• Identity: 105/379 - (27%)
• Similarity: 169/379 - (44%)
• Gaps: 44/379 - (11%)

Human     1 MAKLIALTLLGM-------GLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEIL 58
            |.|::.:.||..       .|.:|..::.:|..|..           .|..|.|...||||:.|:
 Worm     1 MLKIVLVVLLAFLVQYVFKTLLMFDINKRTYNHRPG-----------QCRKVDGPVHGSEDIAIV 54

Human    59 PN-GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTFTD 122
            .. .||||:|||.|...........|:|...||:::......:.|...: |...|:|||||.:..
 Worm    55 EELNLAFITSGLAYLIEDPTQVTWKGQIFAYDLSKKTYKAESIPIVNLE-DGDGFHPHGISHWIK 118

Human   123 EDNAMYLLVVNH-PDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYF 186
            :|.::.|.||.| ...:.::.:..|.:.:..|.|:||:|.......||:||.|...|..:||...
 Worm   119 KDGSVRLFVVVHSKQFRHSIAILDFDKTKWQLNHVKTVRDDKFVRPNDVVATGENSFLVSNDGGA 183

Human   187 LDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAELLAHKIHVYEKH 251
            ......:.||:.|.....:||:.......:.|. ..||||..|.|.|.::::......|.|:.
 Worm   184 QTIIGNAIEMFTGFFKGGLVYFDGKNSHYLLEN-TVANGIIFSRDRKTLFVSHFNQETIGVFA-- 245

Human   252 ANW-----TLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFY--DSENP---PASEVLR 306
              |     |:..:..::..|...|..:|.| .:||.||||.......:  |:.||   ..|:|||
 Worm   246 --WDQKKITIKKISEIETLTGCYNFFIDNE-DNLWSGCHPVLKDALGHLGDATNPNLYSQSQVLR 307

Human   307 IQNILTEEPKVT---QVYAENGTVLQGSTVASVY-KGK-LLIGTVFHKALYCEL 355
            .:  .:.:.|.|   :|::::|.....|.:|:.: .|| |||||||....:|::
 Worm   308 FK--FSSDLKSTEMVEVFSDDGRFTAASAIAATFDNGKQLLIGTVFRDLTHCDI 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PON1	NP_000437.3	YvrE	83..318	CDD:442613	66/245 (27%)
		Arylesterase	168..253	CDD:334656	23/84 (27%)
poml-4	NP_001040790.2	Str_synth	165..244	CDD:354965	22/79 (28%)