Protein Alignment PON1 and smp-30

DIOPT Version :10

• Sequence 1: NP_000437.3
• Gene: PON1 / 5444
• HGNCID: 9204
• Length: 355
• Species: Homo sapiens
• Sequence 2: NP_001262580.1
• Gene: smp-30 / 41786
• FlyBaseID: FBgn0038257
• Length: 306
• Species: Drosophila melanogaster
• Alignment Length: 283
• Identity: 57/283 - (20%)
• Similarity: 93/283 - (32%)
• Gaps: 84/283 - (29%)

Human   116 GISTFTDEDNAMY-------------LLVVNHPD---------------------AKSTVELFKF 146
            ||:.:..:.|.:|             |.|.|.|.                     ||.|..||:.
  Fly    40 GINRYDFKQNKVYRAKIEGEIFASFILPVENKPQEFAVGCGLRTVIVQWDGVSAVAKVTRTLFEV 104

Human   147 QEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPS 211
            |.:      ||..|      |||........|||.......|.:.| |:   |..:|:.....|:
  Fly   105 QPD------LKENR------LNDAKTDPNGRFYGGTMADSGDIFTQ-WK---GELYSWQAGGQPN 153

Human   212 EVRVVAEGFDFANGINISPDGKYVYIAELLAHKI--HVYEKHANWTLTPLKSLDFNTL------- 267
            .:|   .....:||:......|..|..:...|::  :.|.:.......|....|...:
  Fly   154 AIR---SKVGISNGLAWDVKAKKFYFIDTNNHEVLAYDYNQSTGAVSNPKVIFDLRKIRPEGPLF 215

Human   268 VDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASEVL--------RIQNILTEEPKVTQVYAEN 324
            .|.::||.: |:::|... ||..:|   ..||...::|        :|.::....|.:..:|.
  Fly   216 PDGMTVDTD-GNIYVATF-NGGTVF---KVNPSTGKILLEIKIPTTQITSVAFGGPNLDILYV-- 273

Human   325 GTVLQGSTVASVYKGKLLIGTVF 347
                   |.|:.:......||.|
  Fly   274 -------TTANKFDQPKPAGTTF 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PON1	NP_000437.3	YvrE	83..318	CDD:442613	51/252 (20%)
		Arylesterase	168..253	CDD:334656	18/86 (21%)
smp-30	NP_001262580.1	SGL	18..277	CDD:462480	53/269 (20%)