Protein Alignment NLGN3 and CG10175

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Alignment Length: 652
• Identity: 190/652 - (29%)
• Similarity: 283/652 - (43%)
• Gaps: 170/652 - (26%)

Human    46 THFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNI 110
            |..||:||......|...|....:.|:.|.|||.|.:||...||...|||||:|:.....||..
  Fly   158 TSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHK- 221

Human   111 HTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVY---VPTEDVKRISKECARKPNKKICRKG 172
                           |: |:.|:  :.:||||::||:   :|.:|      |.|.:|.
  Fly   222 ---------------NM-ILDTF--KGDEDCLFVNVFTTQMPKDD------ESAEQPK------- 255

Human   173 GSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NV 230
                                       .||||::|||.:..|:||    |.|  ||       ::
  Fly   256 ---------------------------LPVMVWLHGGGFSFGSGN----SFL--YGPDYLVAEDI 287

Human   231 IVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVS 295
            :::|||||:|.||||:.|.. |.||.||.||:.||:||.:|||.|||||.::|:||...|||.|.
  Fly   288 VLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQ 351

Human   296 LLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADK---VGCNVLDTVDMVDCLRQKSA 357
            ||.||..::|||.|||.||||||:.|:::....:..:.||..   ||.|  .|.|::|.||:..|
  Fly   352 LLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGAN--KTEDILDFLRRVPA 414

Human   358 KELVE-------QDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFL-------------NYDI- 401
            .:|||       .:.|.....:.|.||::|....|..|....:..||             |.|:
  Fly   415 MKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVA 479

Human   402 -MLGVNQGEGLKFVEGV-VDPEDGVSGTDFDYSVSNFVDNLYG--------YPEGKDTLRETIKF 456
             |.|.|..|.:.|:..: .:|:           :.:.::|.:|        ..|..|.:...|:.
  Fly   480 YMTGYNTHEAMLFIRRLRKNPQ-----------LLSIIENDFGRLVPQDLNVTESHDRVTREIRS 533

Human   457 MY-------TDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG-SPTYFYAF------- 506
            .|       .:..|.         ::||.||..:::....||..||::| :|.|.|.|
  Fly   534 FYLGSKHVGIESVDE---------MIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDGSLG 589

Human   507 -YHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 570
             |.....:.:|.   ..||||:.|:|...... ..|.|   ...:|.:...::..||||||.|.|
  Fly   590 LYKRMLGIPRPG---VCHGDELGYLFKFGFFN-LSLDP---KSMEVQVKNRMVRMWTNFAKYGSP 647

Human   571 NKPVPQDTKFIHTKANRFEEVAWSKYNPRDQL----YLHIGLKPRVRDHYRATKVAFWKHLVPHL 631
            . |..:| ..:.||        |:..:|.:.:    |:.|.....::.:....:..||..:..|
  Fly   648 T-PDSED-PMLTTK--------WAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMYQH- 701

Human   632 YN 633
            ||
  Fly   702 YN 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	185/641 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694
CG10175	NP_001287487.1	COesterase	155..695	CDD:395084	185/641 (29%)