Protein Alignment NLGN3 and Nlg1

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Alignment Length: 905
• Identity: 256/905 - (28%)
• Similarity: 394/905 - (43%)
• Gaps: 221/905 - (24%)

Human     5 LGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHF--------------------- 48
            :|..:.::.|....|||:.      ..|||.: :||.|::..||
  Fly    59 IGDITTTIQPDSDPGRSIG------HQALRRA-KAPPPSLELHFRQNLNKLFAGDETTHVGHTNA 116

Human    49 ----------------------------------------------GKLRG--ARVPLPSEILGP 65
                                                          |:|.|  .|..:.|. |..
  Fly   117 TDNTTAAVLATDEGSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSG-LRQ 180

Human    66 VDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVP---EVMLPVWFTANL 127
            |||:||:|||..|.|.:||:||..|..|.|::.|.|.||||||.:....|   |.|..... .:|
  Fly   181 VDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARH-KHL 244

Human   128 DIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDE 192
            ..:..|::..:|||||||:|||.|:.:...|:.|
  Fly   245 SRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYA------------------------------- 278

Human   193 DIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAK-GNY 256
                     |:||:||.|:...:||..|||:|:|||.|||:|:|||:||||||.....|.. .||
  Fly   279 ---------VLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANY 334

Human   257 GLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSW 321
            .|||||.||.|:.|||..||||..|:|:.|...||:||:.|.:|..:.|||.|||:.||||:|.|
  Fly   335 ALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDW 399

Human   322 AVNYQPVKYTSLLADKVGCNVLDTVD------MVDCLRQKSAKELVEQDIQPARYHVAFGPVIDG 380
            |.:.|.::.|..:|..:.|.:.:.|:      ::||||.:..::::.......::..:.||::||
  Fly   400 AASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSLGPIVDG 464

Human   381 DVIPDDPEILMEQ--GEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYG- 442
            .|||:.|..:|..  ..|..||::.|:.:.|....:..:. .|:|:.        .|..|||..
  Fly   465 HVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA-LEEGLR--------ENERDNLLRF 520

Human   443 YPEGKDTLRETIKF---------MYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG 498
            |.:.:..:|..:..         ||.:.....|.| .|..::.:.:|.:.|.|.:.|...||...
  Fly   521 YMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILSDARVVGPLLQTGMFHADVN 584

Human   499 SPTYFYAFYHHCQSLMKPAWSDAAH------GDEVPYVFGVPM--VGPTDLFPC-NFSKNDVMLS 554
            ...|.|.|.|:      .|....||      |:|:.::||.|:  .||   ||. |::..:.:||
  Fly   585 RRNYMYVFGHN------SATGPFAHLPHSIMGEELAFIFGAPLAAAGP---FPSGNYTVQEKLLS 640

Human   555 AVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFE--EVAWSKYNPRDQLYLHIGLKPRVRDHYR 617
            ..||.|||||.|||:|.  .|....||::.|..::  ::.|.::|.|.|.||:||:.|.|...||
  Fly   641 EAVMAYWTNFVKTGNPK--APWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYR 703

Human   618 ATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPD----TTHSSHITRRPNG-----KTWS--TKR 671
            ...:.||...:|...|     ...:...::..|.    |.|.|....|.:|     :|..  .:.
  Fly   704 QIYMNFWNKELPDELN-----QIAAIQEQLQKPGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQE 763

Human   672 PAIS-PAYSNEN----AQGSWN------------GDQDAGPLL-----VENPRDY---------- 704
            |::: |..|.|:    |:..:|            |..|...|:     :|:..|:
  Fly   764 PSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQAPPETVAK 828

Human   705 -STELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAPEEEL 763
             ...:.:.||:...::.||:|.:.....|:.:||.:.|..|:|:.|........|.:|||
  Fly   829 SEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAPKLGGTILSYDGANDEEL 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	209/685 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694		15/76 (20%)
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	205/615 (33%)