Protein Alignment NLGN3 and Nlg3

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Alignment Length: 916
• Identity: 299/916 - (32%)
• Similarity: 429/916 - (46%)
• Gaps: 178/916 - (19%)

Human    38 QAPAP----TVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRN 98
            |.||.    .:||..|.:.|..|.|....|.||:.|.|:|||:||:|..||:||.....|||::.
  Fly   148 QLPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKK 212

Human    99 ATHFPPVCPQ---NIH--TAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISK 158
            |..|.|||||   :||  ||..|.| |......|..:..|:|..:|||||||:|||.:...|.|.
  Fly   213 ADRFSPVCPQRLPDIHNETAALERM-PKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSS 276

Human   159 ECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAK---PVMVYIHGGSYMEGTGNMID 220
            ..:...:     .|.|.:...|...:.:..........||:.   ||:|::||.||...:||..|
  Fly   277 GSSSSSS-----AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYD 336

Human   221 GSILASYGNVIVITLNYRVGVLGFLSTG-DQAAK--GNYGLLDQIQALRWVSENIAFFGGDPRRI 282
            ||:|||||.::|:|:|||:||||||:.. |:.:|  .||||:|.|.||.|:.||||.|||||..|
  Fly   337 GSVLASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSI 401

Human   283 TVFGSGIGASCVSLLTLSHH-SEG-LFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC-NVLD 344
            |:.|.|.||:||..|..|.. .|| ||.|||:.|||.|:.|::...|.||.:::|..|.| :.|.
  Fly   402 TLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLP 466

Human   345 TVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVI---------PDDPE------------ 388
            ...::.|||:|:..:|:...|:|..:..||||.|||.||         |..|.
  Fly   467 HAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAG 531

Human   389 ------------------------ILMEQ---GEFLNYDIMLGVNQGEG-LKFVEGVVDPEDGVS 425
                                    :||.:   .:...||:|.||.:.|. ..|..|  |.:.|:.
  Fly   532 NGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSG--DVQYGIE 594

Human   426 GTDFDYSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDWADRDNP-----ETRRKTLVALFTDHQ 482
            .......:..:|.|.|.:     .|.|   ||...||||   :.|     ..|.:||.|| :|.|
  Fly   595 ADRRSRILKAYVRNTYTF-----HLNEIFATIVNEYTDW---ERPVQHPINIRDETLEAL-SDAQ 650

Human   483 WVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFS 547
            .|.|:..|.|||:.....:|.|.|.:..:....|......||:::||:||.|:||..:.|..|::
  Fly   651 VVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYT 715

Human   548 KNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIH---TKANRFEEVAWSKYNPRDQLYLHIGLK 609
            |.::.||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.|:.|....:.||:...|
  Fly   716 KTEISLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTK 776

Human   610 PRVRDHYRATKVAFWKHLVPHL------------YNLHD-------------------------- 636
            |::::||||.:::||.:|:|.|            :.|||
  Fly   777 PKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAA 841

Human   637 ----MFHYTSTTTKV------PPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQ 691
                |.::|..|.:|      ..|.::...:.||...||.:.      ......::|.|:.:..|
  Fly   842 NAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKIYP------DDMMDGDHAGGAASASQ 900

Human   692 DAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELG 756
            |:.....     |||.||||||:|.|||.||||.||.:||::||.|   |.:|.||......|.|
  Fly   901 DSDGFAA-----YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTR---LSEPRPQTKLKRQENG 957

Human   757 AAPEEELAALQLGPTHHECEAG---PPHDTLRLTALPDYTLTLRRSPD--DIPLMTPNTITMIPN 816
            ..|......|:....|.:.:..   ..|..::...||        .|:  |||...|..    |.
  Fly   958 QMPNNICGDLETLTIHAKSDPATILSHHHAMQHHQLP--------PPEFADIPHRAPPP----PK 1010

Human   817 SLVGLQ 822
            .:..||
  Fly  1011 HMKSLQ 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	233/661 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694		10/54 (19%)
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	231/657 (35%)