Protein Alignment NLGN3 and alpha-Est1

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_524269.3
• Gene: alpha-Est1 / 40909
• FlyBaseID: FBgn0015568
• Length: 565
• Species: Drosophila melanogaster
• Alignment Length: 672
• Identity: 185/672 - (27%)
• Similarity: 279/672 - (41%)
• Gaps: 141/672 - (20%)

Human     1 MWLRLGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGP 65
            |.:|:|...|.......:|..:        :..|..|: ....|.|..|::||.|    ...|..
  Fly     1 MEIRVGVGDLLKMGTKLIGHKI--------VQYRLGTK-QTKVVCTRDGQVRGHR----RRTLYD 52

Human    66 VDQYL---GVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANL 127
            .:.|.   |:|:|.||:||.||..|:||..|.|:|:.| :|...|...|..             |
  Fly    53 EEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDCT-YPRAKPMQKHFV-------------L 103

Human   128 DIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDE 192
            .||     |.:|||||||||     .||:..:   ||
  Fly   104 SIV-----EGSEDCLYLNVY-----SKRLRSD---KP---------------------------- 127

Human   193 DIRDSGAKPVMVYIHGGSYMEG-TGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQ--AAKG 254
                   .||:|:|:||.:..| .|............:|:|:|.|||||.|||||..|:  ...|
  Fly   128 -------LPVIVWIYGGGFQFGEAGRDFYSPDYFMQQDVVVVTFNYRVGALGFLSLADRDLDVPG 185

Human   255 NYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALS 319
            |.||.||:.||||:|:|||.|.|||:.|||.|...||:.|..|..:..:.|||.:||:||||...
  Fly   186 NAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGAASVHALMTTEQTRGLFHKAIMQSGSMFC 250

Human   320 SWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKS-AKELVEQDI-----QPARYHVAF---- 374
            .|| |....::...||.::|.:..:....|....||: |.|:..|.|     :..|.:|.|
  Fly   251 EWA-NEPSGRWAYRLACQLGYSGSENEKEVFRYLQKAPASEMAAQGITLVSQEERRQYVLFPFTP 314

Human   375 --GPVIDGD-VIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNF 436
              .|.|..| |:|.....::.:....:..::||.|..|||...:..:..|:.:... |:..:...
  Fly   315 VVEPYITRDCVLPRCHREMLPEAWGNDLPLILGGNSFEGLFSYQSTLHDEEHMLSA-FEVLIPRE 378

Human   437 VDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQW--VEPSVVTADLHARYGS 499
            :.........||.||: .|....|.|.|...|. .:.|..|...|.|  :..:|:....||. .:
  Fly   379 IREKSTQSHLKDLLRQ-FKVDNFDDATRGRMEF-NECLHILSVKHFWHGIHRTVLARLSHAP-AT 440

Human   500 PTYFYAF------YHHCQSLM--KPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAV 556
            |||.|.|      ::|.:.:|  |.. ...:|.|::.|:|...:....|       |:.:....:
  Fly   441 PTYLYRFDVDSPHFNHFRQVMCGKHV-RGVSHADDLSYLFYHILANKVD-------KSSMEYQTI 497

Human   557 --VMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPR-DQLYLHIG--LKPRVRDHY 616
              ::..|..||:..:||.|             :.....|...:.: .|:.|:||  |:..|....
  Fly   498 QRLVGMWVAFARNDNPNCP-------------QIGPTTWEALDEKGPQMCLNIGKQLEFIVLPES 549

Human   617 RATKVAFWKHLVPHLYNLHDMF 638
            :..::  |    ..||:.:|:|
  Fly   550 KQNRI--W----DRLYDKNDLF 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	173/617 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694
alpha-Est1	NP_524269.3	COesterase	31..555	CDD:395084	173/617 (28%)