Protein Alignment NLGN3 and alpha-Est3

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 153/635 - (24%)
• Similarity: 250/635 - (39%)
• Gaps: 157/635 - (24%)

Human    44 VNTHFGKLRGARVPLPSEILGPVDQYLG---VPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPV 105
            |||..|.:.|.:.   :.:.|  |:|:.   :|||.||:|..||:.|.|...||...:.|. |..
  Fly     6 VNTTSGPVLGKQC---TGVYG--DEYVSFERIPYAQPPVGHLRFMAPLPVEPWSQPLDCTK-PGQ 64

Human   106 CPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICR 170
            .|...:          .::..|:.|        |||||||||....|..|
  Fly    65 KPLQFN----------HYSKQLEGV--------EDCLYLNVYAKELDSPR--------------- 96

Human   171 KGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNM-IDGSILASYGNVIVIT 234
                                        ..|::|:..||.:.:|.... :.........:|:|:|
  Fly    97 ----------------------------PLPLIVFFFGGGFEKGDPTKELHSPDYFMMRDVVVVT 133

Human   235 LNYRVGVLGFLSTGDQA--AKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLL 297
            ::||||.|||||..|.|  ..||.||.||:.|:.|:.||...|.|||:.:|.||...||:.|..|
  Fly   134 VSYRVGPLGFLSLNDPAVGVPGNAGLKDQLLAMEWIKENAERFNGDPKNVTAFGESAGAASVHYL 198

Human   298 TLSHHSEGLFQRAIIQSGSALSSWA---VNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKE 359
            .|:..:||||.:||:|||:.|.|||   :...|.:....|..:...:|.|.: ::|.|::...::
  Fly   199 MLNPKAEGLFHKAILQSGNVLCSWALCTIKNLPHRLAVNLGMESAEHVTDAM-VLDFLQKLPGEK 262

Human   360 LVEQDIQPARYHV-----AFGPVI-----DGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFV 414
            ||...:..|..|:     .|||::     :...:|:.|:.|:::.......:::.....|||...
  Fly   263 LVRPYLLSAEEHLDDCVFQFGPMVEPYKTEHCALPNHPQELLDKAWGNRIPVLMSGTSFEGLLMY 327

Human   415 EGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEG------KDTLRETI------KFMYTDWADRD-- 465
            ..|             ......:.:|...||.      |..|.:.:      :...|.:...|
  Fly   328 ARV-------------QMAPYLLTSLKKEPEHMLPLDVKRNLPQALARHLGQRLQETHFGGNDPS 379

Human   466 --NPETRR----------------KTLVALFTDHQWVEPSVVTADLHA-RYGSPTYFYAFYHHCQ 511
              :||:.:                |||      ...|:.|..:..|:. .:.|||:.:....:|.
  Fly   380 AMSPESLKAYCEYASYKVFWHPILKTL------RSRVKSSSASTYLYRFDFDSPTFNHQRLKYCG 438

Human   512 SLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQ 576
            ..::    ..||.|:..|::........|.....|...:.|:..:     |:||:|.:||
  Fly   439 DKLR----GVAHVDDHSYLWYGDFSWKLDKHTPEFLTIERMIDML-----TSFARTSNPN----- 489

Human   577 DTKFIHTKANRFEEVAWSKYNPRDQL-YLHIGLKPRVRDHYRATKVAFWK 625
             .|.|..:..|.:|  |...|.:..| .|:|....::.:.....|:..|:
  Fly   490 -CKLIQDQLPRAKE--WKPLNSKSALECLNISENIKMMELPELQKLRVWE 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	152/632 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	152/632 (24%)