Protein Alignment NLGN3 and alpha-Est7

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_524261.1
• Gene: alpha-Est7 / 40901
• FlyBaseID: FBgn0015575
• Length: 572
• Species: Drosophila melanogaster
• Alignment Length: 646
• Identity: 174/646 - (26%)
• Similarity: 262/646 - (40%)
• Gaps: 183/646 - (28%)

Human    34 RASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRN 98
            |.||.... ..:|.:|::||.:.....::  |...:.|:|||.||:||.||..|:.|..|..:|:
  Fly    26 RQSTNETV-VADTEYGQVRGIKRLSLYDV--PYFSFEGIPYAQPPVGELRFKAPQRPIPWERVRD 87

Human    99 ATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARK 163
                   |.|....||     .|.|.  .|.|     |.:|||||||||  |.:|         |
  Fly    88 -------CSQPKDKAV-----QVQFV--FDKV-----EGSEDCLYLNVY--TNNV---------K 122

Human   164 PNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG 228
            |:|                                |:||||:||||.::.|..|.      ..||
  Fly   123 PDK--------------------------------ARPVMVWIHGGGFIIGEANR------EWYG 149

Human   229 -------NVIVITLNYRVGVLGFLS--TGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITV 284
                   :|:::|:.||:|.|||:|  :.:....||.||.||:.||:|:..|.|.|||||..|||
  Fly   150 PDYFMKEDVVLVTIQYRLGALGFMSLKSPELNVPGNAGLKDQVLALKWIKNNCASFGGDPNCITV 214

Human   285 FGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVN----YQPVKYTSLLADKVGCNVLDT 345
            ||...|.:....:.|:..::|||.|.|:|||||:..||.|    :.|.:...|:..|...|   .
  Fly   215 FGESAGGASTHYMMLTDQTQGLFHRGILQSGSAICPWAYNGDITHNPYRIAKLVGYKGEDN---D 276

Human   346 VDMVDCLRQKSAKEL--VEQDI-----QPARYHVAFGPVID-----GDVIPDDPEILMEQGEFLN 398
            .|:::.|:...||:|  ||:::     :..:...||||.::     ..||...|:.:|:.....:
  Fly   277 KDVLEFLQNVKAKDLIRVEENVLTLEERMNKIMFAFGPSLEPFSTPECVISKPPKEMMKTAWSNS 341

Human   399 YDIMLGVNQGEGL------KFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTL-RETIKF 456
            ..:.:|....|||      |.:..|:...|  :||.|             .|  |:.| .|..|.
  Fly   342 IPMFIGNTSYEGLLWVPEVKLMPQVLQQLD--AGTPF-------------IP--KELLATEPSKE 389

Human   457 MYTDWA------DRDNPETRRKTLVALFTDHQWVEPSVVTADLHARY----GSPTYFYAFYHHCQ 511
            ....|:      .|...|:.....:.|.:.:.:|.|::..  :|:|:    |:|.|||.:....:
  Fly   390 KLDSWSAQIRDVHRTGSESTPDNYMDLCSIYYFVFPALRV--VHSRHAYAAGAPVYFYRYDFDSE 452

Human   512 SLMKP--------AWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMT--YWTNFAK 566
            .|:.|        .....:|.|::.|.|       :.|......|.......:..|  .||.||.
  Fly   453 ELIFPYRIMRLGRGVKGVSHADDLSYQF-------SSLLARRLPKESREYRNIERTVGIWTQFAA 510

Human   567 TGDPNKP------------------------VPQDTKFIHTKANRFEEVAWSKYNPRDQLY 603
            ||:|...                        :..|.|||       :...|.|....:.||
  Fly   511 TGNPYSEKINGMDTLTIDPVRKSDEVIKCLNISDDLKFI-------DLPEWPKLKVWESLY 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	171/640 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694
alpha-Est7	NP_524261.1	COesterase	34..514	CDD:395084	162/578 (28%)