Protein Alignment NLGN3 and CG3841

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_609300.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 657
• Identity: 176/657 - (26%)
• Similarity: 261/657 - (39%)
• Gaps: 186/657 - (28%)

Human    27 WFLSLALRASTQAPA-----PTVNTHFGKLRGARVPLPSEILG--PVDQYLGVPYAAPPIGEKRF 84
            |.|.|.|...|.|..     |.|....|:::|..:    :..|  .:..:.|:.||..|:|:.||
  Fly     9 WALLLILIGFTTAVTFIGDDPVVELSLGRIQGDTM----QSFGNKTIYAFRGIRYAQSPVGQLRF 69

Human    85 LPPEPPPSWSG-IRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYV 148
            ..|.|..||.. :.|||....||||      |.|                :...:||||.:||:.
  Fly    70 ANPVPETSWGDEVFNATSDSLVCPQ------PGV----------------VSLMSEDCLKINVFT 112

Human   149 PTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYME 213
                                         |..||                ..|||||||||:.:.
  Fly   113 -----------------------------KSFED----------------KFPVMVYIHGGANVL 132

Human   214 GTGNMIDGSILASY---------GNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVS 269
            |:|:       :||         .:|:.:..|||:|.||||||.....|||:|.|||:.||.||.
  Fly   133 GSGH-------SSYEAGPQYLLDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVR 190

Human   270 ENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLL 334
            ::|:.|||||..:|:.|...|:..|||...|..|.|||.|||:.||||.:.:.::  .:.:|..|
  Fly   191 DHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDID--NLFWTRKL 253

Human   335 ADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARY---HVAFGPVIDGDVIPDDPEILMEQGEF 396
            |.::||.:.|..|:|:|||.::...:||.......|   ::.:...|||..:.:.|..|:::|.|
  Fly   254 ARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQLVNMKWNYEIDGHFLHNHPTELIKEGNF 318

Human   397 LNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYS--------------VSNFVD---NLYGYP 444
            ....:::.....|                   |||:              .|||||   .|:.|.
  Fly   319 NKVPLLISFTANE-------------------FDYNANVHLENQHLLHDFASNFVDYAPELFLYR 364

Human   445 EGKDTLRETIKFMY----TDWADRDNPETRRKTLVALFTD-------HQWVEPSVVTADLHARYG 498
            .... :.|.:|..|    |...:.:|.|    ....:|:|       |:.|:        .|.:.
  Fly   365 HDAQ-IGEKLKDFYLGDNTTEINSENIE----NFGQIFSDAYIGHGVHRLVQ--------LASHF 416

Human   499 SPTYFYAF-YHHCQSLMKPAWSD-----AAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVV 557
            :|.|:... |...|||..|...:     ..|.|::.||......||  |...|.|  ||.:...:
  Fly   417 TPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGP--LMAANDS--DVFMMERL 477

Human   558 MTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVA 622
            .:::|:|||||.|.....                .|...|......|:.|:..:|.....:.:.|
  Fly   478 TSWFTHFAKTGTPLNSTD----------------IWPPCNSTVLKMLYNGVVTQVGSPGYSNRYA 526

Human   623 FWKHLVP 629
            .|..|.|
  Fly   527 VWDKLFP 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	167/637 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694
CG3841	NP_609300.1	COesterase	27..528	CDD:395084	167/632 (26%)