Protein Alignment NLGN3 and Glt

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_477504.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Alignment Length: 791
• Identity: 179/791 - (22%)
• Similarity: 277/791 - (35%)
• Gaps: 239/791 - (30%)

Human    40 PAP-TVNTHFGKLRGARVPLP--SEILG----------PVDQYLGVPYAAPPIGEKRFLPPEPPP 91
            |.| ...|.:.:.:.|.|..|  .:|||          ||:.:||:.|.....|..||...: |.
  Fly    45 PVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PI 108

Human    92 SWSGIRNATHFPPVCPQNIHTAVPE---VMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDV 153
            .:.|..|||...|.|.|     .||   :.|......|:|           |||.|::|.|
  Fly   109 GYQGRVNATVQSPNCAQ-----FPELDRLRLSESRGENVD-----------DCLTLDIYAP---- 153

Human   154 KRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNM 218
                                .||.:                     .||:|::||....:|....
  Fly   154 --------------------EGANQ---------------------LPVLVFVHGEMLFDGGSEE 177

Human   219 IDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRIT 283
            .....:.. .:|:::::|||:...||||.......||..|.|...||.|:..|:..|||:..::|
  Fly   178 AQPDYVLE-KDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVT 241

Human   284 VFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC-------N 341
            :.|...||:....|:||..:..|||:.|:|||:||:.:.::.||:...|..|....|       :
  Fly   242 LVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPS 306

Human   342 VLDTVDMVDCLRQKSAKELVE--QDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLG 404
            ......:.|||.:....:||.  :.:.....|:....:....::..||     .|...::...|.
  Fly   307 AQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDP-----LGFLPSHPASLA 366

Human   405 VNQGEGLKFVEGVV-DPEDGVSGTDFDY-------SVSNFVDNLYGYPEGKDTLRETI----KFM 457
            .|....|..:.|.. |....:....:|.       :||:::|.:         ||.|.    ..:
  Fly   367 TNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVV---------LRHTAPPSEHRL 422

Human   458 YTDWADRDNPETRRKTLVALFT-------DHQWVEPSVVTADLHARYGS-------------PTY 502
            :..||.|:           :||       ..|.|.|.::....:..|.:             |.|
  Fly   423 WKQWALRE-----------IFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAY 476

Human   503 FYAF-----YHHCQSLMKPA--WSDAAHGDEVPYVFGVP----MVGPTDLFPCNFSKNDVMLSAV 556
            .|.|     :|....|..|.  ..||:..|:..|:|..|    .:.|.|.          .||..
  Fly   477 LYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDR----------SLSRA 531

Human   557 VMTYWTNFAKTGDPNKPV---PQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRA 618
            ::|.|.|||.||.||...   ||.|               |:|.|    :|      |..::.::
  Fly   532 LVTMWVNFATTGVPNPSSGVWPQAT---------------SEYGP----FL------RFTNNQQS 571

Human   619 TKVAFWKHLVPH----LYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYS 679
            .     ..|.||    :|..:....|..||...||..||.::..|      |.:|.||.....|:
  Fly   572 P-----LELDPHFGEGIYLPNYRVIYKPTTNFSPPITTTTTTTTT------TTTTSRPYAYNPYA 625

Human   680 N-----ENAQGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQE 739
            |     .....:|:   .|.|..|........|.                    :..|:.:||::
  Fly   626 NWQNRPSQQHPNWH---PADPEYVRAQEARQQEF--------------------IREREQRRREQ 667

Human   740 PLR--QPSPQR 748
            .||  |..||:
  Fly   668 QLRDQQRYPQQ 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	148/654 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		2/24 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694		12/53 (23%)
Glt	NP_477504.1	COesterase	58..579	CDD:395084	147/648 (23%)
		Casc1_N	681..>717	CDD:464947