Protein Alignment NLGN3 and Nlg2

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_523496.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Alignment Length: 908
• Identity: 267/908 - (29%)
• Similarity: 400/908 - (44%)
• Gaps: 226/908 - (24%)

Human    43 TVNTHFGKLRGARV---PLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPP 104
            ||.|.:|.|||..|   ||       |:.:||:|||:||:|..||:||..|.:|..:|:|..|.|
  Fly   184 TVKTKYGLLRGIVVRSSPL-------VEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSP 241

Human   105 VCPQNIHTAV--PEVML--PVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPN 165
            ||||||....  ||.:|  |....|.|..:...::..:|||||||:|||.|
  Fly   242 VCPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYE-------------- 292

Human   166 KKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNV 230
                      .::|..:..|..|:....:      ..:|:|||.||...:||..|||.||::|||
  Fly   293 ----------TRRQRRNTDDTTGEPKTKL------STVVFIHGESYDWNSGNPYDGSELAAHGNV 341

Human   231 IVITLNYRVGVLGFLST-GDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCV 294
            ||:|:|:|:|:.|||.| |.::|:||:||:|.:..|.|:.||:..|||||:.||:.|.|.||...
  Fly   342 IVVTINFRLGIFGFLKTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLA 406

Human   295 SLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCN---VLDTVDMVDCLRQKS 356
            ::|.:|..:..|.||.::.||||||.||:...|:.....:|::.||:   :.|  |:..|||.||
  Fly   407 NILVVSPVASDLIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYD--DLAPCLRTKS 469

Human   357 AKELVEQDIQPARYHVAFGPVIDGDVI------------PDDPEILMEQG-EFLNY---DIMLGV 405
            ..||:...:...|:.|.|.|.:||.||            |....|:...| |:.|:   |::..:
  Fly   470 VAELLAVKVDHPRFLVGFAPFVDGTVISPGANPLGSTTLPLGSAIVSTSGIEYANFPKRDLIFCL 534

Human   406 NQGEGLKFVE-GVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDW--ADR 464
            ...|  .::: ...|.|.|.:.|..|..:..||.|.:.|     .|.|   .:|..||||  |.|
  Fly   535 TSVE--SYLDLSAQDLEFGFNETRRDRILRTFVRNNFHY-----HLNEIFAVLKNEYTDWEKAIR 592

Human   465 DNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPY 529
             ||.:.|...:...:|.....|.:....:|:..|...||..|.|.......|..|.:..|::||:
  Fly   593 -NPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLHFKHKTIEEEYPQRSGSVRGEDVPF 656

Human   530 VFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNK-------PVPQD---------- 577
            ..|:||   :.|||.|::..:..:..:::.|.:||||||:||:       |.|.:
  Fly   657 WLGLPM---SPLFPHNYTTQERQIGRLMLRYLSNFAKTGNPNQSTAKSVLPNPNEVLETALHQQK 718

Human   578 -------------------------TKFIHTKAN------RFEEVA------------------- 592
                                     :..:|.|.:      |..:.|
  Fly   719 KRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLRSNDAAFTQLGISSERDVGSYDGDE 783

Human   593 ---WSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHL---YNLHD--MFHY--------- 640
               |..|:..:|||:.:|.|..::.|||..|::.|.:|:|.|   :|::|  |.|:
  Fly   784 LPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQLHRHFNINDQSMRHHQFQDDMNNR 848

Human   641 -------------------------TSTTTKVPPPDTTHSSHITR--RPNGK-TWSTKRPAISPA 677
                                     .|.||..|||....|::.|:  .|.|. |.:|....|..|
  Fly   849 DLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPSTNATQALNPLGTGTPTTTECGIDGA 913

Human   678 YS-NENAQGSWNGDQDAGPLLVENPRD-------------------------YSTELSVTIAVGA 716
            .| :|........|...|.:.||..:|                         |:|.|..|:|||.
  Fly   914 MSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLELLRRLGGKQFQSYTTALIATVAVGC 978

Human   717 SLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAPEEELAALQLGPTHHECEAGP 779
            .||.||||.||.:|::::||.::...:...|.|..:......   :|.||..|  ...|.:||
  Fly   979 FLLILNVLIFAGIYHQREKRARDAKTKEELQEGDNSKNSSIL---KLNALMGG--GGACGSGP 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	211/683 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694		15/52 (29%)
Nlg2	NP_523496.1	COesterase	182..729	CDD:395084	196/594 (33%)