Protein Alignment NLGN3 and CG6414

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_570089.1
• Gene: CG6414 / 31352
• FlyBaseID: FBgn0029690
• Length: 583
• Species: Drosophila melanogaster
• Alignment Length: 659
• Identity: 182/659 - (27%)
• Similarity: 267/659 - (40%)
• Gaps: 192/659 - (29%)

Human    44 VNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQ 108
            :.||.|:...|              ::|||||.||:.:.||.||.|...|.|.|.|....|:|.|
  Fly    45 LTTHNGRHMRA--------------FMGVPYAEPPLDDLRFRPPVPKAPWEGERLAIKDAPICLQ 95

Human   109 NIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGG 173
            ...           |..::      |.|.:|||||||||.|
  Fly    96 RDP-----------FRRDM------ILEGSEDCLYLNVYTP------------------------ 119

Human   174 SGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NVI 231
                              |..|.:|:.||||:.|||.:..|:|      |.:.||       :::
  Fly   120 ------------------ERPRTNGSLPVMVWFHGGGWQCGSG------ISSFYGPDFLLDHDIV 160

Human   232 VITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSL 296
            :::.|:|:|.||||||......||.||.||::.|.||..|||.|||||..:||||...|.:.|:.
  Fly   161 LVSANFRLGPLGFLSTETLDCPGNNGLKDQLEVLHWVRANIASFGGDPNSVTVFGESAGGASVTY 225

Human   297 LTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVK------YTSLLADKVGC-NVLDTVDMVDCLRQ 354
            ..||..|.||..|.|.|||:..:.||   ||..      ..:.||..||| |..:..:.::|||:
  Fly   226 HMLSEKSRGLLHRGIAQSGTYFNPWA---QPAHKGVAAGRATKLAQIVGCGNAGEWPEKLECLRK 287

Human   355 KSAKELVEQ-------DIQPARYHVAFGPVIDGDVIPDDPEILMEQGEF-------------LNY 399
            |.|:::|..       |..|.   :.|.||:       :||   ..|.|             |..
  Fly   288 KPAEDIVASLYDMFVWDFDPM---IPFPPVV-------EPE---HDGAFLTVAPRQAAKPHGLQL 339

Human   400 DIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETI-----KFMYT 459
            .:|:|....|||.....:::....::  :|.......:..:..|....|::|:||     .|.:.
  Fly   340 PLMVGATAEEGLLKTAALLNLPQLLA--EFKSQFEQVLPVVLNYDHHDDSVRQTITQRIESFYFK 402

Human   460 DWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG----SPTYFYAFYHHCQSLMKPAWS- 519
            ...|.|  :...:.|..|.:|..:|  :.:...|..|..    :|||.|.|.|      |.|.|
  Fly   403 SGHDYD--KANHQNLTDLISDGWFV--AGIDEYLRLRMSQEDVAPTYVYLFDH------KGAASF 457

Human   520 ------------DAAHGDEVPYVFGVPMVGPTDLF----PCNFSKNDVMLSAVVMTYWTNFAKTG 568
                        .|.|.:|:.|:|.:    ..:||    |   ::.|:.|..:::..|.:|||||
  Fly   458 TEIFKGGRNEFYGACHAEELQYLFPI----GRELFVSAVP---TQKDLELRELMLHLWVSFAKTG 515

Human   569 DPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKP-------RVRDHYRATKVAFWKH 626
            :||   |.:..| |..       .||..:.....:..:|.|.       |:.:.....:|.||:.
  Fly   516 NPN---PTNVSF-HLP-------NWSPASSYPVEFARLGTKMEDSASIFRLENELMQHRVDFWRD 569

Human   627 LVPHLYNLH 635
            |.|||...|
  Fly   570 LQPHLPASH 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	175/646 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		1/24 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694
CG6414	NP_570089.1	COesterase	28..567	CDD:395084	175/646 (27%)