Protein Alignment NLGN3 and nlg-1

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_001257226.1
• Gene: nlg-1 / 181484
• WormBaseID: WBGene00006412
• Length: 847
• Species: Caenorhabditis elegans
• Alignment Length: 808
• Identity: 236/808 - (29%)
• Similarity: 365/808 - (45%)
• Gaps: 185/808 - (22%)

Human    43 TVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFP---- 103
            :|.|.:|.:||..|....:.|.||.||||:||...|.|:.||........|      ||.|
 Worm    22 SVTTSWGMVRGEVVSPEGDDLPPVAQYLGIPYGVAPTGQYRFNMAISAAKW------THMPKDAR 80

Human   104 ---PVCPQNIHTAVPEVMLPVWFTA-------NLDI---VATYIQEPNEDCLYLNVYVPTEDVKR 155
               |||   |.|.:||:.....|.|       ..|.   :..::::.:|||||:|:|||
 Worm    81 KVSPVC---IQTDMPELSETKRFRAFKHTSAQRFDFNHRLLPHLKKQSEDCLYMNIYVP------ 136

Human   156 ISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMID 220
                                              |..:|......||||.:||..|..||||..:
 Worm   137 ----------------------------------ERLEISRDNYLPVMVIVHGEEYGWGTGNAFN 167

Human   221 GSILASYGNVIVITLNYRVGVLGFLSTGDQAA-KGNYGLLDQIQALRWVSENIAFFGGDPRRITV 284
            |:.||:||::||:|||||:||.|||...:.:: .||.|:.|.:.||..::..:..||||.:.:|:
 Worm   168 GTTLAAYGHIIVVTLNYRLGVFGFLGRCESSSCSGNSGISDLVSALTMLNVILPSFGGDSKSVTL 232

Human   285 FGSGIGASCVSLL---TLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC------ 340
            .|.|.|||.||||   .|:.....||:|||:..|||||.||::..|.:|...||:::.|
 Worm   233 AGWGSGASLVSLLMASPLTQPGRRLFRRAILLDGSALSPWAISQNPQQYFMQLAEELACAPKNRT 297

Human   341 -NVLDTVD-MVDCLRQKSAKELVEQ--DIQPARYHVAFGPVIDGDVIPDDPEILM--EQGE-FLN 398
             :..|.|| :|.|::..|::.:.:.  .|....:...|.|::||.:||:.|::..  :.|. |..
 Worm   298 SSFNDNVDTIVRCMQVHSSENITKAVLKIDVPTFLSGFAPIVDGQLIPNKPQVSFSTQYGSLFRE 362

Human   399 YDIMLGVNQGEGLKFVEGVVDPED---GVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTD 460
            .|:::|::....    ..::..||   |:|.........:.|.|||.:  .::.:..:|...|||
 Worm   363 IDLLVGISSNPS----HHMISNEDLKVGISKEKRMRIFRSLVRNLYDF--HREEILASIINEYTD 421

Human   461 WAD-RDNPETRRKTLVALFTDHQWVEPSVVTADLHA----RYGSPTYFYAFYHHCQSLMKPAWSD 520
            |.: ||:|::.|..::...:|..:..|.:.|...|:    |..:.|:.:||.|..:|     ||.
 Worm   422 WENPRDHPKSIRNGVLNALSDVLYTAPLIETLRSHSADEVRKEANTFMFAFAHETRS-----WSQ 481

Human   521 ---------AAHGDEVPYVFGVPMV-GPTD--LFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKP 573
                     :..||.|||:||.|:. |.::  |: ..|:.:|..:|.|:|.|.:||.|:|||:||
 Worm   482 EQPNSGIRGSLSGDIVPYIFGYPLAQGDSEERLY-SGFNTDDKGISKVMMHYVSNFVKSGDPSKP 545

Human   574 VPQDTKFIHTKANRFEEVAWSKYN-PRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYN---- 633
            .|....|  ...:.|...||.::: |..:.||.|..:|||:::||..:|.||.:.:|.|:.
 Worm   546 NPMSKNF--PMGDVFHSTAWPQFDQPNREAYLEITDRPRVKNYYRNAQVGFWNNFIPQLHKNGKE 608

Human   634 ----------LHDMF----------HYTS-TTTKVPPPDTTHS--SHITRRPNGKTWSTKRPAIS 675
                      |.|.|          |::| .....|||....|  ..:|.:|        :|:.|
 Worm   609 TEPVGEEHHLLSDHFRKDSYFGKTRHFSSYANLPFPPPPMPPSPPPELTTKP--------KPSES 665

Human   676 P------AYSNENAQGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKD 734
            |      ..|.:.|.||:.|....|                .|.:|...|.:||....|:  |::
 Worm   666 PTTLQTTTESEKAAAGSFTGKALGG----------------VIFIGCGFLIMNVCLLIAV--RRE 712

Human   735 ---KRRQEPLRQPSPQ-----RGAGAPE 754
               |||.|...|...|     .|.||.:
 Worm   713 WGKKRRNEKKFQLQYQTYNSNHGGGAEQ 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	196/635 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		1/24 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694		14/56 (25%)
nlg-1	NP_001257226.1	COesterase	19..595	CDD:395084	196/635 (31%)