Protein Alignment NLGN3 and clt

DIOPT Version :10

• Sequence 1: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Sequence 2: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Alignment Length: 613
• Identity: 166/613 - (27%)
• Similarity: 242/613 - (39%)
• Gaps: 199/613 - (32%)

Human    46 THFGKLRGARVPLPSEILG----------PVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNAT 100
            |.|......:||:...:|.          ..:.:||||||.||:||.||..|.|
  Fly    12 TRFCSSMKVKVPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRP----------- 65

Human   101 HFPPVCPQNIHTAVPEVMLPVWFTANLDIV----ATYIQEP-------NEDCLYLNVYVPTEDVK 154
                              |..:....||..    .:|.::|       :||||:||||.|
  Fly    66 ------------------LERFQKQELDCSKEGNVSYQRDPFTLEVAGSEDCLFLNVYAP----- 107

Human   155 RISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNM- 218
              ..:..|.|                                   .||||:||||.:..|.||.
  Fly   108 --KVKSTRTP-----------------------------------LPVMVWIHGGGFFFGNGNSD 135

Human   219 --IDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRR 281
              ....::..  .|||:|||||:|.|||||..::...||.||.||..||.||.||||.|.|||..
  Fly   136 FHFPAKLMEQ--EVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNN 198

Human   282 ITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAV-NYQPVKYTSLLADKVGCNVL-- 343
            :|:||...|.|.|.|.|.:.|::.||.:||:|||:|...|.. |..|.| |..||:.:|....
  Fly   199 VTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAK-TRRLAELLGGGDFGG 262

Human   344 DTVDMVDCLRQKSAK---------ELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNY 399
            |:..::..|:.:.|.         :::..|.:......||.||::....||         .||..
  Fly   263 DSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPD---------RFLEQ 318

Human   400 DIM---------------LGVNQGEGLKFV--------------------EGVVDPEDGVSGTDF 429
            |||               :|.|..|||..|                    ..|:||:
  Fly   319 DIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDPQ-------- 375

Human   430 DYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWA-DRDNPETRRKTLVALFTDHQWVEPSVVTADL 493
                         .||.::...:...|.:...| .::|.:    .||.||:|:.:........::
  Fly   376 -------------APEAQEAASDIRAFFFNGQALSKENMD----NLVDLFSDYHFSMDLQRAVEI 423

Human   494 HA--RYGSPTYFYAF-YHHCQSLMKPAWSD-----AAHGDEVPYVFGVPMVG-PTDLFPCNFSKN 549
            ||  :..||.|||.. |...::|.|..:.:     .||.|::.|:|  .|.| .|::     :::
  Fly   424 HASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLF--QMAGDETEM-----NRD 481

Human   550 DVMLSAVVMTYWTNFAKTGDPN---KPV 574
            |:|::..:...|.|||:.|.|:   |||
  Fly   482 DLMVTERLCEMWANFARDGKPSPIWKPV 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NLGN3	NP_851820.1	COesterase	40..624	CDD:395084	166/613 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	164/603 (27%)