DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HAO1 and CG18003

DIOPT Version :9

Sequence 1:	NP_060015.1	Gene:	HAO1 / 54363	HGNCID:	4809	Length:	370	Species:	Homo sapiens
Sequence 2:	NP_001027401.1	Gene:	CG18003 / 3771779	FlyBaseID:	FBgn0061356	Length:	366	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	173/356 - (48%)
Similarity:	245/356 - (68%)	Gaps:	1/356 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     5 LICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQ 69
            |:|:.|:|:.|...|.|:..|||||||.::.||..|..||.|.:|.||.||:|:..|:||.:.|:
  Fly     3 LVCVEDFEKKAVGQLEKNALDYYRSGAGEQFTLGLNREAFRRLRLRPRCLRDVSRLDISTKIFGE 67

Human    70 RVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIY 134
            ::..|:.:..||||:|||.|||:...||....|:..:||:.:|:|:|::|...|:.::|.|||||
  Fly    68 QMQWPLGIAPTAMQKMAHPDGEVGNARAAGKAGSIFILSTLSTTSLEDLAAGAPDTIKWFQLYIY 132

Human   135 KDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENF 199
            |||.:|:||||:|||..:||:.:|:|.|..|:|..||||.|.||..|.:.||:....:.......
  Fly   133 KDRTITEKLVRRAEKANFKALVLTIDAPIFGHRRADVRNNFSLPSHLSLANFQGVKATGVGNAAM 197

Human   200 GDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQ 264
            | .||:..||:...||:|:|:||.||:.:|.||||.||:|..:||..|.:.|..|::||||||||
  Fly   198 G-ASGINEYVSSQFDPTITWKDIAWLKGITHLPIVVKGVLTAEDAVLAQEFGCAGLIVSNHGARQ 261

Human   265 LDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGV 329
            :|.|||:|:.|||||:||...:.|.||||:.:|.|:.||||||||.||||||.|||||:.|:|||
  Fly   262 IDTVPASIEALPEIVKAVGDNLVVMLDGGIMQGNDIFKALALGAKTVFVGRPAVWGLAYNGQKGV 326

Human   330 QDVLEILKEEFRLAMALSGCQNVKVIDKTLV 360
            :::|.:|:::|...|||.||||:..|...:|
  Fly   327 EEMLSVLRKDFETTMALIGCQNLGDITSAMV 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HAO1	NP_060015.1	FMN_dh	15..362	CDD:395850	169/346 (49%)
HAO1	NP_060015.1	Microbody targeting signal. /evidence=ECO:0000255	368..370
CG18003	NP_001027401.1	alpha_hydroxyacid_oxid_FMN	7..353	CDD:239203	169/346 (49%)
CG18003	NP_001027401.1	FMN_dh	17..359	CDD:279418	168/342 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140698
Domainoid	1	1.000	343	1.000	Domainoid score	I1065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6578
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2239
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54906
OrthoDB	1	1.010	-	-		D500918at33208
OrthoFinder	1	1.000	-	-		FOG0001123
OrthoInspector	1	1.000	-	-		oto88641
orthoMCL	1	0.900	-	-		OOG6_100930
Panther	1	1.100	-	-	LDO	PTHR10578
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1926
SonicParanoid	1	1.000	-	-		X693
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940