Protein Alignment GDAP1 and YGR201C

DIOPT Version :10

• Sequence 1: NP_061845.2
• Gene: GDAP1 / 54332
• HGNCID: 15968
• Length: 358
• Species: Homo sapiens
• Sequence 2: NP_011717.4
• Gene: YGR201C / 853115
• SGDID: S000003433
• Length: 225
• Species: Saccharomyces cerevisiae
• Alignment Length: 256
• Identity: 52/256 - (20%)
• Similarity: 84/256 - (32%)
• Gaps: 70/256 - (27%)

Human    40 VRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLI--HGENIICEATQIIDYLEQTFL 102
            :|.::....::..:.||.|......:..:.|.....:.|..:  |.|..:.||..|..||.....
Yeast    16 IRTIVPRGLVRSLKLDVKLADPSDAQQLYEREFPLRKYPTFVGPHDEWTLTEAMAIDYYLIHLSS 80

Human   103 DERTPRLMPDKESMYYPR--VQHYRELLDSLPMDAYTHGC-ILHPELTVDSMIPAYATTRIRSQI 164
            |:...|.:...|..:..|  :..:..|.:|   |.....| :..|.:.|    ..|..|..
Yeast    81 DKEAVRQLLGPEGDFKTRADILRWESLSNS---DFLNEVCEVFFPLIGV----KPYNATEF---- 134

Human   165 GNTESELKKLAEENPD-LQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQVETELQRRNE 228
                    |.|.||.| :...|   :||||.
Yeast   135 --------KAARENVDTIVSLY---EKRLKK---------------------------------- 154

Human   229 ETPEEGQQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGNGKRPNLETYYERVLKRKTF 289
                  ||..:|.:..||||: ::.....|.|:.|....| ..|.|.:..::.||:|.:.|
Yeast   155 ------QQYLVCDDHETLADL-ISAAAFSLGFISFFDETW-RSKHPEVTRWFNRVIKSRFF 207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	12/59 (20%)
		GST_C_GDAP1	179..289	CDD:198336	22/110 (20%)
		Required for mitochondrial localization	320..358
YGR201C	NP_011717.4	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	4..78	CDD:469754	13/61 (21%)
		GST_C_EF1Bgamma_like	98..220	CDD:198290	36/174 (21%)