DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDAP1 and GstD7

DIOPT Version :9

Sequence 1:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_525114.1	Gene:	GstD7 / 48340	FlyBaseID:	FBgn0010043	Length:	224	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	52/262 - (19%)
Similarity:	95/262 - (36%)	Gaps:	75/262 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    26 LILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICEA 90
            |.||::..:.:|:.:::|.....|:.....::....:..:|.|:|:|....:|.|:....:|.|:
  Fly     4 LDLYNFPMAPASRAIQMVAKALGLELNSKLINTMEGDQLKPEFVRINPQHTIPTLVDNGFVIWES 68

Human    91 TQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDS-LPMDAYTHGCILHPELTVDSMIPA 154
            ..|..||.:.:       ..||  |..||.....|.|::. |..|..|    |:..||      .
  Fly    69 RAIAVYLVEKY-------GKPD--SPLYPNDPQKRALINQRLYFDMGT----LYDALT------K 114

Human   155 YATTRIRS-QIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQ 218
            |.....|: :.|:.|:                                       ||::......
  Fly   115 YFFLIFRTGKFGDQEA---------------------------------------LDKVNSAFGF 140

Human   219 VETELQRRNEETPEEGQQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGNGKRPNLETYYERV 283
            :.|.|         |||. ::.|...|:||:.:..|:..:::..|     ...|.||:|.:.:..
  Fly   141 LNTFL---------EGQD-FVAGSQLTVADIVILATVSTVEWFSF-----DLSKFPNVERWLKNA 190

Human   284 LK 285
            .|
  Fly   191 PK 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	16/71 (23%)
		GST_C_GDAP1	179..289	CDD:198336	18/107 (17%)
		Required for mitochondrial localization	320..358
GstD7	NP_525114.1	GST_N_Delta_Epsilon	4..77	CDD:239343	17/72 (24%)
		GstA	6..188	CDD:223698	50/254 (20%)
		GST_C_Delta_Epsilon	92..206	CDD:198287	30/165 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930