DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDAP1 and GstD6

DIOPT Version :9

Sequence 1:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_524915.1	Gene:	GstD6 / 48339	FlyBaseID:	FBgn0010042	Length:	215	Species:	Drosophila melanogaster

Alignment Length:	263	Identity:	48/263 - (18%)
Similarity:	87/263 - (33%)	Gaps:	82/263 - (31%)

- Green bases have known domain annotations that are detailed below.

Human    28 LYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICEATQ 92
            ||:.:.|.|::.|.:......::.....|:..:.|..||||:::|....:|.|:....:|.|...
  Fly     3 LYNMSGSPSTRAVMMTAKAVGVEFNSIQVNTFVGEQLEPWFVKINPQHTIPTLVDNLFVIWETRA 67

Human    93 IIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPAYAT 157
            |:.||.:.:          .|:...||:                            |....|...
  Fly    68 IVVYLVEQY----------GKDDSLYPK----------------------------DPQKQALIN 94

Human   158 TRIRSQIGNTESELKK-----LAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLD 217
            .|:...:|.....:.|     |....|..||                 |::.|....|.|...||
  Fly    95 QRLYFDMGTLYDGIAKYFFPLLRTGKPGTQE-----------------NLEKLNAAFDLLNNFLD 142

Human   218 QVETELQRRNEETPEEGQQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGNGKRPNLETYYER 282
                             .|.::.|...::||:.:..|:...:.:.|..:     |.||::.:|:.
  Fly   143 -----------------GQDYVAGNQLSVADIVILATVSTTEMVDFDLK-----KFPNVDRWYKN 185

Human   283 VLK 285
            ..|
  Fly   186 AQK 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	18/69 (26%)
		GST_C_GDAP1	179..289	CDD:198336	20/107 (19%)
		Required for mitochondrial localization	320..358
GstD6	NP_524915.1	GST_N_Delta_Epsilon	1..74	CDD:239343	19/70 (27%)
		PLN02395	11..208	CDD:166036	45/255 (18%)
		GST_C_Delta_Epsilon	88..204	CDD:198287	25/140 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840