DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDAP1 and GstD4

DIOPT Version :9

Sequence 1:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_524913.1	Gene:	GstD4 / 48337	FlyBaseID:	FBgn0010040	Length:	215	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	53/270 - (19%)
Similarity:	96/270 - (35%)	Gaps:	78/270 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    29 YHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICEATQI 93
            |:...|..|:.:.:|.....|:..:..:.:...||.:|.|::||....:|.|:.....|.|:..|
  Fly     4 YYSPRSSGSRTIIMVAKALGLELNKKQLRITEGEHLKPEFLKLNPQHTIPTLVDNGFAIWESRAI 68

Human    94 IDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDS-LPMDAYTHGCILHPELTVDSMIPAYAT 157
            ..||.:.:          .|:...:|.....|.|::. |..|..|    ||     ||.:..|..
  Fly    69 AVYLVEKY----------GKDDSLFPNDPQKRALINQRLYFDMGT----LH-----DSFMKYYYP 114

Human   158 TRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQVETE 222
            .....|:||.|                                |.|.::...:.|:..|
  Fly   115 FIRTGQLGNAE--------------------------------NYKKVEAAFEFLDIFL------ 141

Human   223 LQRRNEETPEEGQQPWLCGESFTLADVSLAVTLHRLKFLGF-------ARRNWGNGKR--PNLET 278
                      |||. ::.|...|:||:::..::...:.:.|       ..|.:.|.|:  |..:.
  Fly   142 ----------EGQD-YVAGSQLTVADIAILSSVSTFEVVEFDISKYPNVARWYANAKKITPGWDE 195

Human   279 YYERVLKRKT 288
            .::.:|:.||
  Fly   196 NWKGLLQMKT 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	17/68 (25%)
		GST_C_GDAP1	179..289	CDD:198336	19/119 (16%)
		Required for mitochondrial localization	320..358
GstD4	NP_524913.1	PRK10542	1..184	CDD:182533	47/247 (19%)
		GST_N_Delta_Epsilon	1..74	CDD:239343	18/69 (26%)
		GST_C_Delta_Epsilon	88..204	CDD:198287	31/173 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840