DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDAP1 and GstD2

DIOPT Version :9

Sequence 1:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_524912.1	Gene:	GstD2 / 48335	FlyBaseID:	FBgn0010038	Length:	215	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	48/259 - (18%)
Similarity:	82/259 - (31%)	Gaps:	100/259 - (38%)

- Green bases have known domain annotations that are detailed below.

Human    42 LVIAEKALKCEEHDVSLPLSEHNE--PWFMRLNSTGEVPVLIHGENIICEATQIIDYL-----EQ 99
            :::..|||..|.:...|...|..:  |.|::||....:|.|:.....|.|:..|..||     :.
  Fly    15 VIMVAKALGLELNKKLLNTMEGEQLKPEFVKLNPQHTIPTLVDNGFSIWESRAIAVYLVEKYGKD 79

Human   100 TFLDERTP--------RLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPAYA 156
            .:|....|        ||..|..::|....::|                           .|.:.
  Fly    80 DYLLPNDPKKRAVINQRLYFDMGTLYESFAKYY---------------------------YPLFR 117

Human   157 TTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQVET 221
            |.:..|                                   |.|    ||:|    |.....::|
  Fly   118 TGKPGS-----------------------------------DED----LKRI----ETAFGFLDT 139

Human   222 ELQRRNEETPEEGQQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGNGKRPNLETYYERVLK 285
            .|         |||: ::.|:..|:||:::..|:..     |....:...|..|:..:|:...|
  Fly   140 FL---------EGQE-YVAGDQLTVADIAILSTVST-----FEVSEFDFSKYSNVSRWYDNAKK 188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	17/62 (27%)
		GST_C_GDAP1	179..289	CDD:198336	21/107 (20%)
		Required for mitochondrial localization	320..358
GstD2	NP_524912.1	GST_N_Delta_Epsilon	1..74	CDD:239343	17/58 (29%)
GstD2	NP_524912.1	GST_C_Delta_Epsilon	88..204	CDD:198287	29/186 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154503
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840