DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDAP1 and Gdap1

DIOPT Version :9

Sequence 1:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_647945.1	Gene:	Gdap1 / 38597	FlyBaseID:	FBgn0035587	Length:	327	Species:	Drosophila melanogaster

Alignment Length:	343	Identity:	99/343 - (28%)
Similarity:	162/343 - (47%)	Gaps:	25/343 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAERQEEQRGSPPLRAEGKA-DAEV-KLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEH 63
            |:|:.:|....||...:.|| |... |.:|:...::|.:|||.:|..||.:....:.|.|...|.
  Fly     1 MSEQTKEIEALPPTLQDFKAPDLPANKPVLFFHPYNFHAQKVLMVFYEKKIDFFPYVVDLCNGEQ 65

Human    64 NEPWFMRLNSTGEVPVLIHGENIICEATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELL 128
            ...||:.||..|:||||..|..:|..:|.||:|:|..|..:|:  |.|...|..:.::..:.:.:
  Fly    66 YSNWFLNLNPKGDVPVLQDGALVIPSSTHIINYVESKFRGDRS--LKPAHNSKEFDQMLIFEQAM 128

Human   129 DSLPMDAYTHGCILHPELTVDSMIPAYATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLK 193
            ..||:...:.|..:|.:|.:....|.....| :|.:.|.|..|..|.....:......|.|.:|.
  Fly   129 ARLPVGTLSLGSFIHDDLKLVPKAPFIGPVR-QSCLKNNEKVLDLLRHSVDEQATKKAALQHKLD 192

Human   194 SKLLDHDNVKYLKKILDELEKVLDQVETELQRRNEE-TPEEGQQPWLCGESFTLADVSLAVTLHR 257
            .:|..|:    |....:|.:||||.|...|....:| |.:..:..||.|:..::||:||.:.|||
  Fly   193 IQLRRHE----LASSREEFQKVLDAVRHFLLYVEQELTAQAPRVEWLTGDELSVADISLGLLLHR 253

Human   258 LKFLGFARRNWGNGKRPNLETYYERVLKRKTFNKVLGHVNNILISAVLPTAFRVAKKRAPKVLGT 322
            |..|||..:.|..||.|.:|.|:.|..:|::|::            :.|:.|.:.::...:..|.
  Fly   254 LYQLGFENQFWTFGKLPQVEAYFLRFRQRESFHR------------LQPSNFAILREMWTRTPGN 306

Human   323 TLVVGLLAGVGYFAFMLF 340
               ..|.||.|:....:|
  Fly   307 ---YKLGAGAGFLGMAMF 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	26/71 (37%)
		GST_C_GDAP1	179..289	CDD:198336	37/110 (34%)
		Required for mitochondrial localization	320..358		6/21 (29%)
Gdap1	NP_647945.1	GST_N_family	28..100	CDD:238319	26/71 (37%)
		GstA	30..290	CDD:223698	82/278 (29%)
		GST_C_family	178..285	CDD:295467	37/110 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I11013
eggNOG	1	0.900	-	-		E1_KOG4420
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40713
Inparanoid	1	1.050	126	1.000	Inparanoid score	I4703
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60156
OrthoDB	1	1.010	-	-		D1011771at2759
OrthoFinder	1	1.000	-	-		FOG0003318
OrthoInspector	1	1.000	-	-		otm42206
orthoMCL	1	0.900	-	-		OOG6_107250
Panther	1	1.100	-	-	LDO	PTHR44188
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5606
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870