Protein Alignment GDAP1 and GstE12

DIOPT Version :10

• Sequence 1: NP_061845.2
• Gene: GDAP1 / 54332
• HGNCID: 15968
• Length: 358
• Species: Homo sapiens
• Sequence 2: NP_611964.1
• Gene: GstE12 / 37960
• FlyBaseID: FBgn0027590
• Length: 223
• Species: Drosophila melanogaster
• Alignment Length: 285
• Identity: 63/285 - (22%)
• Similarity: 97/285 - (34%)
• Gaps: 99/285 - (34%)

Human    25 KLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICE 89
            |..||:.|.|..|:.|.|......|..|...::|...||..|.|::||....:|.||.||..|.:
  Fly     3 KPALYYATLSPPSRAVLLTAKAIGLDLELRPINLLKGEHLTPEFLKLNPQHTIPTLIDGEATIID 67

Human    90 ATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPA 154
            :..|..||.:.:         ..||...||     :||:....:||..|         :||   .
  Fly    68 SHAICAYLVEKY---------GQKEQQLYP-----KELVQRANVDARLH---------LDS---G 106

Human   155 YATTRIR------SQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELE 213
            :...|:|      ...|:|:..:.|:|                            |::|..:.||
  Fly   107 HLFARLRFLYEPILYYGSTDCSIDKIA----------------------------YIQKCWEILE 143

Human   214 KVLDQVETELQRRNEETPEEGQQPWLCGESFTLADVSLAVT---------LHRLKFLGFARRNWG 269
            ..|.                 .||:|||...|:||.....|         :...||
  Fly   144 GFLK-----------------DQPYLCGSDLTIADFCAVATVTSVNDTAPIDEFKF--------- 182

Human   270 NGKRPNLETYYERVLKRKTFNKVLG 294
                |.:..:.:|:.:...:.:|.|
  Fly   183 ----PKMHAWLKRLAELPYYQEVNG 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	24/71 (34%)
		GST_C_GDAP1	179..289	CDD:198336	18/118 (15%)
		Required for mitochondrial localization	320..358
GstE12	NP_611964.1	GST_N_Delta_Epsilon	4..77	CDD:239343	25/72 (35%)
		GST_C_Delta_Epsilon	92..210	CDD:198287	31/182 (17%)