DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDAP1 and GstE8

DIOPT Version :9

Sequence 1:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_001286571.1	Gene:	GstE8 / 37113	FlyBaseID:	FBgn0063492	Length:	222	Species:	Drosophila melanogaster

Alignment Length:	241	Identity:	49/241 - (20%)
Similarity:	80/241 - (33%)	Gaps:	79/241 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    25 KLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICE 89
            |||||....|...:..:|.:|...:..|...::....|...|.|:|.|....||.|....:.|.:
  Fly     3 KLILYGTEASPPVRAAKLTLAALGIPYEYVKINTLAKETLSPEFLRKNPQHTVPTLEDDGHFIWD 67

Human    90 ATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTH---GCILHPELTVDSM 151
            :..|..||...:          .:....||     ::||....:|...|   |.:.     |:.:
  Fly    68 SHAISAYLVSKY----------GQSDTLYP-----KDLLQRAVVDQRLHFESGVVF-----VNGL 112

Human   152 ----IPAYATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDEL 212
                .|.:||       |.|.                 |.|::                  .|.:
  Fly   113 RGITKPLFAT-------GQTT-----------------IPKER------------------YDAV 135

Human   213 EKVLDQVETELQRRNEETPEEGQQPWLCGESFTLADVSLAVTLHRL 258
            .::.|.|||.|...:          ::.|:..|:||.||..::..|
  Fly   136 IEIYDFVETFLTGHD----------FIAGDQLTIADFSLITSITAL 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	19/71 (27%)
		GST_C_GDAP1	179..289	CDD:198336	15/80 (19%)
		Required for mitochondrial localization	320..358
GstE8	NP_001286571.1	GstA	4..196	CDD:223698	48/240 (20%)
		GST_N_Delta_Epsilon	4..77	CDD:239343	20/72 (28%)
		GST_C_Delta_Epsilon	91..209	CDD:198287	25/138 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840