Protein Alignment GDAP1 and GstE7

DIOPT Version :10

• Sequence 1: NP_061845.2
• Gene: GDAP1 / 54332
• HGNCID: 15968
• Length: 358
• Species: Homo sapiens
• Sequence 2: NP_611329.1
• Gene: GstE7 / 37112
• FlyBaseID: FBgn0063493
• Length: 223
• Species: Drosophila melanogaster
• Alignment Length: 271
• Identity: 55/271 - (20%)
• Similarity: 95/271 - (35%)
• Gaps: 69/271 - (25%)

Human    25 KLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICE 89
            |||||....|...:.|:|.:|...:..|..:|:....|:....|::.|....||.|....:.|.:
  Fly     3 KLILYGLEASPPVRAVKLTLAALEVPYEFVEVNTRAKENFSEEFLKKNPQHTVPTLEDDGHYIWD 67

Human    90 ATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPA 154
            :..||.||...:          .|....||:....|.::|..          ||.|   ..:|.|
  Fly    68 SHAIIAYLVSKY----------GKTDSLYPKDLLQRAVVDQR----------LHFE---SGVIFA 109

Human   155 YATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQV 219
            .|...|...:                    :..||..:..:..|     .:.::.|.|||.|
  Fly   110 NALRSITKPL--------------------FAGKQTMIPKERYD-----AIIEVYDFLEKFL--- 146

Human   220 ETELQRRNEETPEEGQQPWLCGESFTLADVSLAVTLHRLKFLGFARRNWGNGKRPNLETYYERVL 284
                          ....::.|...|:||.|:..|:..|:.  |.:.:  ..|.|.:..:::|:.
  Fly   147 --------------AGNDYVAGNQLTIADFSIISTVSSLEV--FVKVD--TTKYPRIAAWFKRLQ 193

Human   285 KRKTFNKVLGH 295
            |...:.:..|:
  Fly   194 KLPYYEEANGN 204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	20/71 (28%)
		GST_C_GDAP1	179..289	CDD:198336	20/109 (18%)
		Required for mitochondrial localization	320..358
GstE7	NP_611329.1	GST_N_Delta_Epsilon	4..77	CDD:239343	21/72 (29%)
		GST_C_Delta_Epsilon	91..209	CDD:198287	30/173 (17%)