Protein Alignment GDAP1 and GstE5

DIOPT Version :10

• Sequence 1: NP_061845.2
• Gene: GDAP1 / 54332
• HGNCID: 15968
• Length: 358
• Species: Homo sapiens
• Sequence 2: NP_611327.1
• Gene: GstE5 / 37110
• FlyBaseID: FBgn0063495
• Length: 222
• Species: Drosophila melanogaster
• Alignment Length: 291
• Identity: 62/291 - (21%)
• Similarity: 94/291 - (32%)
• Gaps: 99/291 - (34%)

Human    24 VKLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIIC 88
            |||.||....|...:.|:|.:|...|..|..:|::...|.....:::.|....||.|....|.|.
  Fly     2 VKLTLYGVNPSPPVRAVKLTLAALQLPYEFVNVNISGQEQLSEEYLKKNPEHTVPTLEDDGNYIW 66

Human    89 EATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIP 153
            ::..||.||...:.|          ....|||....|.::|..          ||.|..|
  Fly    67 DSHAIIAYLVSKYAD----------SDALYPRDLLQRAVVDQR----------LHFETGV----- 106

Human   154 AYATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLDHDNVKYLKKILDELEKVLDQ 218
                                          .:....|.:...|..:...:..|:..|.:.::.|.
  Fly   107 ------------------------------VFANGIKAITKPLFFNGLNRIPKERYDAIVEIYDF 141

Human   219 VETELQRRNEETPEEGQQPWLCGESFTLADVSLA---------VTLHRLKF---LGFARRNWGNG 271
            |||.|...:          ::.|:..|:||.||.         |.:.|||:   :.:.||
  Fly   142 VETFLAGHD----------YIAGDQLTIADFSLISSITSLVAFVEIDRLKYPRIIEWVRR----- 191

Human   272 KRPNLE--TYYER-----------VLKRKTF 289
                ||  .|||.           :||...|
  Fly   192 ----LEKLPYYEEANAKGARELETILKSTNF 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	20/71 (28%)
		GST_C_GDAP1	179..289	CDD:198336	28/134 (21%)
		Required for mitochondrial localization	320..358
GstE5	NP_611327.1	GstA	4..210	CDD:440390	57/279 (20%)