DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDAP1 and GstE1

DIOPT Version :9

Sequence 1:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_611323.1	Gene:	GstE1 / 37106	FlyBaseID:	FBgn0034335	Length:	224	Species:	Drosophila melanogaster

Alignment Length:	232	Identity:	47/232 - (20%)
Similarity:	77/232 - (33%)	Gaps:	70/232 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    26 LILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICEA 90
            ::||....|...:.|:|.:....|..|..:|:|...||....:::.|....||:|......|.::
  Fly     6 IVLYGTDLSPCVRTVKLTLKVLNLDYEYKEVNLQAGEHLSEEYVKKNPQHTVPMLDDNGTFIWDS 70

Human    91 TQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYRELLDSLPMDAYTHGCILHPELTVDSMIPAY 155
            ..|..||...:.          |....||:....|              .|::..|..|:.:
  Fly    71 HAIAAYLVDKYA----------KSDELYPKDLAKR--------------AIVNQRLFFDASV--- 108

Human   156 ATTRIRSQIGNTESELKKLAEENPDLQEAYIAKQKRLKSKLLD--HDNVKYLKKILDELEKVLDQ 218
                |.:.|.|..             :..:|.....:..:.||  |..:|.|:..|
  Fly   109 ----IYASIANVS-------------RPFWINGVTEVPQEKLDAVHQGLKLLETFL--------- 147

Human   219 VETELQRRNEETPEEGQQPWLCGESFTLADVSLAVTL 255
                           |..|:|.|:|.||||:|...|:
  Fly   148 ---------------GNSPYLAGDSLTLADLSTGPTV 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	18/71 (25%)
		GST_C_GDAP1	179..289	CDD:198336	18/79 (23%)
		Required for mitochondrial localization	320..358
GstE1	NP_611323.1	GST_N_Delta_Epsilon	6..79	CDD:239343	19/72 (26%)
		GstA	8..197	CDD:223698	47/230 (20%)
		GST_C_Delta_Epsilon	94..210	CDD:198287	25/134 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154575
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930