DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GDAP1 and GstE10

DIOPT Version :9

Sequence 1:	NP_061845.2	Gene:	GDAP1 / 54332	HGNCID:	15968	Length:	358	Species:	Homo sapiens
Sequence 2:	NP_001286570.1	Gene:	GstE10 / 37105	FlyBaseID:	FBgn0063499	Length:	240	Species:	Drosophila melanogaster

Alignment Length:	243	Identity:	55/243 - (22%)
Similarity:	99/243 - (40%)	Gaps:	44/243 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    26 LILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNEPWFMRLNSTGEVPVLIHGENIICEA 90
            ||||....|...:.|.|.:....|..|.|.:.:...:|.:|..:|.|....||:|..||:.|.::
  Fly     4 LILYGTESSPPVRAVLLTLRALQLDHEFHTLDMQAGDHLKPDMLRKNPQHTVPMLEDGESCIWDS 68

Human    91 TQIIDYLEQTFL--DERTP-----RLMPDKESMY---------YPRVQH--YRELLDSLP----- 132
            ..||.||...:.  ||..|     |.:.|:...:         :.::|.  ::|....:|
  Fly    69 HAIIGYLVNKYAQSDELYPKDPLKRAVVDQRLHFETGVLFHGIFKQLQRALFKENATEVPKDRLA 133

Human   133 --MDAYT--------HGCILHPELTV-DSMIPAYATTRIRSQIGNTESELKKLAEENPDLQEAYI 186
              .|||.        :..:..|:||: |..|.|..:|...|......::..||:        |::
  Fly   134 ELKDAYALLEQFLAENPYVAGPQLTIADFSIVATVSTLHLSYCPVDATKYPKLS--------AWL 190

Human   187 AKQKRLKSKLLDHDNVKYLKKILDELEKVLDQVETELQRRNEETPEEG 234
            |:...|  ...:.||::..:.:.|::...|.:...:|.::..|..:.|
  Fly   191 ARISAL--PFYEEDNLRGARLLADKIRSKLPKQFDKLWQKAFEDIKSG 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	23/71 (32%)
		GST_C_GDAP1	179..289	CDD:198336	10/56 (18%)
		Required for mitochondrial localization	320..358
GstE10	NP_001286570.1	GstA	4..197	CDD:223698	48/202 (24%)
		GST_N_Delta_Epsilon	4..77	CDD:239343	24/72 (33%)
		GST_C_Delta_Epsilon	91..211	CDD:198287	23/129 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930