Protein Alignment GDAP1 and exc-4

DIOPT Version :10

• Sequence 1: NP_061845.2
• Gene: GDAP1 / 54332
• HGNCID: 15968
• Length: 358
• Species: Homo sapiens
• Sequence 2: NP_740950.2
• Gene: exc-4 / 173314
• WormBaseID: WBGene00001365
• Length: 290
• Species: Caenorhabditis elegans
• Alignment Length: 272
• Identity: 52/272 - (19%)
• Similarity: 106/272 - (38%)
• Gaps: 73/272 - (26%)

Human     1 MAERQEEQRGSPPLRAEGKADAEVKLILYHWTHSFSSQKVRLVIAEKALKCEEHDVSLPLSEHNE 65
            |||..:       :::.|...::..|.||.......::::     ...|.|:|
 Worm     1 MAEAYQ-------IQSNGDPQSKPLLELYVKASGIDARRI-----GADLFCQE------------ 41

Human    66 PWFMRLNSTGEVPVL---IHGENIICEATQIIDYLEQTFLDERTPRLMPDKESMYYPRVQHYREL 127
             ::|.|.:..|:.|.   :...|:..||      .::.||..:.|.::.:::.:.|   ...||:
 Worm    42 -FWMELYALYEIGVARVEVKTVNVNSEA------FKKNFLGAQPPIMIEEEKELTY---TDNREI 96

Human   128 LDSLPMDAYTHGCILHPELTVDSMIPAY-----ATTRIRSQIGNTESELKKLAEENPDLQEAYIA 187
                      .|.|.|  |..:..:|.:     |..||.:...|.:..|:...|.:...:|.  :
 Worm    97 ----------EGRIFH--LAKEFNVPLFEKDPSAEKRIENLYRNFKLFLRAKVEFDKGKKEP--S 147

Human   188 KQKRLKSKLLDHDNVKYLKKILDELEKVLDQVETELQRRNEETPEEGQQPWLCGESFTLADVSLA 252
            :.:.|.:::..|.|     ::.::|..: ||:.:|.:.|           :|.|.|.|..|..|.
 Worm   148 RVEDLPAQIKVHYN-----RVCEQLSNI-DQLLSERKSR-----------YLLGNSMTEYDCELM 195

Human   253 VTLHRLKFLGFA 264
            ..||.::.:|.:
 Worm   196 PRLHHIRIIGLS 207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GDAP1	NP_061845.2	GST_N_GDAP1	26..98	CDD:239350	13/74 (18%)
		GST_C_GDAP1	179..289	CDD:198336	18/86 (21%)
		Required for mitochondrial localization	320..358
exc-4	NP_740950.2	GST_N_CLIC	14..109	CDD:239359	23/133 (17%)
		GST_C_CLIC	115..248	CDD:198307	24/112 (21%)