DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment POLH and RAD30

DIOPT Version :10

Sequence 1:NP_006493.1 Gene:POLH / 5429 HGNCID:9181 Length:713 Species:Homo sapiens
Sequence 2:NP_010707.3 Gene:RAD30 / 852028 SGDID:S000002827 Length:632 Species:Saccharomyces cerevisiae


Alignment Length:645 Identity:146/645 - (22%)
Similarity:250/645 - (38%) Gaps:140/645 - (21%)


- Green bases have known domain annotations that are detailed below.


Human     9 VALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWADDAKKLCP 73
            :|.:||:.||.||||.:....:..|...||:.|     ||||||.||.:|::|.....:|.|.|.
Yeast    26 IAHIDMNAFFAQVEQMRCGLSKEDPVVCVQWNS-----IIAVSYAARKYGISRMDTIQEALKKCS 85

Human    74 DLL---------------------------LAQVRESRGKANLTKYREASVEVMEIM-SRFAVIE 110
            :|:                           ..|:.....|.:|..||..|.:.::|. |...::|
Yeast    86 NLIPIHTAVFKKGEDFWQYHDGCGSWVQDPAKQISVEDHKVSLEPYRRESRKALKIFKSACDLVE 150

Human   111 RASIDEAYVDLTSAVQERLQKLQGQPISADL--------LPSTYIEG-------LPQGPTTAEET 160
            ||||||.::||.......|.......::.||        :...:|.|       ||..|... ::
Yeast   151 RASIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGGNYDINSHLPLIPEKI-KS 214

Human   161 VQKEG--MRKQG---LFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCSAGISHNK 220
            ::.||  ...:|   :..|           .|:.|.:|:.:.:.:|.:|:...|:..|.|:|..|
Yeast   215 LKFEGDVFNPEGRDLITDW-----------DDVILALGSQVCKGIRDSIKDILGYTTSCGLSSTK 268

Human   221 VLAKLACGLNKPNRQTLVSHGSVPQLF--SQMPIRKIRSLGGKLGASVIEILGIEY--------- 274
            .:.|||....||:.||:|.:..:....  .:..|....:|||.||..:|::|.:.:         
Yeast   269 NVCKLASNYKKPDAQTIVKNDCLLDFLDCGKFEITSFWTLGGVLGKELIDVLDLPHENSIKHIRE 333

Human   275 -----MGELTQFTESQL-QSHFGEKNGS-----------WLYAMCRGIEHDPVKPRQLPKTIGCS 322
                 .|:|.:|.:::: ||.:.....:           .|:.:.||....|:..|.:.|::..:
Yeast   334 TWPDNAGQLKEFLDAKVKQSDYDRSTSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSN 398

Human   323 KNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCAL 387
            ||..||:..:..:.:. ||.....||..|:.....:.:::.....|||.:: .|.....|:...:
Yeast   399 KNLRGKSCNSIVDCIS-WLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLK-TKSYEVYRKSGPV 461

Human   388 TRYDAHKMSHDAFTV---------IKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSF 443
            .....:..||:...|         ||..|.|..      |||.|.:..|.|              
Yeast   462 AYKGINFQSHELLKVGIKFVTDLDIKGKNKSYY------PLTKLSMTITNF-------------- 506

Human   444 LSSDPSSLPK--VPVTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEASLSSLTAPTQ 506
               |...|.|  |.:..::..|..|.......:|.|:|      ||.|:....|.....:|...|
Yeast   507 ---DIIDLQKTVVDMFGNQVHTFKSSAGKEDEEKTTSS------KADEKTPKLECCKYQVTFTDQ 562

Human   507 APMSNSPS-----KPSLPFQTSQSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNPWSNCK 561
            ..:.....     |.|.....::.:.....|.:|.||..:|:.|:...::||:...::.|
Yeast   563 KALQEHADYHLALKLSEGLNGAEESSKNLSFGEKRLLFSRKRPNSQHTATPQKKQVTSSK 622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POLHNP_006493.1 PolY_Pol_eta 10..428 CDD:176456 118/502 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..472 6/32 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 495..527 5/36 (14%)
zf_UBZ 631..661 CDD:465769
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 677..705
PIP-box. /evidence=ECO:0000269|PubMed:15149598, ECO:0000269|PubMed:16357261 701..708
RAD30NP_010707.3 PolY_Pol_eta 27..505 CDD:176456 118/502 (24%)
Blue background indicates that the domain is not in the aligned region.

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