Protein Alignment POLH and Polh

DIOPT Version :10

• Sequence 1: NP_006493.1
• Gene: POLH / 5429
• HGNCID: 9181
• Length: 713
• Species: Homo sapiens
• Sequence 2: NP_109640.1
• Gene: Polh / 80905
• MGIID: 1891457
• Length: 694
• Species: Mus musculus
• Alignment Length: 720
• Identity: 566/720 - (78%)
• Similarity: 611/720 - (84%)
• Gaps: 33/720 - (4%)

Human     1 MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWA 65
            ||.||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||
Mouse     1 MAPGQNRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRNMWA 65

Human    66 DDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQ 130
            |||||||||||||||||||||||||||||||||||||||.|||||||||||||:|||||||||||
Mouse    66 DDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSYFAVIERASIDEAYIDLTSAVQERLQ 130

Human   131 KLQGQPISADLLPSTYIEGLPQGPTTAEETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAV 195
            |||||||||||||||||||||:|| |.|||||||.:|||||.|||||||.|:.|||||:|||||:
Mouse   131 KLQGQPISADLLPSTYIEGLPRGP-TVEETVQKEAIRKQGLLQWLDSLQSDDPTSPDLRLTVGAM 194

Human   196 IVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGG 260
            ||||||||||.:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   195 IVEEMRAAIESKTGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGG 259

Human   261 KLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNF 325
            ||||||||:|||||||:||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   260 KLGASVIEVLGIEYMGDLTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSKNF 324

Human   326 PGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRY 390
            ||||||||||||||||||||.|||||||||||||||||||||||||.|||:|||||||||||.||
Mouse   325 PGKTALATREQVQWWLLQLALELEERLTKDRNDNDRVATQLVVSIRFQGDRRLSSLRRCCALPRY 389

Human   391 DAHKMSHDAFTVIKNCNTSGIQTEWSPPLTMLFLCATKFSASAPSSSTDITSFLSSDPSSLPKVP 455
            ||||||.|||..|:|||||||||||||||||||||||||||:||.:.||||:|||||.|..||||
Mouse   390 DAHKMSQDAFAAIRNCNTSGIQTEWSPPLTMLFLCATKFSAAAPPACTDITAFLSSDSSCQPKVP 454

Human   456 VTSSEAKTQGSGPAVTATKKATTSLESFFQKAAERQKVKEASLSSLTAPTQAPMSNSPSKPSLPF 520
            :.|||.:||||||||..:|:|.|||.|||||||::|::||.|...|...|:    ...|||||.|
Mouse   455 IASSETRTQGSGPAVPTSKEAATSLASFFQKAAKKQRMKETSFVPLNTATE----KLSSKPSLVF 515

Human   521 QTSQSTGTEPFFKQKSLLLKQKQLNNSSVSSPQQNPWSNCKALPNSLPTEYPGCVPV-C------ 578
            |:||:||::.|||||||||:..||:||:...|           |.:.|...|.|:|. |
Mouse   516 QSSQTTGSQSFFKQKSLLLQHTQLSNSAAPDP-----------PQASPAAQPSCLPAECVDSGPD 569

Human   579 EGVSKLEESSKATPAEMDLAHNSQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVP 643
            :|..| ..||||...||::|.:|.::..|.|..| .||||:||        ||||.||||.||||
Mouse   570 DGAVK-PVSSKAVSTEMNVAGDSPNVLDSPAYNS-QEVTQRAT--------EDQVLCEKCDSLVP 624

Human   644 VWDMPEHMDYHFALELQKSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPRPEGMQTLESFF 708
            |||||||.|||||||||||||||.:|.||.:.|||.|||||||||.|.::||.||.|||||||||
Mouse   625 VWDMPEHTDYHFALELQKSFLQPCTSKPQAIPAVSPQGKRNPKSPSASSSKRLRPHGMQTLESFF 689

Human   709 KPLTH 713
            |||||
Mouse   690 KPLTH 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLH	NP_006493.1	PolY_Pol_eta	10..428	CDD:176456	391/417 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..472		22/30 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..527		13/31 (42%)
		zf_UBZ	631..661	CDD:465769	26/29 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..705		20/27 (74%)
		PIP-box. /evidence=ECO:0000269|PubMed:15149598, ECO:0000269|PubMed:16357261	701..708		6/6 (100%)
Polh	NP_109640.1	PolY_Pol_eta	10..427	CDD:176456	391/417 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	565..598		10/33 (30%)
		zf_UBZ	612..642	CDD:465769	26/29 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	651..694		31/42 (74%)
		PIP-box. /evidence=ECO:0000250|UniProtKB:Q9Y253	682..689		6/6 (100%)