Protein Alignment POLH and polh

DIOPT Version :10

• Sequence 1: NP_006493.1
• Gene: POLH / 5429
• HGNCID: 9181
• Length: 713
• Species: Homo sapiens
• Sequence 2: NP_001035337.2
• Gene: polh / 678520
• ZFINID: ZDB-GENE-060421-4949
• Length: 749
• Species: Danio rerio
• Alignment Length: 777
• Identity: 381/777 - (49%)
• Similarity: 483/777 - (62%)
• Gaps: 98/777 - (12%)

Human     1 MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVSYEARAFGVTRSMWA 65
            |..|::|||||||||||:||||||..|.|:||||.|.|||:|||||||||||||||.||.|:|:|
Zfish     1 MDFGKERVVALVDMDCFYVQVEQRLKPELKNKPCVVAQYKTWKGGGIIAVSYEARAHGVGRNMFA 65

Human    66 DDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRFAVIERASIDEAYVDLTSAVQERLQ 130
            |||:||||||.:|:|.|:.|||:||.||||||||:|:||||||||||||||||:|||::|||||:
Zfish    66 DDARKLCPDLQVARVPEAHGKADLTHYREASVEVIEVMSRFAVIERASIDEAYMDLTASVQERLK 130

Human   131 KLQGQPISADLLPSTYIEGLPQGPTTAEET-VQKEGMRKQGLFQWLDSLQIDNLTSP-DLQLTVG 193
            ....|.|:|..|.:|:|:|.   ||..|.| :.::..|..||.||||.|.....:|| ||:|.||
Zfish   131 NTSVQDITAQQLKNTHIQGF---PTQQENTHLDRDAQRAAGLQQWLDLLSSSTESSPADLRLAVG 192

Human   194 AVIVEEMRAAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSL 258
            |:|||:||||:|..|||:|||||||||||||||||||||||||::...|||||||.:||.|||:|
Zfish   193 ALIVEQMRAAVEEHTGFRCSAGISHNKVLAKLACGLNKPNRQTVLPLSSVPQLFSTLPISKIRNL 257

Human   259 GGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPRQLPKTIGCSK 323
            |||||:|:.|.|.:|.||:||:|:.:||:.|||:|.|.|||.:|||||.:|||||||||:|||||
Zfish   258 GGKLGSSITETLSVENMGDLTRFSRAQLEQHFGDKTGPWLYDLCRGIEFEPVKPRQLPKSIGCSK 322

Human   324 NFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALT 388
            ||.|||.|.|::|||:||.|||.||||||.|||:.|.|||.||.|.:|..|.:|..|..|||||.
Zfish   323 NFAGKTCLRTKQQVQYWLHQLALELEERLNKDRDVNGRVARQLTVGVRQAGGQRSGSFSRCCALV 387

Human   389 RYDAHKMSHDAFTVIKNCNTSGIQTE-WSPPLTMLFLCATKFSASAPSSSTDITSFLSSDPSSLP 452
            ||||.||::|:.|:||:.||:|...| |||.||:|.|.|:|||.:..|||..||.|||||.:|.|
Zfish   388 RYDAMKMTNDSLTIIKSLNTAGAHQEAWSPALTLLHLSASKFSDAPSSSSAGITGFLSSDAASSP 452

Human   453 KVPVTSSEAKTQGSGPAVTATKKA-------TTSLESFFQ-KAAERQKVKEASLSSLTAPTQAPM 509
            .  .:||..::....||....::.       |||:.:||| |:.|:|:::    :||....|:
Zfish   453 S--QSSSSQRSPMERPAQKRKRQQDQRQRENTTSISAFFQRKSLEKQEIQ----NSLCPGDQS-- 509

Human   510 SNSPSKPSLPFQTSQSTGTEPFFKQKSLLLKQKQLN------NSSVSSPQQNPWSNCKALPNSLP 568
            :::..:.:.....:|.|.....|.|:..|.||:..|      :.||.:|::|   .|:..|..:.
Zfish   510 TSASGEHACGDTAAQKTTAISTFLQRESLEKQEIQNVSLDDEDQSVCAPEEN---TCREKPAGIS 571

Human   569 TEY-----------------------PGCVPVCE--------GVS------KLE----ESSKAT- 591
            |..                       ||..|..|        |:|      .||    ::|..|
Zfish   572 TSLQMKSLEKHQIQNSLCVGDQSVRAPGENPPREQTSDESPAGISSFFQMKSLEKHRIQNSPCTG 636

Human   592 ------PAEMDLAHNSQSMHASSASKSVLEVTQKATPNPSLLAAEDQVPCEKCGSLVPVWDMPEH 650
                  |||......:.....|..|....:....|.......|.||...||:||..|.||:.|||
Zfish   637 DPNIRAPAENTSRDQTSERSTSGMSGCFQQAVAPAGERVCSPAEEDLQVCERCGMKVLVWEFPEH 701

Human   651 MDYHFALELQKSFLQPHSSNPQVVSAVSHQGKRNPKSPLACTNKRPR---PEGMQTLESFFK 709
            .||||||:|||||   .|.:|..:           |:|.....||.|   |.|  ||.||||
Zfish   702 ADYHFALDLQKSF---SSGSPSQM-----------KTPSGSQAKRARVQEPRG--TLHSFFK 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLH	NP_006493.1	PolY_Pol_eta	10..428	CDD:176456	275/420 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..472		12/30 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	495..527		4/31 (13%)
		zf_UBZ	631..661	CDD:465769	18/29 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	677..705		8/30 (27%)
		PIP-box. /evidence=ECO:0000269|PubMed:15149598, ECO:0000269|PubMed:16357261	701..708		3/6 (50%)
polh	NP_001035337.2	PolY_Pol_eta	10..428	CDD:176456	275/420 (65%)
		zf_UBZ	682..712	CDD:465769	18/29 (62%)